Skip to main content

Indirect Fibrinolytic Agents

  • Chapter
Fibrinolytics and Antifibrinolytics

Abstract

The prophylaxis and treatment of thromboembolic disorders have long involved the use of anticoagulants administered either parenterally or via the oral route. However, at the present time, there is no longer unanimity regarding the effectiveness of this medication, due to the difficulties of objective assessment of all of the parameters of thromboembolic disease.

This is a preview of subscription content, log in via an institution to check access.

Access this chapter

Chapter
USD 29.95
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
eBook
USD 84.99
Price excludes VAT (USA)
  • Available as PDF
  • Read on any device
  • Instant download
  • Own it forever
Softcover Book
USD 109.99
Price excludes VAT (USA)
  • Compact, lightweight edition
  • Dispatched in 3 to 5 business days
  • Free shipping worldwide - see info

Tax calculation will be finalised at checkout

Purchases are for personal use only

Institutional subscriptions

Preview

Unable to display preview. Download preview PDF.

Unable to display preview. Download preview PDF.

References

  • Abiko, Y., Kumada, T.: Enhancement of fibrinolytic and thrombolytic potential in the rat by an anabolic steroid Furazabol. Thrombos. Res. 8 (Suppl. II), 107–14 (1976)

    Article  CAS  Google Scholar 

  • Adar, R., Salzman, E. W.: Treatment of thrombosis of veins of the lower extremities. New Engl. J. Med. 292, 348–50 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Ã…stedt, B., Jeppsson, S.: Thromboembolism and oral contraceptives. Brit. med. J. 1974II, 333

    Google Scholar 

  • Albrechtsen, O., Barfod, B., Barfod, E., Laursen, N. P. R., Nordentoft, B., Yde, H.: Hormonal treatment of arterial insufficiency in the lower extremities. Dan. med. Bull. 19, 157–159 (1972)

    PubMed  CAS  Google Scholar 

  • Allenby, F., Jeyasingh, K., Calnan, J.: Ethyloestrenol and postoperative venous thrombosis. Lancet 1973II, 38–39

    Google Scholar 

  • Ambrus, J. L., Ambrus, C. M., Stutzman, L., Schimert, G.: Therapeutic studies with fibrinolytic and antifibrinolytic agents. Abstr. Papers, Amer. chem. Soc. 155, 25 N (1968)

    Google Scholar 

  • Amery, A., Vermylen, J., Maes, H., Verstraete, M.: Influence d’un dérivé du niacin sur le système fibrinolytique de l’homme. Apparition de l’activité fibrinolytique après différents modes d’administration. Nouv. Rev. franç. Hémat. 2, 70–78 (1962)

    Google Scholar 

  • Andreenko, G. V., Migalina, G. A.: Mechanism of action of nicotinic acid in vitro and in vivo. Vopr. Med. Khim. 17, 423–27 (1971)

    PubMed  CAS  Google Scholar 

  • Ardlie, N. G., Glew, G., Schwartz, C. J.: Influence of catecholamines on nucleotide-induced platelet aggregation. Nature (Lond.) 212, 415–17 (1966)

    Article  CAS  Google Scholar 

  • Asbeck, F., Schuchardt, V., Schoop, W., van de Loo, J.: Induction of fibrinolytic activity by buformin and phenformin. A double blind clinical trial. In: Kaulla, K. N. von, Davidson J. F. (Eds.): Synthetic Fibrinolytic Thrombolytic agents, pp. 338–42. Springfield/III.: Thomas 1975

    Google Scholar 

  • Assan, R., Heuclin, C., Girard, J. R.: Limitations of use of phenformin. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol.1, pp. 351–356. New York: Raven 1975

    Google Scholar 

  • Astrup, T.: Fibrinolytic enzymes. Transactions of 1st Conference on blood clotting and allied problems. New York: Josiah Macy Jr Foundation 1948, p. 28

    Google Scholar 

  • Astrup, T., Nissen, U., Rasmussen, J.: Effects of preparations of heparin and heparitin sulfate on fibrinolysis. Arch. Biochem. 113, 634–40 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Augusti, K. T., Benaim, M. E., Dewar, H. A., Virden, R.: Partial identification of the fibrinolytic activators in onion. Atherosclerosis 21, 409–16 (1975)

    Article  PubMed  CAS  Google Scholar 

  • Back, N., Wilkens, H., Barlow, B., Czarnecki, J.: Fibrinolytic studies with biguanide derivatives. Ann. N.Y. Acad. Sci. 148, 691–713 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Battezzati, M., Belardi, P.: Terapia fibrinolitica indiretta da pirogeni. La Ricerca scient. No Spécial 27 (1965)

    Google Scholar 

  • Baumgartner, H. R., Studer, A., Reber, K.: Methods for the production of experimental thrombosis in the rabbit ear, and the significance of 5-hydroxytryptamine for its origination. Thrombos. Diathes. haemorrh. (Stuttg.) 9, 485–511 (1963)

    CAS  Google Scholar 

  • Baumgartner, H., Studer, A., Reber, K.: Influence of 5-hydroxytryptamine, 5-hydroxytryptophan, dopamine, norepinephrine, and reserpine on thrombotic deposits in the rabbit. Thrombos. Diathes. haemorrh. (Stuttg.) 12, 169–178 (1964)

    CAS  Google Scholar 

  • Beck, N. P., Kaneko, T., Zor, U., Field J. B., Davis, B. B.: Effect of vasopressin and prostaglandin E1 on the adenyl cyclase-cyclic 3′–5′ adenosine monophosphate system in the renal medulla of the rat. J. clin. Invest. 50, 2461–65 (1971)

    Article  PubMed  CAS  Google Scholar 

  • Belikina, N. V.: Mechanism of lipocain effect on hemocoagulation. In: Anikin, G.D. (Ed.): 6th Mater. Povolzh. Konf. Fiziol. Uchastiem. Biokhim. Farmakol. Morfol. Chuv. Gos. Univ. Cheboksary, URSS 1, 120–1 (1973)

    Google Scholar 

  • Beller, F. K., Sellin, D.: Fibrinolyse-Aktivierung durch eine Kombination von Nicotinsäure und Heparin. Arzneimittel-Forsch. 10, 758–763 (1960)

    CAS  Google Scholar 

  • Belli, C.: In vivo and in vitro analytical studies of the action of some biodynamical substances derived by chromaffin tissue on spontaneous fibrinolysis. Biol. Latina 16,771–782 (1963)

    CAS  Google Scholar 

  • Bick, R. L., Murano, G., Fekete, L., Wilson, W. L.: Daunomycin and fibrinolysis. Thrombos. Res. 9, 201–203 (1976)

    Article  CAS  Google Scholar 

  • Bielawiec, M., Lukjan, H.: Der Einfluß der Fibrinolyse-Aktivierung auf den peripheren Kreislauf bei obliterierenden Gefäßkrankheiten. Med. Mschr. 25, 312–314 (1971)

    PubMed  CAS  Google Scholar 

  • Bielawiec, M., Mysliwiec, M., Perzanowski, A.: Combined therapy with phenformin plus stanozolol in patients with occlusive arterial disease and recurrent venous thrombosis. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 3. New York: Raven 1978

