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Defibrinogenation with Thrombin-Like Snake Venom Enzymes

  • Chapter
Fibrinolytics and Antifibrinolytics

Abstract

Disappearance of plasma fibrinogen has been observed in man following the bite of venomous snakes, e.g., Agkistrodon rhodostoma (Reid and Thean, 1963), Bothrops atrox (Ghitis and Bonelli, 1963), Crotalus adamanteus (Weiss et al., 1969), Crotalus viridis (Mugneret, 1973), Cerastes cerastes (Straub, 1971), Echis carinatus (Weiss et al., 1973) and Vipera russellii (De Vries and Cohen, 1969). Fibrinogen depletion may be a consequence of direct prothrombin activation by the venom (E. carinatus), or of prothrombin activation via activation of factor X (V. russellii), of fibrinogenolysis (C. cerastes), or it may be initiated by a limited proteolytic action of snake venom enzymes, comparable to the action of thrombin on fibrinogen, leading to formation and secondarv degradation of fibrin-related material.

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    F. Markwardt

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Stocker, K. (1978). Defibrinogenation with Thrombin-Like Snake Venom Enzymes. In: Markwardt, F. (eds) Fibrinolytics and Antifibrinolytics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66863-0_13

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