Neuronal-glial Cell Interrelationships

1. Front Matter

   Pages i-x

   PDF

2. Stephen W. Kuffler (1913–1980)

   1. Stephen W. Kuffler (1913–1980)

      • T. A. Sears

      Pages 1-4

3. Introduction

   1. Introduction

      • T. A. Sears

      Pages 5-10

4. Clinical Problems of Multiple Sclerosis

   1. Clinical Problems of Multiple Sclerosis

      • W. I. McDonald

      Pages 11-24

5. Ontogeny

   1. The Role of Neuronal-Glial Cell Interaction During Brain Development

      • P. Rakic

      Pages 25-38

   2. Membrane Specializations in Neuroglial Cells and at Neuron-Glia Contacts

      • E. Mugnaini

      Pages 39-56

   3. Developmental Disorders of Myelination in Mouse Mutants

      • A. J. Aguayo, G. M. Bray

      Pages 57-75

   4. The Development of Electrical Excitability

      • N. C. Spitzer

      Pages 77-91

   5. Group on Ontogeny

      • T. A. Sears

      Pages 92-92

   6. Ontogeny State of the Art Report

      • G. R. Strichartz, A. J. Aguayo, W. M. Cowan, H. Distel, L. Lim, G. M. McKhann et al.

      Pages 93-114

6. Maintenance

   1. Cellular and Non-Cellular Influences on Myelin-Forming Cells

      • R. P. Bunge

      Pages 115-130

   2. Cell Interactions and the Cytoskeleton

      • F. Solomon

      Pages 131-145

   3. Signalling Between Neuronal and Glial Cells

      • R. K. Orkand

      Pages 147-157

   4. Aspects of Receptor Systems Possibly Relevant to Neuron-Glial Interactions and Multiple Sclerosis

      • D. M. Fambrough

      Pages 159-167

   5. Group on Maintenance

      • T. A. Sears

      Pages 168-168

   6. Maintenance State of the Art Report

      • P. A. Walicke, D. A. Brown, R. P. Bunge, A. N. Davison, B. Droz, D. M. Fambrough et al.

      Pages 169-202

7. Injury

   1. Mechanisms of Tissue Damage in the Nervous System

      • B. G. W. Arnason, B. H. Waksman

      Pages 203-215

   2. Mechanism of Viral Injury to the Nervous System

      • B. N. Fields, H. L. Weiner

      Pages 217-228

   3. Mechanisms of Cell Injury by Certain Protein Toxins

      • A. M. Pappenheimer Jr.

      Pages 229-249

   4. Distribution and Functional Significance of Sodium and Potassium Channels in Normal and Acutely Demyelinated Mammalian Myelinated Nerve

      • J. M. Ritchie

      Pages 251-269

need for an interdisciplinary approach to research, although scientifically desirable and laudable, is not easily met by the individual investigator, a statement which I must now qualify lest it be taken as a faint-hearted view of the problems which confront us in this or any other field of disease-orientated re­ search. In recent years the growth and scope of MS research parallels, in fact reflects, that which has occurred more generally concern­ ing research at all levels of complexity into the nature and modes of operation of the nervous systems of different animals. With respect to these developments Cowan (2) has observed that "this has led to the gradual emergence of a new, interdisciplinary ap­ proach to the study of the nervous system which has come to be known as Neuroscience. " At the center of neuroscience stands man striving to comprehend hirnself, not only in terms of the nuts and bolts of his own ner­ vous system and that of lower animals, but perhaps preoccupied most of all with the higher level nervous functions of perception, volition, cognition, and mentation, which characterize his "self. " The investigation of these processes depends ultimately on re­ search on man hirnself and the analysis of these processes in depth often must wait on Nature's own experiments to provide, through disease, the chance anatomical or biochemical lesions which dissect human behavior and expose the residual functions for scientific study.

• Multiple Sklerose
• animals
• behavior
• cell
• complexity
• cytoskeleton
• development
• experiment
• glia
• growth
• influence
• membrane
• neuroscience
• system
• tissue

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