Abstract
Both the cause of the breakdown of the oligodendrocyte-myelin unit in multiple sclerosis lesions and the reasons for the failure of repair by remyelination are unknown. In many experimental demyelinating conditions of the central nervous system substantial remyelination by oligodendrocytes is observed, in others Schwann cells may provide myelin of the peripheral type within central neural tissues. The precise environmental requirements for the production of myelin by oligodendrocytes have not been defined. Studies utilizing separated (and recombined) populations of Schwann cells, sensory neurons, and fibroblasts in tissue culture indicate that: 1) axonal contact provides a mitogenic signal for Schwann cells, 2) axonal contact engenders Schwann cell production of certain collagenous products, 3) secretory activity by Schwann cells appears to be necessary for the expression of Schwann cell function, and 4) long-term cultures containing only neurons and Schwann cells in serum-containing medium will not myelinate unless embryo extract is added in the culture medium or a population of fibroblasts is present in the culture dish. These observations on Schwann cells suggest that the expression of oligodendrocyte function may also have complex, as yet undefined, microenvironmental requirements.
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© 1982 Dr. S. Bernhard, Dahlem Konferenzen, Berlin
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Bunge, R.P. (1982). Cellular and Non-Cellular Influences on Myelin-Forming Cells. In: Sears, T.A. (eds) Neuronal-glial Cell Interrelationships. Dahlem Workshop Reports Life Sciences Research Report, vol 20. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68466-1_10
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DOI: https://doi.org/10.1007/978-3-642-68466-1_10
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