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Locus and Mechanism of Action of Ganglion-Blocking Agents

  • Chapter
Pharmacology of Ganglionic Transmission

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 53))

Abstract

Paton and Perry (1953) classified ganglion-blocking drugs “according to whether they act like acetylcholine or by preventing its action”. They termed the former “depolarizing” and the latter “competitive” blocking drugs. They excluded “drugs such as local anaesthetics, which interfere with ganglionic transmission by preventing the release of acetylcholine”, implying that true ganglion-blocking drugs have no such action (a thesis discussed further below).

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  1. Department of Pharmacology, First Medical Institute, 2/6, B. Pirogovskaja St., 119435, Moscow, USSR

    Dimitry A. Kharkevich

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Brown, D.A. (1980). Locus and Mechanism of Action of Ganglion-Blocking Agents. In: Kharkevich, D.A. (eds) Pharmacology of Ganglionic Transmission. Handbook of Experimental Pharmacology, vol 53. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67397-9_7

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