Modes and Mechanisms of Microbial Growth Inhibitors

1. Front Matter

   Pages I-X

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2. Alafosfalin (Ro 03-7008, Alaphosphin)

   • C. H. Hassall

   Pages 1-11

3. Arabinosylcytosine

   • W. A. Creasey

   Pages 12-33

4. Chloramphenicol

   • F. E. Hahn

   Pages 34-45

5. Emetine, Cryptopleurine, Tylocrebrine and Other Functionally Related Alkaloids

   • R. S. Gupta

   Pages 46-70

6. Kirromycin and Related Antibiotics

   • H. Wolf, E. Fischer

   Pages 71-89

7. Anti-β-Lactamase Agents

   • J. R. Knowles

   Pages 90-107

8. Mefloquine

   • A. D. Wolfe

   Pages 108-120

9. Metronidazole

   • D. I. Edwards

   Pages 121-135

10. Neothramycin

    • N. Tanaka

    Pages 136-152

11. Pyrazofurin

    • E. Cadman

    Pages 153-160

12. Ribavirin

    • P. G. Canonico

    Pages 161-186

13. Rubradirin

    • F. Reusser

    Pages 187-198

14. Silver Sulfadiazine

    • M. S. Wysor

    Pages 199-232

15. Sporamycin

    • K. Komiyama, I. Umezawa

    Pages 233-237

16. Streptothricin F

    • J. Jonák, I. Rychlík

    Pages 238-247

17. Novel Inhibitors of Translation in Eukaryotic Systems

    • A. Jiménez, D. Vázquez

    Pages 248-254

18. Tunicamycin and Related Antibiotics

    • J. S. Tkacz

    Pages 255-278

19. Viral Translation Inhibitors

    • L. Carrasco, D. Vázquez

    Pages 279-295

20. Properties of Virginiamycin-like Antibiotics (Synergimycins), Inhibitors Containing Synergistic Components

    • C. Cocito

    Pages 296-332

It is not certain that the editors of Antibiotics I (1967), Drs. GOTTLffiB and SHAW, fully realized that they were laying the foundation for an entire series of which we present here Vol. VI. For some time to come, this will be the last volume of the Antibiotics series. There are several reasons for this. Firstly, the discovery of medicinally useful antibiotics has leveled off, because the number of microbiological products with antimicrobial properties is not infinite. In 1972 some 2500 antibiotic substances were known, of which approximately one per cent are clinically useful. Further search for antibiotics has led to increasing frequency of rediscoveries and drasti­ cally decreasing frequency of discoveries of new antibiotics. As the search for antibiotics with a standard methodology in conventional ecological niches has exhausted itself, there is a paucity of new and interesting substances on which to undertake modes/mechanisms of action studies. Secondly, the mechanism of action field has come of age and its results are now academic knowledge. This also holds true for synthetic chemothera­ peutic drugs and becomes the case rapidly for toxic substances with anti-eukar­ yotic action. The study of mechanisms of action was undertaken for two reasons: one was the basic scientific desire to know how antimicrobial substances inter­ fered with microbial biochemistry; the second one was the hope that such infor­ mation would be useful in the premeditated design of synthetic antimicrobials.

• Wachstumshemmung
• antimicrobials
• biochemistry
• biological
• chemistry
• growth

• Division of Communicable Diseases and Immunology, Walter Reed Army Institute of Research, USA

  Fred E. Hahn

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