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Pharmacological Effects in Protective and Resuscitative Models of Brain Hypoxia

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Brain Protection

Abstract

The first candidate compounds for pharmacological protection of the brain were barbiturates, but interest began to wane after these compounds were shown to be less effective in models of global brain ischemia followed by reperfusion (14). The search is now on for better protective agents. Obviously, both simple tests of brain protection and complicated tests of brain resuscitation are required at different stages of this process. The present article discusses the usefulness and predictability of brain protection experiments giving examples from our work with etomidate and flunarizine. These results are then discussed in the light of what is known about these compounds in resuscitation experiments.

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Author information

Authors and Affiliations

  1. Department of Neuropharmacology Janssen Pharmaceutica, 2340, Beerse, Belgium

    A. Wauquier, D. Ashton, C. Hermans & G. Clinke

Authors
  1. A. Wauquier
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  2. D. Ashton
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  3. C. Hermans
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  4. G. Clinke
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Editors and Affiliations

  1. Abteilung für Anaesthesiologie im Zentrum Chirurgie, Universität Heidelberg, Im Neuenheimer Feld 110, 6900, Heidelberg 1, Germany

    Klaus Wiedemann

  2. Institut für Pathochemie und Allgemeine Neurochemie im Zentrum Pathologie, Universität Heidelberg, Im Neuenheimer Feld 220-221, 6900, Heidelberg 1, Germany

    Siegfried Hoyer

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© 1983 Springer-Verlag Berlin Heidelberg

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Wauquier, A., Ashton, D., Hermans, C., Clinke, G. (1983). Pharmacological Effects in Protective and Resuscitative Models of Brain Hypoxia. In: Wiedemann, K., Hoyer, S. (eds) Brain Protection. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-69175-1_13

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  • DOI: https://doi.org/10.1007/978-3-642-69175-1_13

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-69177-5

  • Online ISBN: 978-3-642-69175-1

  • eBook Packages: Springer Book Archive

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