Pharmacology of Ganglionic Transmission

1. Front Matter

   Pages I-XV

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2. Introduction

   • D. A. Kharkevich

   Pages 1-8

3. Ganglionic Transmission: Morphology and Physiology

   • V. I. Skok

   Pages 9-39

4. Ganglionic Metabolism

   • J. D. Klingman, D. T. Organisciak, G. I. Klingman

   Pages 41-61

5. Methods for the Examination of Ganglion-Blocking Activity

   • L. Gyermek

   Pages 63-121

6. Relationship Between Chemical Structure and Ganglion-Blocking Activity

   • V. Trčka

   Pages 123-153

7. Relationship Between Chemical Structure and Ganglion-Blocking Activity

   • V. Trčka

   Pages 155-184

8. Locus and Mechanism of Action of Ganglion-Blocking Agents

   • D. A. Brown

   Pages 185-235

9. Action of Ganglion-Blocking Agents on the Cardiovascular System

   • D. M. Aviado

   Pages 237-253

10. Action of Ganglion-Blocking Agents on the Gastrointestinal Tract

    • D. F. J. Mason

    Pages 255-266

11. Absorption, Distribution, Fate, and Excretion of Ganglion-Blocking Compounds

    • D. F. J. Mason

    Pages 267-279

12. Nicotinic Ganglion-Stimulating Agents

    • R. L. Volle

    Pages 281-312

13. Non-Nicotinic Chemical Stimulation of Automatic Ganglia

    • W. E. Haefely

    Pages 313-357

14. Ganglion Activity of Centrally Acting Neurotropic Agents

    • A. Nistri, J. P. Quilliam

    Pages 359-384

15. Ganglionic Actions of Anticholinesterase Agents, Catecholamines, Neuro-Muscular Blocking Agents, and Local Anaesthetics

    • R. L. Volle

    Pages 385-410

16. Ganglionic Activity of Cardiovascular Drugs

    • D. M. Aviado

    Pages 411-415

17. Ganglion-Blocking Agents in Internal Medicine

    • E. V. Erina

    Pages 417-438

18. Ganglion-Blocking Agents in Anaesthesiology

    • A. A. Bunatian, A. V. Meshcherjakov

    Pages 439-463

19. Back Matter

    Pages 465-534

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D.A. KHARKEVICH The history of the study of ganglionic substances begins with the paper of LANGLEY and DICKINSON (1889), who established the ability of nicotine to block the neurones in the superior cervical ganglion. This was a considerable discovery as the authors ascertained that impulses were transmitted from pre- to postganglionic neurones in the autonomic ganglia. Simultaneously they indicated the possibility of pharmaco­ logical influence upon interneuronal transmission in autonomic ganglia. The idea of ganglionic receptors specifically sensitive to nicotine followed logically. Later, LANGLEY (1905, 1906) considered the problem of receptors with respect to neuro-effector synapses. It is remarkable that he was one of the first to put forward the theory of chemical mediation of excitation (" ... the nervous impulse should not pass from nerve to muscle by an electric discharge, but by the secretion of a special substance at the end of the nerve": LANGLEY, 1906, p. 183). In addition, LANGLEY JOHN N. LANGLEY (1852-1926) D.A. KHARKEVICH 2 and his collaborators managed to define the topography of autonomic ganglia more precisely by means of nicotine. It should be mentioned that it was he who introduced the terms "autonomic nervous system" and "parasympathetic nervous system".

• Acetylcholin
• Butyrophenone
• CNS
• Histamin
• Hormone
• Nicotin
• Phenothiazine
• Rauwolfia
• Thioxanthene
• alkaloids
• analgesics
• metabolism
• pharmacology
• physiology
• toxicity

• Department of Pharmacology, First Medical Institute, Moscow, USSR

  Dimitry A. Kharkevich

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