Abstract
During the ensuing discussion M. MICKSCHE, C. CERNI, P. FISCHER, and M. VETTERLEIN reported on “tumor-associated antigens on somatic cell hybrids derived from human lung cancer cells.” In 1971 a squamous cell carcinoma of the lung was established as a continuously growing cell line in culture (E-14 line). Somatic cell hybrids were produced between the E-14 line and a hamster fibroblast cell line. A karyotype analysis revealed the presence of human chromosomes in the cell hybrids designated M10 and M29. Expression of tumor-associated antigens on hybrid cells and E-14 cells was demonstrated by means of an antiserum against E-14 cells produced in rabbits and tested by indirect immunofluorescence.
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References
HOLLINSHEAD, A.C., STEWART, T.H.M., HERBERMAN, R.B.: J. Natl. Cancer Inst. 52, 327–338 (1974)
MICKSCHE, M., CERNI, C., KOKOSCHKA, E.M., WRBA, H.: Biological characterization of human tumours. Exc. Med. 375, 337–345 (1975)
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© 1979 Springer-Verlag Berlin Heidelberg
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Micksche, M., Cerni, C., Fischer, P., Vetterlein, M. (1979). Discussion. In: Flad, HD., Herfarth, C., Betzler, M. (eds) Immunodiagnosis and Immunotherapy of Malignant Tumors. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-67166-1_11
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DOI: https://doi.org/10.1007/978-3-642-67166-1_11
Publisher Name: Springer, Berlin, Heidelberg
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