    Google Scholar 

  • Bielski, J., Owczarek, L.: Histamine and blood clotting. Acta haemat. pol. 1, 47–53 (1970)

    CAS  Google Scholar 

  • Biggs, R., MacFarlane, R. G., Pilling, J.: Observations on fibrinolysis. Experimental activity produced by exercise or adrenalin. Lancet 1947I, 402–405

    Google Scholar 

  • Bizzi, B., Butti, A.: Valutazione clinica di un farmaco fibrinolitico in un disegno sperimentale cross-over. Minerva Med. 60 (Suppl. 99), 5062–5067 (1969)

    PubMed  CAS  Google Scholar 

  • Bobek, K., Cerhova, M., ÄŒepelak, V., Sidlova, A.: Serotonin and histamine in cases with venous thrombosis. Metab. Parietis Vasorum, Papers Intern. Congr. Angiol. 5 th, Prague 921–927 (1961)

    Google Scholar 

  • Bogomolova, E. K., Sukhanov, A. A., Yastrebova, L. P., Yampolskaya, L. A.: Effect of euphillin on the fibrinolytic system of the blood in patients with atherosclerosis and hypertensive disease. Klin. Med. 53, 51–53 (1975)

    CAS  Google Scholar 

  • Bouvier, C. A., Berthoud, S.: Effects on the human fibrinolytic system of intravenous infusions of high doses of Complamin, a nicotinic acid derivative. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol.3. New York: Raven 1978

    Google Scholar 

  • Britton, B. J., Wood, W. G., Peele, M., Hawkey, C., Irving, M. H.: The role of sympatho-adrenal stimulation in the release of plasminogen activator. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 1. New York: Raven 1975

    Google Scholar 

  • Britton, B. J., Wood, W. G., Smith, M., Hawkey, C., Irving, M. H.: The effect of beta adrenergic blockade upon exercise-induced changes in blood coagulation and fibrinolysis. Thrombos. Haemost. 35, 396–402 (1976)

    CAS  Google Scholar 

  • Brown, I. K.: Pharmacological stimulation of fibrinolytic activity in the surgical patient. Lancet 1971I, 774–776

    Google Scholar 

  • Bruhn, H. D.: Activation of fibrinolysis by furosemide. Thrombos. Diathes. haemorrh. (Stuttg.) 33, 672–673 (1975)

    CAS  Google Scholar 

  • Bruhn, H. D., Jipp, P., Okoye, S., Oltmann, A.: Hypofibrinolyse beim akuten Myokardinfarkt. Med. Klin. 69, 1951–1955 (1974)

    PubMed  CAS  Google Scholar 

  • Bruhn, H. D., Fricke, G., Schmidt, J., Niedermayer, W.: Fibrinolyseaktivierung durch Furosemid. Med. Klin. 70, 1125–1127 (1975)

    PubMed  CAS  Google Scholar 

  • Butler, S.: Experiments dealing with the relation of blood histamine to coagulation, hemoconcen-tration, and arterial blood pressure. Quart. Bull. Northw. Univ. med. Sch. 29, 100–105 (1955)

    PubMed  CAS  Google Scholar 

  • Cajozzo, A., Citarrella, P., Abbadessa, V., Di Marco, P.: Effetti della D-tiroxina sulla fibrinolisi e sulla adesivita ed aggregabilita piastrinici in soggetti aterosclerotici. Boll. Soc. ital. Biol. sper. 50, 984–990 (1974)

    PubMed  CAS  Google Scholar 

  • Cascone, A., Lampugnani, P.: Studio sperimentale controllato dei rapporti tra attivita fibrinolitica e attivita anticoagulante nella valutazione di attivatori della fibrinolisi. Minerva Med. 60 (Suppl. 99), 5039–5045 (1969)

    PubMed  CAS  Google Scholar 

  • Casertano, F., Piccinini, F.: Fibrinolytic action in vivo of histamine. Arch. E. Maragliano Pat. Clin. 15, 267–273 (1959)

    CAS  Google Scholar 

  • Cash, J. D.: Physiological aspects of fibrinolysis. In: Kaulla, K. N. von, Davidson, J. F. (Eds.): Synthetic Fibrinolytic Thrombolytic Agents, pp. 5–19. Springfield: C. Thomas 1975a

    Google Scholar 

  • Cash, J. D.: Short-term enhancement of plasminogen activator in vivo by drugs. Thrombos. Diathes. haemorrh. (Stuttg.) 34, 648–651 (1975b)

    CAS  Google Scholar 

  • Cash, J. D., Allan, A. G. E.: The fibrinolytic response to moderate exercise and intravenous adrenaline in the same subjects. Brit. J. Haematol. 13, 376–383 (1967)

    Article  CAS  Google Scholar 

  • Cash, J. D., Lind, A. R., McNicol, G. W., Woodfield, D. G.: Fibrinolytic and forearm blood flow responses to intravenous adrenaline in healthy subjects. Life Sci. 8, 207–213 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Cash, J. D., Woodfield, D. G., Allan, A. G. E.: Adrenergic mechanisms in the systemic plasminogen activator response to adrenaline in man. Brit. J. Haemat. 18, 487–494 (1970)

    Article  PubMed  CAS  Google Scholar 

  • Centonza, D., Brina, A., De Cristoforo, A.: Controllo e regolazione della fibrinolisi negli arteriopatici mediante l’impiego di un complesso mucopolisaccaridico estrattivo. Minerva Med. 60 (Suppl. 99), 5023–5033 (1969)

    PubMed  CAS  Google Scholar 

  • ÄŒepelák, V., Roubal, Z., KuchaÅ™, M.: Fibrinolysis induction by synthetic organic acids. Chemical structure and biological activity relationship. Folia haemat. (Lpz.) 103, 3: 343–350 (1976)

    Google Scholar 

  • Chakrabarti, R., Delitheos, A., Clarke, G. M.: Fibrinolytic activity in relation to age in survivors of myocardial infarction. Lancet 1966I, 573–574

    Google Scholar 

  • Chakrabarti, R., Fearnley, G. R.: Phenformin plus ethyloestrenol in survivors of myocardial infarction. Three-year pilot study. Lancet 1972II, 556–559

    Google Scholar 

  • Chakrabarti, R., Fearnley,G. R.: Reduction of platelet stickiness by phenformin plus ethyloestrenol. Lancet 1967II, 1012–1014

    Google Scholar 

  • Chakrabarti, R., Fearnley, G. R.: Effects of Clofibrate on fibrinolysis, platelet stickiness, plasma-fibrin ogen, and serum-cholesterol. Lancet 1968II, 1007–1009

    Google Scholar 

  • Chakrabarti, R., Fearnley, G. R., Hocking, E. D.: Effect of corticosteroid on fibrinolysis in patients with inflammatory and non inflammatory conditions. Brit. med. J. 1964I, 534–537

    Google Scholar 

  • Chakrabarti, R Hocking, E. D., Fearnley, G. R.:., Fibrinolytic effect of metformin in coronary-artery disease. Lancet 1965II, 256–259 (1965)

