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Antimalarial Drug II

Current Antimalarial and New Drug Developments

  • Wallace Peters
  • William H. G. Richards

Part of the Handbook of Experimental Pharmacology book series (HEP, volume 68 / 2)

Table of contents

  1. Front Matter
    Pages I-XVIII
  2. Antimalarial Drugs in Current Use

    1. Front Matter
      Pages 1-1
    2. E. W. McChesney, C. D. Fitch
      Pages 3-60
    3. W. Hofheinz, B. Merkli
      Pages 61-81
    4. P. E. Carson
      Pages 83-121
    5. H. J. Scholer, R. Leimer, R. Richle
      Pages 123-206
    6. R. Ferone
      Pages 207-221
  3. Novel Methods of Drug Development

    1. Front Matter
      Pages 223-223
    2. W. Peters
      Pages 225-236
    3. D. F. Worth, L. M. Werbel
      Pages 237-252
    4. A. Trouet, P. Pirson, R. Baurain, M. Masquelier
      Pages 253-264
  4. Recent Developments in Antimalarials

    1. Front Matter
      Pages 265-265
    2. T. R. Sweeney
      Pages 267-324
    3. T. R. Sweeney
      Pages 325-342
    4. T. R. Sweeney, R. O. Pick
      Pages 363-385
    5. K. H. Rieckmann
      Pages 443-470
    6. D. Warburton
      Pages 471-495
  5. Prevention of Drug Resistance

    1. Front Matter
      Pages 497-497
    2. W. Peters
      Pages 499-509
  6. Back Matter
    Pages 511-522

About this book

Introduction

The construction of this volume has been guided by two personal convictions. Experience in the field of experimental chemotherapy, both in the pharmaceutical industry and academia, has convinced us that recent quantum technological advances in biochemistry, molecular biology, and immunology will permit and, indeed, necessitate an increasingly greater use of rational drug development in the future than has been the custom up to now. In Part l, therefore, we asked our contributors to provide detailed reviews covering the biology of the malaria parasites and their relation with their hosts, the experimental procedures including culture techniques that are necessary to take a drug from primary screening to clinical trial, and an account of antimalarial drug resistance. Our second conviction is that many research workers are all too loath to learn from the lessons of the past. For this reason we asked the contributors to Part 2 of this volume to review very thoroughly the widely scattered but voluminous literature on those few chemical groups that have provided the antimalarial drugs in clinical use at the present time. Much can be learned from the history of their development and the problems that have arisen with them in man. Some indeed may still have much to offer if they can be deployed in better ways than they are at present. This question has been taken up by several authors.

Keywords

Drugs biochemistry biology chemistry chemotherapy clinical trial drug drug development drug resistance immunology malaria molecular biology parasite research resistance

Editors and affiliations

  • Wallace Peters
    • 1
  • William H. G. Richards
    • 2
  1. 1.London School of Hygiene and Tropical MedicineLondonGreat Britain
  2. 2.Wellcome Research LaboratoriesBerkhamsted, Herts.Great Britain

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-69254-3
  • Copyright Information Springer-Verlag Berlin Heidelberg 1984
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-69256-7
  • Online ISBN 978-3-642-69254-3
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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