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Immunodiagnosis and Immunotherapy of Malignant Tumors

Relevance to Surgery

  • Conference proceedings
  • © 1979

Overview

Editors:
  1. Hans-Dieter Flad

    1. Abteilung Mikrobiologie, Laborbereich Immunologie, Universität Ulm, Ulm, Germany

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  2. Christian Herfarth

    1. Allgemeine Chirurgie, Universität Ulm, Ulm, Germany

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  3. Michael Betzler

    1. Allgemeine Chirurgie, Universität Ulm, Ulm, Germany

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Table of contents (40 papers)

  1. Front Matter

    Pages I-XII
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  2. Pathophysiologic Aspects of Tumor Development

    1. Front Matter

      Pages 1-1
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    2. Cellular Kinetics of Malignant Tumors

      • T. M. Fliedner
      Pages 3-10

    3. Fetal Patterns in Adult Rat Liver Undergoing Reparative and Neoplastic Growth

      • J. Uriel
      Pages 11-19

    4. Immunologic Studies on Rat Bowel Carcinomas

      • H. O. Sjögren
      Pages 20-28

    5. Discussion

      • J. Kusche, C. D. Stahlknecht
      Pages 29-30

  3. Clinical Significance of Immunologic Tests for Tumor Diagnosis

    1. Front Matter

      Pages 31-31
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    2. Tumor-Associated Antigens

      1. Clinical Significance of Carcinofetal Antigens with Special Reference to CEA, AFP, and Related Substances
        • S. von Kleist
        Pages 33-41
      2. Immunodiagnosis of Gastric Cancer and Related Diseases; Deletion, Neoantigen, and Nonspecific Factors
        • W. Rapp, K-H. Wurster
        Pages 42-49
      3. Humoral and Cellular Immune Reactions to CEA
        • B. Heymer, A. Quentmeier, G. Horn, O. Haferkamp
        Pages 50-55
      4. Tumor-Associated Antigens in Bronchogenic Carcinoma
        • K. Havemann, C. Gropp, F.-G. Lehmann, P. Preisser, S. von Kleist
        Pages 56-64
      5. Tumor-Associated Antigens and Immunity in Prostatic Carcinoma
        • R. J. Ablin, R. A. Bhatti, P. D. Guinan
        Pages 65-80
      6. Expression of Tumor-Associated Surface Antigens and Their Correlation to Parameters of Malignancy in Human Malignant Melanoma
        • C. Sorg, J. Brüggen, V. Klimetzek, E. Macher
        Pages 81-90
      7. Discussion
        • M. Micksche, C. Cerni, P. Fischer, M. Vetterlein
        Pages 91-92

    3. Cell-Mediated Immune Reactions

      1. Correlation Between Nonspecific Immune Competence and Clinical Outcome of Breast, Colon, and Stomach Cancer
        • L. E. Hughes, C. Teasdale, J. F. Forbes, J. W. Hillyard, R. H. Whitehead
        Pages 95-102
      2. Immunocompetence Testing in Patients with One of the Common Operable Cancer — A Review
        • H. J. Wanebo, C. M. Pinsky, E. J. Beattie, H. F. Oettgen
        Pages 103-114
      3. Significance and Mechanism of T-Cell Depression in Cancer
        • R. H. Whitehead, L. E. Hughes, H. S. Shukla
        Pages 115-121
      4. Cell-Mediated Immune Reactions in Patients with Colon Carcinoma
        • H. Warnatz
        Pages 122-128
      5. Significance of Spontaneous Lymphocyte-Mediated Cytotoxicity (SLMC) in Cancer Patients and Control Persons
        • H. H. Peter, I. Korn-Nitschmann, F. Krapf, H. C. Siewertsen, P. Schmidt, W. Leibold
        Pages 129-142
      6. Human Tumor-Lymphocyte Interaction in Vitro: Comparison of the Results with Autologous Tumor Stimulation (ATS) and Lymphocytotoxicity (ALC)
        • V. Vánky, B. M. Vose, M. Fopp, E. Klein, J. Stjernswärd
        Pages 143-152
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Keywords

About this book

The concept of immunologic responses against tumors is currently under intense scrutiny throughout the world. The evidence for the existence of tumor-specific transplantation antigens (TSTA) and specific immune reactions to them in experimental animals is overwhelming. The available data concerning human tumors are controversial. The reason for this is partially that antigens detectable on human tumors by in vitro assays have not been biologically characterized. In other words, we do not know if the antigens on human tumors are acting as the targets for immunologically mediated rejection processes in vivo. It was the purpose of this workshop to bring experimental tumor immunologists and clinical oncologists together in order to disclose facts and limits in tumor immunology. Clinicians were to learn how shaky the ground becomes once the experimentalist looks beyond the edge of the mouse cage. Tumor biologists heard the clinicians' urgent cry for controlled randomized trials of immunotherapy which thus reflects clearly that immunotherapy in its present form without knowledge of dose-effect-relationship does not work. Nobody would deny that the problem of human cancer smells of immunology, but since we are just about to taste it the essential ingredient might be different. In other words one might look at present rather at immunological epiphenomena than at mechanisms of tumor immul1lty operating in vivo. This problem was among others a central issue of this workshop.

Editors and Affiliations

  • Abteilung Mikrobiologie, Laborbereich Immunologie, Universität Ulm, Ulm, Germany

    Hans-Dieter Flad

  • Allgemeine Chirurgie, Universität Ulm, Ulm, Germany

    Christian Herfarth, Michael Betzler

Bibliographic Information

  • Book Title: Immunodiagnosis and Immunotherapy of Malignant Tumors

  • Book Subtitle: Relevance to Surgery

  • Editors: Hans-Dieter Flad, Christian Herfarth, Michael Betzler

  • DOI: https://doi.org/10.1007/978-3-642-67166-1

  • Publisher: Springer Berlin, Heidelberg

  • eBook Packages: Springer Book Archive

  • Copyright Information: Springer-Verlag Berlin Heidelberg 1979

  • Softcover ISBN: 978-3-540-09161-5Published: 15 March 1979

  • eBook ISBN: 978-3-642-67166-1Published: 06 December 2012

  • Edition Number: 1

  • Number of Pages: XII, 331

  • Number of Illustrations: 18 b/w illustrations

  • Topics: Medicine/Public Health, general

  • Industry Sectors: Biotechnology, Health & Hospitals, Pharma

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