    Google Scholar 

  • Chakrabarti, R., Meade, T. W.: Trial of Clofibrate. Brit. med. J. 1972I, 247

    Google Scholar 

  • Chase, L. R., Aurbach, G. D.: Renal adenylcyclase: anatomically separate sites for parathyroid hormones and vasopressin. Science 159, 545–547 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Cho, M. H., Choy, W.: Induction of increased fibrinolytic activator in plasma by various drugs. Thrombos. Diathes. haemorrh. (Stuttg.) 11, 372–392 (1964)

    CAS  Google Scholar 

  • Coccheri, S., De Rosa, V., Cavallaroni, K., Poggi, M.: Activation of fibrinolysis by means of sulphated polysaccharides. Present status and perspectives. In: Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 3 (J. F. Davidson, M. Samama and P. Desnoyers, Eds.). New York:Raven 1978

    Google Scholar 

  • Constantini, R., Hilbe, G., Spöttl, F., Holzknecht, F.: The plasminogen activator content of the arterial wall in occlusive arterial diseases. Thrombos. Diathes. haemorrh. (Stuttg.) 27, 649–654 (1972)

    CAS  Google Scholar 

  • Correli, J. T., Sjoerdsma, A.: Inhibition of a human fibrinolytic system by normal and pathologic serums. Proc. Soc. exp. Biol. (N.Y.) 111, 274–277 (1962)

    Google Scholar 

  • Csefkó, I., Gerendás, M., Udvardy, M. D. F.: Histamine and the coagulation of blood. Orvosi Hetilap. 89, 247–250 (1948)

    Google Scholar 

  • Cunliffe, W. J.: An association between cutaneous vasculitis and decreased blood fibrinolytic activity. Lancet 1968I, 1126–1128

    Google Scholar 

  • David, G., Kenedi, I.: Experimental pulmonary embolism after pharmacological heart denervation in the rat. Acta physiol. 40, 101–106 (1971)

    CAS  Google Scholar 

  • Davidson, J. F., Conkie, J. A., McDonald, G. A.: Fibrinolytic enhancement with Stanozolol in men with ischaemic heart disease. IIIth Congress International Society on Thrombosis and Haemostasis Washington (August, 1972) Abstract p. 282 (1972 a)

    Google Scholar 

  • Davidson, J. F., Lochhead, M., McDonald, G. A., McNicol, G. P.: Fibrinolytic enhancement by Stanozolol A double blind trial. Brit. J. Haemat. 22, 543–559 (1972b)

    Article  PubMed  CAS  Google Scholar 

  • Davidson, J. F., McDonald, G. A., Conkie, J. A.: Stanozolol as a fibrinolytic agent in men with ischaemic heart disease. A thirty-month study. In: Kaulla, K. N. von, Davidson, J. F. (Eds.): Synthetic Fibrinolytic Thrombolytic Agents, pp. 328–337. Springfield: C. Thomas 1975

    Google Scholar 

  • Delaney, T. J., Black, M. M.: Effect of fibrinolytic treatment in malignant atrophic papulosis. Brit. med. J. 1975III, 5980: 415

    Google Scholar 

  • De Nicola, P.: Long-term activation of fibrinolysis in the prophylaxis of thromboembolism. In: Kaulla, K. N. von, Davidson, J. F. (Eds.): Synthetic Fibrinolytic Agents, pp.343–356. Springfield/III.: Thomas 1975

    Google Scholar 

  • De Nicola, P., Cultrera, G., Manai, G.: Fibrinogen turnover in the aged subjects following the administration of drugs acting on fibrinolysis. Farmaco, Ed. sci. 23, 10: 994–998 (1968)

    Google Scholar 

  • De Nicola, P., Gibelli, A., Frandoli, G.: Recherches cliniques et expérimentales sur le traitement fibrinolytique prolongé. Activation de la fibrinolyse par l’administration prolongée d’un inhibiteur de la mono-amine-oxydase. Hémostase 5, 11–16 (1965 b)

    Google Scholar 

  • De Nicola, P., Gibelli, A., Turazza, G., Nadile, L.: Untersuchungen über die fibrinolytische Wirkung eines Heparinkörpers beim Menschen. Arzneimittel-Forsch. 15, 1430–1433 (1965 a)

    Google Scholar 

  • Denk, H., Fischer, M.: Histochemische Untersuchungen der fibrinolytischen Aktivität an experimentell erzeugten Thromben bei Ratten nach Gabe von direkten und indirekten Fibrinolytika. Thrombos. Diathes. haemorrh. (Stuttg.) 24, 48–54 (1970)

    CAS  Google Scholar 

  • Desnoyers, P., Anstett, M., Labaume, J., Schmitt, H.: Effect of α- and β-adrenoceptor stimulating and blocking agents on fibrinolytic activity in rats. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 1, pp. 367–374. New York: Raven 1975 b

    Google Scholar 

  • Desnoyers, P., Duhault, J., Beregi, L., Hugon, P.: Effect of new sulfonylureas on different parameters of haemostasis. Diabetologia 6, 43 (1970)

    Google Scholar 

  • Desnoyers, P., Labaume, J., Anstett, M., Baudet, M., Cure, R., Herrera, M., Pesquet, J., Sebastien, J., Samama, M.: Pharmacological screening of synthetic fibrinolytic-thrombolytic agents: comparison between synthetic and enzymatic compounds. In: Kaulla, K. N. von, Davidson, J. F. (Eds.): Synthetic Fibrinolytic Thrombolytic Agents, pp. 199–226. Springfield/III.: Thomas 1975a

    Google Scholar 

  • Desnoyers, P., Labaume, J., Anstett, M., Herrera, M., Pesquet, J., Sebastien, J.: The pharmacology of S1702, a new highly effectiv oral antidiabetic drug with unusual properties. Part 3: Anti-stickiness activity, fibrinolytic properties and haemostatic parameters study. Arzneimittel-Forsch. 22, 1691–1695 (1972b)

    CAS  Google Scholar 

  • Desnoyers, P., Labaume, J., Baudet, M., Verry, M.: Fibrinolytic activity of vascular endothelium, demonstrated by Todd’s method, after administration of a new antidiabetic drug 1702 SE. IIth Congress of the Internat. Soc. on Thrombosis and Haemostasis Oslo (12–16 July) Abstract p. 118 (1971b)

    Google Scholar 

  • Desnoyers, P., Labaume, J., Brunerie, C.: Diabetic angiopathy: large venous vessels, retinal and kidney vascular endothelium fibrinolytic activity: influence of gliclazide administration on the rat (XIIth Congrès International de Thérapeutique, Genève, 1973). Progr. méd. 7, 274 (1973)

    Google Scholar 

  • Desnoyers, P., Labaume, J., Conard, J., Samama, M.: Essai de contribution au mécanisme d’action thrombolytique de composés chimiques synthétiques. Bibl. haemat. (Basel) 38, 776–783 (1971a)

