Fibrinolytics and Antifibrinolytics

  • F. Markwardt

Table of contents

  1. Front Matter
    Pages I-XXI
  2. The Fibrinolytic Process

    1. Front Matter
      Pages 1-1
    2. B. Blombäck
      Pages 49-79
    3. M. Kopeć, Z. S. Latallo
      Pages 81-105
    4. I. M. Nilsson, U. Hedner, M. Pandolfi
      Pages 107-134
  3. Activators of Fibrinolysis

    1. Front Matter
      Pages 135-135
    2. F. B. Taylor Jr., P. C. Comp
      Pages 137-149
    3. H.-P. Klöcking
      Pages 151-177
    4. G. Vogel
      Pages 179-207
    5. F. Duckert
      Pages 209-237
    6. P. C. Desnoyers
      Pages 273-314
  4. Fibrinolytically Active Enzymes

    1. Front Matter
      Pages 315-315
    2. K. C. Robbins
      Pages 317-336
    3. W. H. E. Roschlau
      Pages 337-450
  5. Antifibrinolytics

    1. Front Matter
      Pages 485-485
    2. F. Markwardt
      Pages 511-577

About this book

Introduction

Disturbances of haemostasis and thromboembolic disorders still constitute a great problem in clinical practice. Increasing insight into the mechanism of blood coagula­ tion has led to more effective therapy and prophylaxis. Particularly, the understand­ ing of the biochemistry of fibrinolysis has provided possibilities for the pharma­ cological interference of these processes, which has resulted in effective haemostatic agents and useful antithrombotic ones. The development of antifibrinolytics for interfering with pathological fibrinolytic processes is nearly complete and has led to the development of drugs essential to the therapy of hyperfibrinolytic bleeding. The search for fibrinolytics for dissolving intravascular thrombi has led to highly effective compounds. This development is still under way and promising results are hoped. Spontaneous dissolution of blood clots is a phenomenon which was described a century ago. First investigations of this process assured that there is in the organism a system capable of removing the fibrin which is formed during blood coagulation after it has fulfilled its physiological function. This fibrinolytic system is specifically adapted to the degradation of insoluble fibrin into soluble degradation products. In the past 30 years, thorough investigation of this system has clarified the fibrinolytic process, its physiological role and its meaning as a pathogenetic principle. A good knowledge of these processes is required for an understanding of the effects and side effects of fibrinolytics and antifibrinolytics, which comprise the basis of methods for the detection of fibrinolytic processes in the organism and of the control of therapy with these drugs.

Keywords

Antifibrinolytikum Fibrinolytikum biochemistry chemistry research therapy

Editors and affiliations

  • F. Markwardt
    • 1
  1. 1.Institut für Pharmakologie und ToxikologieMedizinische Akademie ErfurtErfurtGerman Democratic Republic

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-66863-0
  • Copyright Information Springer-Verlag Berlin Heidelberg 1978
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-66865-4
  • Online ISBN 978-3-642-66863-0
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book
Industry Sectors
Biotechnology
Pharma