Skip to main content
SpringerLink
Log in

Hormonal Control of Decidualization

  • Conference paper
Proteins and Steroids in Early Pregnancy

Abstract

The secretory pattern of ovarian hormones during the estrous cycle varies in mammals. In the human, estrogen secretion peaks twice during a cycle, once shortly before ovulation and again at the mid-luteal phase. The progesterone level, on the other hand, is very low before ovulation. After ovulation it increases to peak at the mid-luteal phase, then declines to a low level prior to the next menstruation (Ross et al. 1970, Edwards 1980). Since ovum implantation in the human occurs about 8 days after ovulation, the increased secretion of estrogen and progesterone during the luteal phase appears to be necessary to prepare the endometrium for the fertilized ovum and subsequent decidualization.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Log in via an institution
Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as EPUB and PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Alloiteau J-J, Vignai A (1958) Pseudogestation apres injection de progesterone chez la ratte. C R Acad Sci (Paris) 246:2804–2810

    CAS  Google Scholar 

  • Arimura A, Nishi N, Schally AV (1976) Delayed implantation caused by administration of sheep immunogammaglobulin against LHRH in the rat. Proc Soc Exp Biol Med 152:71–75

    PubMed  CAS  Google Scholar 

  • Atkinson LE, Hotchkiss J, Fritz GR, Surve AH, Neill JD, Knobil E (1975) Circulating levels of steroids and chorionic gonadotropin during pregnancy in the rhesus monkey, with special attention to the rescue of the corpus luteum in early pregnancy. Biol Reprod 12:335–345

    Article  PubMed  CAS  Google Scholar 

  • Bindon BM (1969) Follicle-stimulating hormone content of the pituitary gland before implantation in the mouse and rat. J Endocrinol 44:349–356

    Article  PubMed  CAS  Google Scholar 

  • Bindon BM (1971) Gonadotrophin requirements for implantation in the mouse. J Endocrinol 50:19–27

    Article  PubMed  CAS  Google Scholar 

  • Bloch S (1973) Nidation induced in mice during the lactational delay by the presence of strange males. J Endocrinol 57:185–186

    Article  PubMed  CAS  Google Scholar 

  • Browning JY, Keyes PL, Wolf RC (1980) Comparison of serum progesterone, 20α-dihydroprogesterone, and estradiol-17ß in pregnant and pseudopregnant rabbits: evidence for postimplantation recognition of pregnancy. Biol Reprod 23:1014–1019

    Article  PubMed  CAS  Google Scholar 

  • Canivenc R, Laffargue M, Mayer G (1956) Nidations retardees chez la ratte castree et injectee de progesterone: influence du moment de la castration sur la chronologie de l’ovo-implantation. C R Soc Biol (Paris) 150:2208–2212

    CAS  Google Scholar 

  • Chambon Y (1949) Besoins endocriniens qualitatifs et quantitatifs de l’ovoimplantation chez la lapine. C R Soc Biol 143:1172–1175

    CAS  Google Scholar 

  • Cochrane RL, Meyer RK (1957) Delayed nidation in the rat induced by progesterone. Proc Soc Exp Biol Med 96:155–159

    PubMed  CAS  Google Scholar 

  • Deanesly R (1960) Implantation and early pregnancy in ovariectomized guinea-pigs. J Reprod Fertil 1:242–248

    Article  Google Scholar 

  • DeFeo VJ (1967) Decidualization. In: Wynn RM (ed) Cellular biology of the uterus. Appleton-Century-Crofts, New York, pp 191–290

    Google Scholar 

  • Edwards RG (1980) Conception in the human female. 1st Edition, Academic Press, London, New York, Toronto, Sydney, San Francisco

    Google Scholar 

  • Ershoff BH, Deuel HJ Jr (1943) Prolongation of pseudopregnancy in induction of deciduomata in the rat. Proc Soc Exp Biol Med 54:167–168

    Google Scholar 

  • Ford JJ, Melampy RM (1973) Gonadotropin levels in lactating rats: Effect of ovariectomy. Endocrinology 93:540–547

    Article  PubMed  CAS  Google Scholar 

  • Freeman ME, Smith MS, Nazian SJ, Neill JD (1974) Ovarian and hypothalamic control of the daily surges of prolactin secretion during pseudopregnancy in the rat. Endocrinology 94:875–882