    Google Scholar 

  • Desnoyers, P., Labaume, J., Conard, J., Samama, M.: Contribution to the study of mechanism of action of synthetic thrombolytic chemical agents. (IIIth Symposium on Thrombosis-Pilsen 1970) Acta. Univ. Carol.: Med. Monographia 52, 33–40 (1972 a)

    CAS  Google Scholar 

  • Deutsch, E., Eisner, P.: Pyrogens as thrombolytic agents. Clinical and experimental studies. Amer. J. Cardiol. 6, 420–424 (1960)

    Article  PubMed  CAS  Google Scholar 

  • Dohn, K., Hvidt, V., Nielsen, J., Palm, L.: Testosterone therapy in obliterating arterial lesions in the lower limbs. Angiology 19, 342–350 (1968)

    Article  PubMed  CAS  Google Scholar 

  • Donner, L.: Einfluß der Dicumarolpräparate auf die Fibrinolyse. Schweiz. med. Wschr. 90, 1254–1255 (1960)

    PubMed  CAS  Google Scholar 

  • Donner, L., Bracová, S., Setkova, O.: The effect of Pelentan (Ethylum dihydroxy-cumarinylaceticum) on fibrinolysis. Blood 18, 116 (1961)

    Google Scholar 

  • Eichenberger, E.: Fibrinolyse nach intravenöser Injektion bakterieller Pyrogene. Acta Neuroveget. 11, 201–209 (1955)

    Article  CAS  Google Scholar 

  • Endo, K.: Blood fibrinolytic activity in diabetics before and after treatment. J. Jap. Soc. int. Med. 59, 16 (1970)

    Article  CAS  Google Scholar 

  • Fanciullacci, M., Sicuteri, F., Giotti, A., Brunetti, S.: La Taurina come agente fibrinolitico nell’ uomo: Prime osservazioni terapeutiche. Clin. Ter. 53, 3–8 (1970)

    PubMed  CAS  Google Scholar 

  • Fearnley,G. R.: Proc. 2nd ACTH Conference, New York, Vol. 2. 1951, p. 561

    Google Scholar 

  • Fearnley, G. R.: Pharmacological enhancement of fibrinolytic activity of blood. J. clin. Path. 17, 328–333 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Fearnley, G. R.: The pharmacology of fibrinolysis. Fibrinolysis. London: Arnold 1965

    Google Scholar 

  • Fearnley, G. R.: Fibrinolysis and fibrinolytic drugs. Practitioner 196, 585–592 (1966)

    PubMed  CAS  Google Scholar 

  • Fearnley, G. R.: Phenformin and Stanozolol in blood fibrinolytic activity. Brit. med. J. 1970I, 693 (1970a)

    Google Scholar 

  • Fearnley, G. R.: Pharmacological enhancement of fibrinolysis. In: Schor, J. M. (Ed.): Chemical Control of Fibrinolysis-Thrombolysis, pp.205–243. New York-London-Sydney-Toronto: Wiley-Interscience 1970 b

    Google Scholar 

  • Fearnley, G. R.: Ethyloestrenol and postoperative venous thrombosis. Lancet 1973II, 95

    Google Scholar 

  • Fearnley, G. R.: Development of oral fibrinolytic therapy. In: Kaulla, K. N. von, Davidson, J. F. (Eds.): Synthetic Fibrinolytic Thrombolytic Agents, pp.305–311. Springfield/III.: Thomas 1975

    Google Scholar 

  • Fearnley, G. R., Bunim, J. J.: Effect of adrenocorticotropic hormone (ACTH) on the erythrocyte-sedimentation rate and plasma-fibrinogen and serum-protein levels in normal persons. Lancet 1951II, 1113–1116

    Google Scholar 

  • Fearnley, G. R., Chakrabarti, R.: Increase of blood fibrinolytic activity by testosterone. Lancet 1962II, 128–132

    Google Scholar 

  • Fearnley, G. R., Chakrabarti, R.: Effect of ethyloestrenol combined with phenformin or with metformin on platelet stickiness and serum-cholesterol in patients with occlusive vascular disease. Lancet 1968II, 1004–1007

    Google Scholar 

  • Fearnley, G. R., Chakrabarti, R.: Mode of action of phenformin plus éthyloestrenol on fibrinolysis. Lancet 1971I, 723–725

    Google Scholar 

  • Fearnley, G. R., Chakrabarti, R., Evans, J. F.: The pharmacological enhancement of blood fibrinolytic activity with special reference to phenformin. Acta cardiol. (Brux.) 19, 1–13 (1964)

    CAS  Google Scholar 

  • Fearnley, G. R., Chakrabarti, R., Evans, J. F.: Fibrinolytic and defibrinating effect of phenformin plus ethyloestrenol in vivo. Lancet 1969I, 910–914

    Google Scholar 

  • Fearnley, G. R., Chakrabarti, R., Hocking, E. D.: Phenformin in rheumatoid arthritis. A fibrinolytic approach. Lancet 1965I, 9–13

    Google Scholar 

  • Fearnley, G. R., Chakrabarti, R., Hocking, E. D., Evans, J.: Fibrinolytic effects of biguanides plus ethyloestrenol in occlusive vascular disease. Lancet 1967II, 1008–1011

    Google Scholar 

  • Fearnley, G. R., Chakrabarti, R., Vincent, C. T.: Effect of the sulphonylureas on fibrinolysis. Lancet 1960II, 622–625

    Google Scholar 

  • Fearnley, G. R., Ferguson, J.: Presence of fibrinolytic activity in whole blood, masked by the clotting process. Clin. Sci. 17, 555–561 (1958)

    PubMed  CAS  Google Scholar 

  • Fearnley, G. R., Vincent, C. T., Chakrabarti, R.: Reduction of blood fibrinolytic activity in diabetes mellitus by insulin. Lancet 1959II, 1067

    Google Scholar 

  • Fiaschi, E., Barbui, T., Previato, G., Di Luzio, V., Guarnieri, G. F., Todesco, S.: The effects of phenformin on blood fibrinolysis in diabetes mellitus. Arzneimittel-Forsch. 19, 638–640 (1969)

    CAS  Google Scholar 

  • Fitzgerald, D. E., Szeto, I. L. F., Spero, J., Lewis, J. H.: The thrombolytic effect of heparin and a heparin-like substance, SP 54. Thrombos. Diathes. haemorrh. (Stuttg.) 17, 418–422 (1967)

    CAS  Google Scholar 

  • Fletcher, A. P.: Pathological fibrinolysis. Fed. Proc. 25, 84–88 (1966)

    PubMed  CAS  Google Scholar 

  • Fossard, D. P., Friend, I. R., Field, E. S., Corrigan, T. P., Kakkar, V. V., Flute, P. T.: Fibrinolytic activity and postoperative deep-vein thrombosis. Lancet 1974I, 9–11

    Google Scholar 

  • Frandoli, G., Gibelli, A., Giarola, P. A., De Nicola, P.: Untersuchungen über die prolongierte Aktivierung der Fibrinolyse. Arzneimittel-Forsch. 17, 1397–1400 (1967)

