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The Obese Strain (OS) of Chickens With Spontaneous Autoimmune Thyroiditis: Review of Recent Data

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Current Topics in Microbiology and Immunology

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 91))

Abstract

The Obese strain (OS) of chickens was developed about 15 years ago by selective breeding for the phenotypic trait of hypothyroidism [1, 2]. The fact that the clinical symptoms are attributable to a spontaneously arising thyroiditis which is autoimmune in nature was first recognized 5 years later [3]. In subsequent years this avian model was established as the closest counterpart to human Hashimoto’s disease [4]; the data accumulated by 1974 have already been presented in a comprehensive review [5].

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Abbreviations

ADCC:

antibody-dependent cellular cytotoxicity

BSA:

bovine serum albumin

CS:

Cornell C strain

DCC:

direct cellular cytotoxicity

EAE:

experimental allergic encephalomyelitis

EAT:

experimentally induced autoimmune thyroiditis

FITC:

fluorescein isothiocyanate

MCA:

microcytotoxicity assay

MHC:

major histocompatibility complex

NWL:

normal White Leghorn

OS:

Obese strain

PHA:

phytohemagglutinin

RBC:

red blood cells

RFC:

rosette-forming cells

RSV:

Rous sarcoma virus

SAT:

spontaneous autoimmune thyroiditis

SCC:

spontaneous cellular cytotoxicity

TA-CRBC:

tannic acid only treated chicken red blood cells

Tg:

thyroglobulin

Tg-CRBC:

chicken red blood cells coated with thyroglobulin

TRITC:

tetramethylrhodamine-isothiocyanate

TSH:

thyroid stimulating hormone

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Author information

Authors and Affiliations

  1. Institute for General and Experimental Pathology, University of Innsbruck, Austria

    G. Wick, R. Boyd, K. Hala, R. Kofler & P. U. Müller

  2. Department of Immunology, Middlesex Hospital, Medical Scholl, London, UK

    L. De Carvalho

  3. Department of Poultry Science, Cornell University, Ithaca, N.Y., USA

    R. K. Cole

Authors
  1. G. Wick
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  2. R. Boyd
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  3. K. Hala
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  4. L. De Carvalho
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  5. R. Kofler
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  6. P. U. Müller
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  7. R. K. Cole
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Editor information

Editors and Affiliations

  1. Philadelphia, USA

    W. Henle  & H. Koprowski  & 

  2. Martinsried, Germany

    P. H. Hofschneider

  3. Düsseldorf, Germany

    P. Koldovský

  4. Copenhagen, Denmark

    O. Maaløe

  5. Basle, Switzerland

    F. Melchers

  6. Gießen, Germany

    R. Rott

  7. Ladenburg/Heidelberg, Germany

    H. G. Schweiger

  8. Prague, Czech Republic

    L. Syruček

  9. Los Angeles, USA

    P. K. Vogt

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© 1981 Springer-Verlag Berlin Heidelberg

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Wick, G. et al. (1981). The Obese Strain (OS) of Chickens With Spontaneous Autoimmune Thyroiditis: Review of Recent Data. In: Henle, W., et al. Current Topics in Microbiology and Immunology. Current Topics in Microbiology and Immunology, vol 91. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-68058-8_5

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  • DOI: https://doi.org/10.1007/978-3-642-68058-8_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-68060-1

  • Online ISBN: 978-3-642-68058-8

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