    Article  PubMed  CAS  Google Scholar 

  • Gibori G, Rothchild I, Pepe GJ, Morishige WK, Lam P (1974) Luteotrophic action of decidual tissue. Endocrinology 95:1113–1118

    Article  PubMed  CAS  Google Scholar 

  • Hashimoto I, Henricks DM, Anderson LL, Melampy RM (1968) Progesterone and pregn-4-en-20α-ol-3-one in ovarian venous blood during various reproductive states in the rat. Endocrinology 82:333–341

    Article  PubMed  CAS  Google Scholar 

  • Hayashida T, Young WP (1963) Interruption of pregnancy in rats with antiserum. Anat Ree 145:323–324

    Google Scholar 

  • Hotchkiss J, Atkinson LE, Knobil E (1971) Time course of serum estrogen and luteinizing hormone (LH) concentrations during the menstrual cycle of the rhesus monkey. Endocrinology 89:177–183

    Article  PubMed  CAS  Google Scholar 

  • Joshi HS, Labhsetwar AP (1972) The pattern of ovarian secrouse of oestradiol and oestrone during pregnancy and the post partum period in the hamster. J Reprod Fertil 31:299–302

    Article  PubMed  CAS  Google Scholar 

  • Krehbiel RH (1941) The effects of Theelin on delayed implantation in the pregnant lactating rat. Anat Ree 81:381–392

    Article  CAS  Google Scholar 

  • Keyes PL, Nalbandov AV (1967) Maintenance and function of corpora lutea in rabbits depend on estrogen. Endocrinology 80:938–946

    Article  PubMed  CAS  Google Scholar 

  • Lee C, Keyes PL, Jacobson HI (1971) Estrogen receptor in rabbit corpus luteum. Science 173:1032–1033

    Article  PubMed  CAS  Google Scholar 

  • Lin YC, Yoshinaga K (1976a) Inhibitory effect of Gn-RH on ovum implantation in the rat. 58th Annual Meeting of the Endocrine Society, June 23–25 1976, San Francisco, Abstract

    Google Scholar 

  • Lin YC, Yoshinaga K (1976b) Chronic effects of Gn-RH on the pituitary ovarian axis in pseudopregnant rats. 9th Annual Meeting of the Society for the Study of Reproduction; August 10–13, Philadelphia, Abstract

    Google Scholar 

  • Macdonald GJ, Armstrong DT, Greep RO (1967) Initiation of blastocyst implantation by luteinizing hormone. Endocrinology 80:172–176

    Article  PubMed  CAS  Google Scholar 

  • Madhwa Raj HG, Sairam MR, Moudgal NR (1968) Involvement of luteinizing hormone in the implantation process of the rat. J Reprod Fertil 17:335–341

    Article  Google Scholar 

  • Meyer RK, Wolf RC, Arslan M (1970) Implantation and maintenance of pregnancy in progesteronetreated ovariectomized monkeys (Macaca mulatta) In: Experimental medicine and surgery in primates (Goldsmith EI and Moore-Jankowski J (eds) Proc 2 nd Conference New York 1969, Karger, Basel, pp 30–35

    Google Scholar 

  • Mougdal NR, Behman HR, Greep RO (1972) Effect of luteinizing hormone antiserum on progestrone and 200dihydroprogesterone secretion in the pregnant rat. J Endocrinol 52:413–418

    Article  Google Scholar 

  • Mougdal NR, Rao AJ, Maneckjee R, Muralidhar K, Mukku V, Rani CSS (1974) Gonadotropins and their antibodies. Recent Prog Horm Res 30:47–71

    Google Scholar 

  • Murr SM, Bradford GE, Geschwind II (1974) Plasma luteinizing hormone, follicle stimulating hormone and prolactin during pregnancy in the mouse. Endocrinology 94:112–116

    Article  PubMed  CAS  Google Scholar 

  • Nimrod A, Ladany S, Lindner HR (1972) Perinidatory ovarian oestrogen secretion in the pregnant rat, determined by gas Chromatograph with electron capture detection. J Endocrinol 53:249–260