    CAS  Google Scholar 

  • Frandoli, G., Spreafico, P. L., Lampugnani, P., Tammaro, A.E.: Action on fibrinolysis and platelet aggregation of a synthetic, heparin-like sulfated polyanion (SP 54) given orally and parenteraly, as related to lipidic fractions. Arzneimittel-Forsch. 22, 759–763 (1972)

    CAS  Google Scholar 

  • Gader, A. M. A., Da Costa, J., Cash, J. D.: A new vasopressin analogue and fibrinolysis. Lancet 1973II, 1417–1418

    Google Scholar 

  • Genster, H. G., Oram, V.: Arterial insufficiens i underekstremiteterne behandlet medikamentelt. Ugeskr. Laeg. 6, 244–246 (1971)

    Google Scholar 

  • Genton, E., Kern, F., von Kaulla, K. N.: Fibrinolysis induced by pressor amines. Amer. J. Med. 31, 564–571 (1961)

    Article  PubMed  CAS  Google Scholar 

  • Gerendás, M., Csefkó, I., Udvardy, M. D. F.: Histamine-heparin-thrombin chain mechanism. Nature (Lond.) 162, 257–258 (1948)

    Article  Google Scholar 

  • Ghanem, M. H., Guirgis, F. K., El Sawy, M.: Effect of buformin on fibrinolytic activity in rheumatoid arthritis. Arzneimittel-Forsch. 22, 1487–1489 (1972)

    CAS  Google Scholar 

  • Giarola, P., Egge, H., Gibelli, A., Mueller, J.: β-Pyridylcarbinol in experimental hypercholesterinemia of the rabbit. Study of lipidic fractions and of the mechanisms of hemostasis. Farmaco, Ed. sci. 27, 1018–1023 (1972)

    CAS  Google Scholar 

  • Giarola, P., Egge, H., Gibelli, A., Murawski, U.: Die Wirkung eines Blutextraktes auf Plasmali-pide, Blutgerinnung, Fibrinolyse und Plättchenaggregation bei der experimentellen Hyper-cholesterinämie des Kaninchens. Arzneimittel-Forsch. 24, 925–928 (1974)

    CAS  Google Scholar 

  • Gibelli, A., Turazza, G., Giarola, P., De Nicola, P.: Action of ε-aminocaproic acid and of parotid inhibitor on the fibrinolysis activation due to nicotinic acid derivatives and to heparin-like substances. Farmaco, Ed. sci. 21, 301–309 (1966)

    CAS  Google Scholar 

  • Goodhart, J. M., Dewar, H. A.: Effect of atromid-S on fibrinolytic activity in patients with ischemic heart disease and normal blood cholesterol levels. Brit. med. J. 1966I, 325–327

    Google Scholar 

  • Goossens, N.: Ãœber Fibrinolyseaktivierung in vitro und in vivo durch Nikotinsäure, Heparin und deren Mischungen. Med. Welt (Stuttg.) 14, 899–903 (1967)

    CAS  Google Scholar 

  • Grishin, A. I.: Dexametazone and aldosterone action on the blood coagulation system. Farmakol. Toksikol 35, 90–92 (1972)

    CAS  Google Scholar 

  • Gryglewski, R. J., Eckstein, M.: Fibrinolytic activity of some biarylcarboxylic acids. Nature (Lond.) 214, 626 (1967)

    Article  CAS  Google Scholar 

  • Gryglewski, R. J., Gryglewska, T. A.: The fibrinolytic activity of N-arylanthranilates. Biochem. Pharmacol. 15, 1171–1175 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Guidi, G., Lombardi, V., Torsellini, A.: Azione di un eparinoide estrattivo su alcuni indici della coagulazione del sangue. Minerva Med. 60 (Suppl. 99) 5034–5038 (1969)

    PubMed  CAS  Google Scholar 

  • Halse, T.: Aktivierung der Fibrinolyse und Thrombolyse durch Polysaccharidschwefelsäureester (Heparinoids). Arzneimittel-Forsch. 12, 574–582 (1962)

    CAS  Google Scholar 

  • Halse, T.: Polyelectrolytes as activators of fibrinolysis and thrombolysis. Sangre 9, 149–152 (1964)

    Google Scholar 

  • Harada, M., Takeuchi, M.: Effect of histamine on clot lysis by streptokinase in vitro. Shionogi Kenhyusho Nempo 14, 207–209 (1964)

    Google Scholar 

  • Hartmann, E., Weiss, I.: The effect of alkaloids upon blood coagulation. Klin. Wschr. 9, 347–349 (1930)

    Article  CAS  Google Scholar 

  • Hedner, U., Nilsson, I. M., Isacson, S.: Effect of ethyloestrenol on fibrinolysis in the vessel wall. Thrombos. Diathes. haemorrh. (Stuttg.) 34 609 (1975)

    CAS  Google Scholar 

  • Hedner, U., Nilsson, I. M., Isacson, S.: Effect of ethyloestrenol on fibrinolysis in the vessel wall. Brit. med. J. 1976II, 729–731

    Google Scholar 

  • Heikinheimo, R.: Metformin and fibrinolysis. Scand. J. Haematol. 6, 288–290 (1969)

    Article  PubMed  CAS  Google Scholar 

  • Hellmann, K., Hawkins, R. I.: The action of tick extracts on blood coagulation and fibrinolysis. Thrombos. Diathes. haemorrh. (Stuttg.) 34, 609 (1975)

    Google Scholar 

  • Hengstmann, H., Klien, D., Becker, M.: Behavior of factors V and VII in arterial and venous blood in the pyrogen reaction. Dtsch. Arch. klin. Med. 206, 30–44 (1959)

    PubMed  CAS  Google Scholar 

  • Hengstmann, H., Klien, D., Becker, M.: The activity of factor V and factor VII complex in human circulation following administration of histamine. Dtsch. Arch. klin. Med. 206, 459–467 (1960)

    PubMed  CAS  Google Scholar 

  • Henriques, S. B., Henriques, O. B., Levy, A.: Slow hyperfibrinogenemic action of adrenaline and related substances. Brit. J. Pharmacol. 11, 99–103 (1956)

    PubMed  CAS  Google Scholar 

  • Heutzer, E., Cort-Madsen, P.: Testosterone ved arteriel insufficiens i underekstremiteterne. Nord. Med. 76, 1307–1312 (1966)

    Google Scholar 

  • Hey, D., Nazemi, M., Beneke, G.: Experimental approach to lysis of fibrin in vivo. Z. ges. exp. Med. 153, 169–186 (1970)

    Article  CAS  Google Scholar 

  • Hocking, E. D., Chakrabarti, R., Evans, J.: Effect of biguanides and atromid on fibrinolysis. J. Atheroscler. Res. 7, 121–130 (1967)

    Article  PubMed  CAS  Google Scholar 

  • Hoerder, M. H., Wendt, F.: Fibrinolyse und Gerinnungsfaktoren nach Injektion von bakteriellen und endogenen Pyrogenen beim Menschen. (Proc. 7 th Congress of the International Society of Hematology, Rome, 1958). New York: Grune and Stratton 1960

    Google Scholar 

  • Holemans, R.: Enhancement of fibrinolysis in the dog by injection of vasoactive drugs. Amer. J. Physiol. 208, 511–520 (1965)

