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Mefloquine

  • Chapter
Modes and Mechanisms of Microbial Growth Inhibitors

Part of the book series: Antibiotics ((ANTIBIOTICS,volume 6))

Abstract

Mefloquine (Fig. 1) is a quinolinemethanol blood schizontocide which is highly effective against drug-resistant as well as drug-sensitive P. falciparum and P. vivax, has a high therapeutic index, and has been accepted for clinical use. The mode and mechanism of mefloquine action are unknown, but available information suggests that cell membranes, internal as well as external, may be selective targets. A general review of mefloquine has recently been written by Sweeney (1981), and the development of mefloquine has been recounted by Schmidt et al. (1978a), and by Canfield and Rozman (1974), all of whom have been instrumental in this process.

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Authors
  1. A. D. Wolfe
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Editors and Affiliations

  1. Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, 20307, Washington, D.C., USA

    Fred E. Hahn Ph.D.

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© 1983 Springer-Verlag Berlin · Heidelberg

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Wolfe, A.D. (1983). Mefloquine. In: Hahn, F.E. (eds) Modes and Mechanisms of Microbial Growth Inhibitors. Antibiotics, vol 6. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68946-8_7

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  • DOI: https://doi.org/10.1007/978-3-642-68946-8_7

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68948-2

  • Online ISBN: 978-3-642-68946-8

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