    Article  PubMed  CAS  Google Scholar 

  • Norris ML, Adams CE (1971) Delayed implantation in the Mongolian gerbil, Meriones unguiculatus. J Reprod Fertil 27:486–487

    Article  PubMed  CAS  Google Scholar 

  • Orsini MW, Meyer RK (1962) Effect of varying doses of progesterone on implantation in the ovariectomized hamster. Proc Soc Exp Biol Med 110:713–715

    CAS  Google Scholar 

  • Pencharz RI, Long JA (1931) The effect of hypophysectomy on gestation in the rat. Science 74:206

    Article  PubMed  CAS  Google Scholar 

  • Pope GS, Waynforth HB (1970) Secretion of oestrogens into the ovarian venous blood of pregnant rats. J Endocrinol 48:i–ii

    Article  PubMed  CAS  Google Scholar 

  • Psychoyos A (1963) Precisions sur l’etat de “non-receptivite” de l’uterus. C R Acad Sci (Paris) 257:1153–1156

    CAS  Google Scholar 

  • Raud HR (1974) The regulation of ovum implantation in the rat by endogenous and exogenous FSH and prolactin: posibble role of ovarian follicles. Biol Reprod 10:327–334

    Article  PubMed  CAS  Google Scholar 

  • Ross GT, Cargill CM, Lipsett MB, Rayford PL, Marshall JR, Strott CA, Rodbard D (1970) Pituitary and gonadal hormones in women during spontaneous and induced ovulatory cycles. Recent Prog Horm Res 26:1–26

    PubMed  CAS  Google Scholar 

  • Shaikh AA (1971) Estrone and estradiol levels in the ovarian venous blood from rats during the estrous cycle and pregnancy. Biol Reprod 5:297–307

    PubMed  CAS  Google Scholar 

  • Shaikh AA, Abraham GE (1969) Measurement of estrogen surge during pseudopregnancy in rats by radioimmunoassay. Biol Reprod 1:378–380

    Article  PubMed  CAS  Google Scholar 

  • Shelesnyak MC (1960) Nidation of the fertilized ovum. Endeavour 19:81–86

    Article  CAS  Google Scholar 

  • Smith MS, Freeman ME, Neill JD (1975) The control of progesterone secretion during the estrous cycle and early pseudopregnancy in the rat: prolactin, gonadotropin and steroid levels associated with rescue of the corpus luteum of pseudopregnancy. Endocrinology 96:219–226

    Article  PubMed  CAS  Google Scholar 

  • Takahashi M, Ford JJ, Yoshinaga K, Creep RO (1975) Effects of cervical stimulation and anti-LH releasing hormone serum on LH releasing hormone content in the hypothalamus. Endocrinology 96:453–457

    Article  PubMed  CAS  Google Scholar 

  • Watson J, Anderson FB, Alam M, O’Grady JE, Heald PJ (1975) Plasma hormones and pituitary luteinizing hormone in the rat during the early stages of pregnancy and after post-coital treatment with Tamoxifen (ICI 46,474). J Endocrinol 65:7–17

    Article  PubMed  CAS  Google Scholar 

  • Weichert CK (1941) The effectiveness of estrogen in shortening delayed pregnancy in the rat. Anat Ree 81:106

    Google Scholar 

  • Yochim JM, DeFeo VJ (1963) Hormonal control of the onset, magnitude and duration of uterine sensitivity in the rat by steroid hormones of the ovary. Endocrinology 72:317–326

    Article  PubMed  CAS  Google Scholar 

  • Yoshinaga K (1961) Effect of local application of ovarian hormones on the delay in implantation in lactating rats. J Reprod Fertil 2:35–41

    Article  PubMed  CAS  Google Scholar 

  • Yoshinaga K (1972) Suppression of ovarian cyclic activity by deciduoma in the rat. Anat Ree 172:432 (Abstract)

    Google Scholar 

  • Yoshinaga K (1974) Ovarian progestin secretion in lactating rats: Effect of intrabursal injection of prolactin-antiserum, prolactin and LH. Endocrinology 94:829–834

    Article  PubMed  CAS  Google Scholar 

  • Yoshinaga K (1976) Ovarian hormone secretion and ovum implantation. In: Yoshinaga K, Meyer RK, Greep RO (eds) Implantation of the ovum. Harvard University Press, Cambridge, Massachusetts, pp 3–17