    PubMed  CAS  Google Scholar 

  • Holemans, R., Langdell, R. D.: Histamine-induced increase in fibrinolytic activity. Proc. Soc. exp. Biol. (N.Y.) 115, 584–587 (1964)

    CAS  Google Scholar 

  • Ingram, G. I. C., Vaughan-Jones, R.: Alterations of fibrinolysis and blood coagulation. Lancet 1969I, 310

    Google Scholar 

  • Isacson, S.: Low fibrinolytic activity of blood and vein walls in venous thrombosis. Scand. J. Haematol. (Suppl. 16) 1–29 (1971)

    CAS  Google Scholar 

  • Isacson, S., Nilsson, I. M.: Antithrombotic effect of a combined phenformin-ethyloestrenol medication. In: Kaulla, K. N. von, Davidson, J. F. (Eds.): Synthetic Fibrinolytic Thrombolytic Agents, pp. 312–316. Springfield: Thomas 1975

    Google Scholar 

  • Ivleva, A. Y.: Changes in blood fibrinolytic activity following the intravenous injection of aminoglycoside antibiotics. Farmakol. Toksikol. 32, 321–324 (1969)

    PubMed  CAS  Google Scholar 

  • Ivleva, A. Y., Zolotukhin, S. I.: Thrombolytic means of non-enzymic character: Review of the literature. Farmakol. Toksikol. 36, 359–365 (1973)

    PubMed  CAS  Google Scholar 

  • Izhizu, H., Nobuhara, M.: Fluidity of blood studied on the basis of fibrinolysis. VII: Fibrinolytic activity and blood catecholamine level after the administration of cholinergic stimulants. Nippon Hoigaku Zasshi 24, 455–461 (1970)

    Google Scholar 

  • Jarrett, P. E. M., Burnand, K. G., Morland, M., Browse, N. L.: The treatment of venous liposclero-sis of the legs by fibrinolytic enhancement. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 3. New York: Raven 1978a

    Google Scholar 

  • Jarrett, P. E. M., Morland, M., Browse, N. L.: The fibrinolytic activity and treatment by stanozolol of patients with idiopathic recurrent superficial thrombophlebitis. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 3. New York: Raven 1978b

    Google Scholar 

  • Jarrett, P. E. M., Morland, M., Browse, N. L.: The effect of oxpentifylline (Trental) on fibrinolytic activity and plasma fibrinogen levels. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 3. New York: Raven 1978c

    Google Scholar 

  • Jürgens, J.: The hemostyptic effect of histamine and its relation to the function of the stomach. Z. ges. inn. Med. 3, 272–281 (1948)

    PubMed  Google Scholar 

  • Katalin, M., Jozsef, S.: A Fibrinolizis es Gyogyszertana. Gyogyszereszet 11, 97–100 (1967)

    Google Scholar 

  • Kaulla, K. N. von: Intravenous protein-free pyrogen: a powerful fibrinolytic agent in man. Circulation 17, 187–198 (1958)

    Google Scholar 

  • Kaulla, K. N. von: Experimental and clinical approaches toward thrombolysis by mobilizing the body’s own fibrinolytic system. In: Chemistry of Thrombolysis: Human fibrinolytic enzymes, pp.240–260. Springfield, III.: Thomas 1963

    Google Scholar 

  • Kaulla, K. N. von: A simple test tube arrangement for screening fibrinolytic activity of synthetic organic compounds. J. med. Chem. 8, 164–166 (1965)

    Article  Google Scholar 

  • Kaulla, K. N. von: Structure-dependent fibrinolytic (clot-dissolving) activity of anti-inflammatory drugs and related compounds. Abstr. Papers. Amer. chem. Soc. 153, 1 M (1967)

    Google Scholar 

  • Kaulla, K. N. von: On an in-vitro mechanism of action of synthetic fibrinolytic agents. Abstr. Papers, Amer. chem. Soc. 155, 21 N (1968)

    Google Scholar 

  • Kaulla, K. N. von, MacDonald, T. S.: The effect of heparin on the components of the human fibrinolytic system. Blood 13, 811–821 (1958)

    Google Scholar 

  • Kaulla, K. N. von, Smith, R. L.: Urea derivatives as fibrinolysis promoting agents. Proc. Soc. Exptl. Biol. Med. 106, 530–533 (1961)

    Google Scholar 

  • Kirschninck, H.: Ãœber einige Inhaltsstoffe von Florideen und ihre Wirkungsrichtungen. Arzneimittel-Forsch. 15, 947–948 (1965)

    CAS  Google Scholar 

  • Kiseleva, L. N., Romanenko, G. K.: Changes of the blood coagulation and anticoagulation systems under the influence of nicotinic acid. Klin. Med. 44, 48–50 (1966)

    CAS  Google Scholar 

  • Koestering, H., Koenig, F., Weber, S., Warmann, E., Guerrero, M.: Einfluß von oral und transkutan appliziertem SP 54 auf präformierte Thromben im Tierversuch. Med. Welt (Stuttg.) 24, 139–140 (1973)

    CAS  Google Scholar 

  • Kokot, F.: Effect of serotonin and 5-hydroxyindoleacetic acid on plasma clearing and fibrinolysis. Patol. Polska 12, 321–325 (1961)

    CAS  Google Scholar 

  • Kokot, F.: Effect of serotonin on the behavior of euglobulin and serum fibrinolysis and on the blood fibrinogen level in experimental atherosclerosis in pigeons. Patol. Polska 13, 177–183 (1962)

    CAS  Google Scholar 

  • Kopper, P. H.: Rapid induction of in vivo fibrinolysis with D-gluconyl-l-tyrosine. Nature (Lond.) 211, 1417 (1966)

    Article  CAS  Google Scholar 

  • Kovacs, I. B., Csalay, L., Csakvary, G.: Antithrombotic and fibrinolytic effect of bencyclane. Arzneimittel-Forsch. 21, 1553–1556 (1971)

    CAS  Google Scholar 

  • Kraft, E.: The treatment of thromboembolism with drugs which activate endogenous fibrinolysis. Dtsch. med. Mschr. 8, 63–66 (1963)

    Google Scholar 

  • Kroll, J.: Influence of bile salts on the lysis of I131-labelled plasma clots in human subcutaneous tissue in vivo. Scand. J. clin. Lab. Invest. 18, 691–692 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Kudryashov, B. A., Lyapina, L. A.: Heparin-adrenaline complex as a humoral agent of the blood anticoagulating system. Vopr. Med. Khim. 17, 46–53 (1971)

    CAS  Google Scholar 

  • Kudryashov, B. A., Lyapina, L. A.: The heparin-urea complex, its physico-chemical properties. Vopr. Med. Khim. 21, 165–168 (1975)

    CAS  Google Scholar 

  • Kudryashov, B. A., Lyapina, L. A., Moltchanova, L. V., Rustamova, B. A.: On the nature of lytic effect of fibrinogen-heparin and thyroxin heparin complexes on fibrin. Vopr. Med. Khim. 16, 161–168 (1970)

