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Triazines, Quinazolines and Related Dihydrofolate Reductase Inhibitors

  • Chapter
Antimalarial Drug II

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 68 / 2))

Abstract

The level of basic information on the biochemistry of the malarial parasite has been severely limited until recently, and the mode of action of even the classic drugs remains unclear. However, substantial knowledge has been collected on the parasite folic acid cycle (see Part I, Chap. 2) and on those structures which exert their antimalarial effects via its inhibition. Thus the sulphonamides and the so-called antifolates act on the synthesis of folate cofactors by the enzymes of the parasite (see Chap. 5). We will deal in this chapter with the recent developments among the antifolates and, in particular, with those whose role involves the inhibition of plasmodial dihydrofolate reductase.

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Authors
  1. P. Mamalis
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  2. L. M. Werbel
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Editors and Affiliations

  1. London School of Hygiene and Tropical Medicine, Keppel Street, London, WC1E 7HT, Great Britain

    Wallace Peters M.D., DSc, FRCP, DTM & H (Professor of Medical Protozoology) (Professor of Medical Protozoology)

  2. Wellcome Research Laboratories, Ravens Lane, Berkhamsted, Herts., HP4 2DY, Great Britain

    William H. G. Richards BSc, Ph. D. (Manager, Scientific Advisory Services) (Manager, Scientific Advisory Services)

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Mamalis, P., Werbel, L.M. (1984). Triazines, Quinazolines and Related Dihydrofolate Reductase Inhibitors. In: Peters, W., Richards, W.H.G. (eds) Antimalarial Drug II. Handbook of Experimental Pharmacology, vol 68 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69254-3_13

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  • DOI: https://doi.org/10.1007/978-3-642-69254-3_13

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