    Google Scholar 

  • Yoshinaga K (1977) Hormonal interplay in the establishment of pregnancy. In: Greep RO (ed) International review of physiology. Reproductive physiology II. University Park Press, Baltimore, pp 201–223

    Google Scholar 

  • Yoshinaga K (1979) Suppression of ovarian function by LHRH and its analogues in pregnant rats. In: Ovarian follicular and corpus luteum function (Channing CP, Marsh JM, Sadler WA eds) Plenum Publish Corp, New York pp 729–734

    Google Scholar 

  • Yoshinaga K (1980) Inhibition of implantation by advancement of uterine sensitivity and refractoriness. In: Blastocyst-endometrium relationships (Leroy F, Finn CA, Psychoyos A, Hubinont PO, eds) Progr reprod biol Vol 7, Karger, Basel, pp 189–199

    Google Scholar 

  • Yoshinaga K (1981) Induction of delayed implantation in rats by LH-RH. J Reprod Fertil Suppl 29:131–133

    PubMed  CAS  Google Scholar 

  • Yoshinaga K, Adams CE (1966) Delayed implantation in the spayed, progesterone treated adult mouse. J Reprod Fertil 12:593–595

    Article  PubMed  CAS  Google Scholar 

  • Yoshinaga K, Adams CE (1967) Luteotrophic activity of the young conceptus in the rat. J Reprod Fertil 13:505–509

    Article  PubMed  CAS  Google Scholar 

  • Yoshinaga K, Greep RO (1970) Precocious sensitization of the uterus in pseudopregnant rats. Proc Soc Exp Biol Med 134:725–727

    PubMed  CAS  Google Scholar 

  • Yoshinaga K, Greep RO (1974) Uterine sensitivity with regard to ovo-implantation. In: Husain SM, Guttmacher AF (eds) Progress in reproduction research and population control. Publications International, Quebec, pp 137–146

    Google Scholar 

  • Yoshinaga K, Pincus G (1963) Local effect of estrogen on cholesterol synthesis in the uterus of ovariectomized rats. Steroids 1:656–663

    Article  CAS  Google Scholar 

  • Yoshinaga K, Hawkins RA, Stocker JF (1969) Estrogen secretion by the rat ovary in vivo during the estrous cycle and pregnancy. Endocrinology 85:103–112

    Article  PubMed  CAS  Google Scholar 

  • Yoshinaga K, Mougdal NR, Greep RO (1971) Progestin secretion by the ovary in lactating rats: Effects of LH-antiserum, LH and prolactin. Endocrinology 88:1126–1130

    Article  PubMed  CAS  Google Scholar 

  • Zeilmaker GH (1963) Experimental studies on the effects of ovariectomy and hypophysectomy on blastocyst implantation in the rat. Acta Endocrinol (Kbh) 44:355–366

    PubMed  CAS  Google Scholar 

Download references

Author information

Author notes

  1. Koji Yoshinaga

    Present address: Reproductive Sciences Branch, Center for Population Research, NICHD, NIH, Bethesda, MD, 20205, USA

Authors and Affiliations

  1. Laboratory of Human Reproduction and Reproductive Biology and Department of Anatomy, Harvard Medical School, Boston, Massachusetts, USA

    Koji Yoshinaga

Authors
  1. Koji Yoshinaga
    View author publications

    You can also search for this author in PubMed Google Scholar

Editor information

Editors and Affiliations

  1. Abteilung Anatomie und Reproduktionsbiologie, Medizinische Fakultät der RWTH Aachen, D-5100, Aachen, Federal Republic of Germany

    Henning M. Beier

  2. Institut für Physiologische Chemie I, Medizinische Fakultät der Philipps-Universität, D-3550, Marburg/Lahn, Federal Republic of Germany

    Peter Karlson

Rights and permissions

Reprints and permissions

Copyright information

© 1982 Springer-Verlag Berlin Heidelberg

About this paper

Cite this paper

Yoshinaga, K. (1982). Hormonal Control of Decidualization. In: Beier, H.M., Karlson, P. (eds) Proteins and Steroids in Early Pregnancy. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67890-5_3

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-67890-5_3

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67892-9

  • Online ISBN: 978-3-642-67890-5

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics

Search

Navigation