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Relationship Between Chemical Structure and Ganglion-Blocking Activity

a) Quarternary Ammonium Compounds

  • Chapter
Pharmacology of Ganglionic Transmission

Part of the book series: Handbook of Experimental Pharmacology ((HEP,volume 53))

Abstract

The discovery of drugs bringing about blockade of sympathetic ganglia has been an important step in the development of modern antihypertensive therapy. Partially successful clinical use of tetraethylammonium had initiated the synthesis and pharmacological studies on more than one thousand new substances with one or two quaternary nitrogen atoms in the molecule. It has been intended to find a drug with higher ganglion-blocking activity and long lasting hypotensive effect with less side-effects. These studies have led to the development of several drugs which were used for some years in therapeutic practice. Tetraethylammonium (1), hexa-methonium (2), pentolinium (3), chlorisondamin (4), azamethonium (5), trimethydinium (6) and pentacynium (7) were the most important of them (see Fig. 1).

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Authors
  1. V. Trčka
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Editors and Affiliations

  1. Department of Pharmacology, First Medical Institute, 2/6, B. Pirogovskaja St., 119435, Moscow, USSR

    Dimitry A. Kharkevich

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Trčka, V. (1980). Relationship Between Chemical Structure and Ganglion-Blocking Activity. In: Kharkevich, D.A. (eds) Pharmacology of Ganglionic Transmission. Handbook of Experimental Pharmacology, vol 53. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67397-9_5

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  • DOI: https://doi.org/10.1007/978-3-642-67397-9_5

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-67399-3

  • Online ISBN: 978-3-642-67397-9

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