    CAS  Google Scholar 

  • Kudryashov, B. A., Lyapina, L. A., Zhitnikova, E. S., Obraztsov, V. V.: Formation of the secondary complex of adrenaline-heparin-fibrinogen and its properties. Vopr. Med. Khim. 21, 65–69 (1975 a)

    CAS  Google Scholar 

  • Kudryashov, B. A., Pastorova, V. E., Lyapina, L. A.: The effect of low doses of heparin-urea complex on the aggregation of thrombocytes and fibrinolytic activity of the blood with i. v. injections and in vitro tests. Farmakol. Toksikol. 38, 441–444 (1975 b)

    CAS  Google Scholar 

  • Kumada, T., Abiko, Y.: Enhancement of fibrinolytic and thrombolytic potential in the rat by treatment with an anabolic steroid, furazabol. Thrombos. Haemostas. 36, 451–464 (1976)

    CAS  Google Scholar 

  • Kuznik, B. I., Basov, V. I., Tsybikov, N. N.: Mechanism of histamine action on the blood coagulability. Farmakol. Toksikol. 35, 448–452 (1972)

    PubMed  CAS  Google Scholar 

  • Kwaan, H. C., Brakman, P., Astrup, T.: Enhancement of fibrinolysis and thrombolysis by polysorbate 80 (Tween 80). Experientia (Basel) 23, 261–262 (1967)

    Article  CAS  Google Scholar 

  • Kwaan, H. C., Lo, R., McFadzean, A. J. S.: On lysis of thrombi experimentally produced within veins. Brit. J. Haemat. 4, 51 (1958)

    Article  PubMed  CAS  Google Scholar 

  • Lassman, H. B., Back, N.: Biochemical pharmacology of the fibrinolysin system of the rat. II: The effect of insulin-induced hypoglycemia. J. Pharmacol. exp. Ther. 189, 327–332 (1974a)

    PubMed  CAS  Google Scholar 

  • Lassman, H. B., Back, N.: Biochemical pharmacology of the fibrinolysin system of the rat. III: The mechanism of phenformin (1-(β-phenethyl)-biguanide)-induced fibrinolytic activity. J. Pharmacol. exp. Ther. 189, 333–343 (1974b)

    PubMed  CAS  Google Scholar 

  • Lassman, H. B., Wilkens, H., Back, N.: Biochemical pharmacology of the fibrinolysin system of the rat. I: The effect of alloxan-induced hyperglycemia. J. Pharmacol. exp. Ther. 189, 317–326 (1974)

    PubMed  CAS  Google Scholar 

  • Lazar, G., Toth, A., Karady, I.: Effect of adaptation to histamine and epinephrine on hyperfibri-nogenemia induced by histamine and epinephrine. Acta physiol. 41, 107–112 (1972)

    CAS  Google Scholar 

  • Löfgren, L.: The tissue mast cells, blood-clotting time, and changes in the relative proportions of the white blood cells of guinea pigs during histamine treatment. Acta anat. 26, 62–80 (1956)

    Article  PubMed  Google Scholar 

  • MacNicol, G. P., Douglas, A. S.: Urokinase and non-enzymatic fibrinolytic agents. Scand. J. clin. Lab. Invest. 16 (Suppl. 78), 34–36 (1964)

    Google Scholar 

  • Magda, K., Szegi, J.: Anti-thrombic effect of monoaminooxidase blocking agents. Gyogyszer-eszet. 14, 135–141 (1970)

    CAS  Google Scholar 

  • Mannucci, P. M.: Mechanism of plasminogen activator and factor VIII rise induced by vasoactive drugs. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 1, pp. 109–110. New York: Raven 1975

    Google Scholar 

  • Mannucci, P. M., Pared, F. I., Barbi, G. L.: Effect of cyclic AMP and related drugs on plasminogen activator. In: Kaulla, K. N. von and Davidson, J. F. (Eds.): Synthetic Fibrinolytic Thrombolytic Agents. Springfield, III.: Thomas 1975

    Google Scholar 

  • Markwardt, F.: Biochemisch-pharmakologische Grundlagen der antithrombotischen Therapie. Folia haemat. (Lpz.) 103, 293–312 (1976)

    CAS  Google Scholar 

  • Markwardt, F., Klöcking, H.-P.: Studies on the release of plasminogen activator. Thrombos. Res. 8, 217–223 (1976)

    Article  CAS  Google Scholar 

  • Markwardt, F., Klöcking, H.-P.: Heparin-induced release of plasminogen activator. Haemostasis 6, 370–374 (1977)

    PubMed  CAS  Google Scholar 

  • Meneghini, P.: La shock-vaccino terapia nella cura di un caso di thrombosi traumatica della vena cava inf. Arch. E. Maragliano Pat. Clin. 4, 771–777 (1949)

    CAS  Google Scholar 

  • Meneghini, P.: Fibrinolytic treatment of thrombo-embolic disease with purified bacterial pyrogens. Acta haemat. (Basel) 19, 65–81 (1958)

    Article  CAS  Google Scholar 

  • Meneghini, P.: The development of thrombolytic activity. Thrombos. Diathes. haemorrh. (Stuttg.) 6 (Suppl. 1) 217–226 (1961)

    Google Scholar 

  • Meneghini, P., Morando, G. D.: L’insufficienza venosa post-trombotica. Osservazioni a distanza sul trattamento fibrinolitico-anticoagulante. Minerva Med. 52 2835–2839 (1961)

    PubMed  CAS  Google Scholar 

  • Meneghini, P., Piccinini, F.: Attivazione fibrinolytica del sangue da acido da alcool nicotinico. Arch. E. Maragliano Pat. Clin. 14, 69–74 (1958)

    CAS  Google Scholar 

  • Menon, I. S., Cunliffe, W. J., Weightman, D., Dewar, H. A.: Phenformin and stanozolol in blood fibrinolytic activity. Brit. med. J. 1970I, 428

    Google Scholar 

  • Menon, I. S., Kendal, R. Y., Dewar, H. A., Newell, D. J.: Effect of onions on blood fibrinolytic activity. Brit. med. J. 1968II, 351–352

    Google Scholar 

  • Milne, W. L., Cohn, S., Pate, R. D.: Role of serotonin in blood coagulation. Amer. J. Physiol. 189, 470–474 (1957)

    PubMed  CAS  Google Scholar 

  • Mischenko, V. P., Kuznik, B. I., Bochkarnikov, V. V.: Mechanism of action of vasoactive agents on blood clotting and fibrinolysis. Cor Vasa 14, 228–238 (1972)

    Google Scholar 

  • Moschos, C. B., Lehan, P. H., Oldewurtel, H. A., Koroxenidis, G. T.: Studies of clotting and fibrinolysis across the heart: Response to catecholamines infusion. Circulation 32 (Suppl. II) 155 (1965)

    Google Scholar 

  • Muratova, J., Dlabac, A., Tricka, V., Nemecek, O.: La trimethazone, nouveau dérivé pyrazolidini-que doué d’action anti-inflammatoire et antithrombotique. Thérapie 22, 1265–1272 (1967)

