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A Dog Model to Evaluate Post-Cardiac Arrest Neurological Outcome

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Brain Protection

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Abstract

The success rate of cardiopulmonary resuscitation (CPR) in circulatory arrest (CA) even when performed by the most experienced emergency medicine groups is still less than 15%. The limit to final outcome is not the restoration of spontaneous circulation (ROSC) itself, but the events occurring following reperfusion of the brain by acid and toxic blood during CPR. The aim was to develop a dog model of ischemia in order to study the potential of physiological and pharmacological methods for restoring normal brain function after prolonged circulatory arrest.

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References

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Author information

Authors and Affiliations

  1. Critical Care Medicine Department, St. Jan Hospital, Brugges, Belgium

    A. Mullie & K. Vandevelde

  2. Department of Biochemistry, Janssen Pharmaceutica, 2340, Beerse, Belgium

    H. van Belle, J. van Loon, C. Hermans & A. Wauquir

  3. Department of Neuropharmacology, Janssen Pharmaceutica, 2340, Beerse, Belgium

    J. van Loon, C. Hermans & A. Wauquir

Authors
  1. A. Mullie
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  2. K. Vandevelde
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  3. H. van Belle
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  4. A. Jagenau
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  5. J. van Loon
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  6. C. Hermans
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  7. A. Wauquir
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Editor information

Editors and Affiliations

  1. Abteilung für Anaesthesiologie im Zentrum Chirurgie, Universität Heidelberg, Im Neuenheimer Feld 110, 6900, Heidelberg 1, Germany

    Klaus Wiedemann

  2. Institut für Pathochemie und Allgemeine Neurochemie im Zentrum Pathologie, Universität Heidelberg, Im Neuenheimer Feld 220-221, 6900, Heidelberg 1, Germany

    Siegfried Hoyer

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© 1983 Springer-Verlag Berlin Heidelberg

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Mullie, A. et al. (1983). A Dog Model to Evaluate Post-Cardiac Arrest Neurological Outcome. In: Wiedemann, K., Hoyer, S. (eds) Brain Protection. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69175-1_9

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  • DOI: https://doi.org/10.1007/978-3-642-69175-1_9

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69177-5

  • Online ISBN: 978-3-642-69175-1

  • eBook Packages: Springer Book Archive

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