    PubMed  CAS  Google Scholar 

  • Neri, S., Rossi, G. G., Rossi, F. P. I., Paoletti, P., Panti, A., D’Ayala, V. G.: Effects of bradykinin on coagulation and fibrinolysis. Study in vitro and in vivo. Thrombos. Diathes. haemorrh. (Stuttg.) 14, 508–518 (1965)

    Google Scholar 

  • Niewiarowska, M., Wegrzynowicz, Z.: Influence of dicoumarol derivatives on plasma fibrinolytic system. Thrombos. Diathes. haemorrh. (Stuttg.) 3, 279–285 (1959)

    CAS  Google Scholar 

  • Nilsson, I. M.: Agents stimulating endogenous activators of fibrinolysis: Haemorrhagic and thrombotic diseases. London-New York-Sydney-Toronto: Wiley 1974

    Google Scholar 

  • Nilsson, I. M.: Phenformin and ethyloestrenol in recurrent venous thrombosis. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 1, pp. 1–12. New York: Raven 1975

    Google Scholar 

  • Nilsson, I. M., Isacson, S.: Effect of treatment with combined phenformin and ethyloestrenol on the coagulation and fibrinolytic system. J. clin. Pathol. 25, 638–639 (1972)

    Article  PubMed  CAS  Google Scholar 

  • Nilsson, I. M., Robertson, B.: Effect of venous occlusion on coagulation and fibrinolytic components in normal subjects. Thrombos. Diathes. haemorrh. (Stuttg.) 20, 397–408 (1968)

    CAS  Google Scholar 

  • Nityanand, S., Zaidi, S. H.: Experimental pulmonary embolism and arteriosclerosis. Effect of vasospasm. Amer. Heart J. 67, 529–538 (1964)

    Article  CAS  Google Scholar 

  • Ogston, D.: The effect of phenindione on plasma fibrinolytic activity. Scot. med. J. 6, 565–566 (1961)

    PubMed  CAS  Google Scholar 

  • Ohta, G., Takegoshi, T., Ueno, K., Shimizu, M.: Synthesis of androstano (2,3-C) furazans and related compounds. Chem. pharmaceut. Bull. 13, 1445–1459 (1965)

    CAS  Google Scholar 

  • Olesen, E. S.: A fibrinolytic system in human plasma activated by peptone or acid mucopolysaccharides. Scand. J. clin. Lab. Invest. 13, 410–415 (1961)

    Article  PubMed  CAS  Google Scholar 

  • Orlikov, G. A.: Changes in coagulability, heparin level, and fibrinolytic activity of blood during the subcutaneous administration of histamine. Latv. PSR Zinat. Akad. Vestis 6, 130–133 (1969)

    Google Scholar 

  • Park, J. K., Lee, P. H.: Effects of lymph and histamine administration on blood coagulation. Proc. Intern. Congr. Hematol. 8 th, Tokyo 3, 1830–1831 (1960)

    Google Scholar 

  • Paton, W. D. M.: Histamine release by compounds of simple chemical structure. Pharmacol. Rev. 9, 269 (1957)

    PubMed  CAS  Google Scholar 

  • Payling Wright, H., Kubik, M. M., Hayden, M.: Recanalization of thrombosed arteries under anticoagulant treatment. Brit. med. 1953I,1021–1023

    Google Scholar 

  • Ponari, O., Civardi, E., Megha, A., Pini, M., Poti, R., Dettori, A. G.: Effect of alpha and beta blocking drugs on the clotting and fibrinolytic response to venous stasis in man. Brit. J. Haemat. 24,463–470 (1973)

    Article  PubMed  CAS  Google Scholar 

  • Postnov, Y. V., Ananchenko, V. G., Ulitina, P. D.: Effect of disturbances of vascular and connective tissue permeability induced by histamine on some indexes of the physiological blood anticoagulation system under experimental conditions. Arkh. Patol. 26, 31–38 (1964)

    PubMed  CAS  Google Scholar 

  • Prino, G., Mantovani, M.: Aspetti farmacologici dell’attivita fibrinolitica dell’Atéroid. Minerva Med. 60 (Suppl. 99), 5015–5022 (1969)

    PubMed  CAS  Google Scholar 

  • Prino, G., Mantovani, M., Butti, A.: Attivazione della lisi euglobulinica indotta dall’ateroid. Boll. Soc. ital. Biol. sper. 45, 133–137 (1969)

    PubMed  CAS  Google Scholar 

  • Rahn, B., Kaulla, K. N. von: Pharmacological induction of fibrinolytic activity in the dog. Proc. Soc. exp. Biol. (N.Y.) 115, 359–362 (1964)

    CAS  Google Scholar 

  • Rahn, B., Kaulla, K. N. von: Pharmakologische tierexperimentelle Fibrinolyse. Klin. Wschr. 43, 163–169 (1965)

    Article  PubMed  CAS  Google Scholar 

  • Rasche, H., Hiemeyer, V.: Zur Frage der thrombolytischen Wirkung von Heparin und Nikotinsäure. Med. Klin. 63, 63–65 (1968)

    PubMed  CAS  Google Scholar 

  • Ray, G., Astrup, T.: Effects of some polysaccharide sulfates and some phosphates on neutral proteases and plasminogen activators. Haemostasis 2, 269–276 (1974)

    CAS  Google Scholar 

  • Raynaud, R., Brochier, M., Griguer, P., Raynaud, P.: Action d’un heparinoide de synthèse (E.S.P.) sur la coagulation. Thérapie 20, 1249–1258 (1965)

    PubMed  CAS  Google Scholar 

  • Robb, P. M., Santer, G. J., Brown, I. K.: Fibrinolytic activity and D.V.T. Lancet 1974I, 455

    Google Scholar 

  • Robertson, B.: Effect of nicotinic acid in health, in thrombotic disease and in liver cirrhosis. Acta chir. scand. 137, 643–648 (1971)

    PubMed  CAS  Google Scholar 

  • Robinson, G. A. R., Butcher, R. W., Sutherland, E. W.: Cyclic AMP and hormone action. In: Cyclic AMP. New York-London: Academic 1971

    Google Scholar 

  • Rodionov, Y. Y.: Activation of blood coagulation, caused by renin and angiotensin II. Zdra-vookhr. Beloruss. 20, 25–27 (1974)

    CAS  Google Scholar 

  • Rodionov, Y. Y., Rodionov, V. Y., Koshelapov, V. I.: Effect of renin and angiotensin on blood coagulation. Dokl. Akad. Nauk SSSR 201, 1504–1506 (1971)

    PubMed  CAS  Google Scholar 

  • Rosa, A. T., Rothschild, A. M., Rothschild, Z.: Fibrinolytic activity evoked in the plasma of the normal and adrenalectomized rat by cellulose sulphate. Brit. J. Pharmacol. 45, 470–475 (1972)

    CAS  Google Scholar 

  • Roubal, Z., Nemecek, O.: Antiinflammatory compounds exhibiting fibrinolytic activity. J. med. Chem. 9, 840–842 (1966)

    Article  PubMed  CAS  Google Scholar 

  • Rüegg, M.: Fibrinolysis-enhancing effect and histamine releasing capacity of bisobrin in rats. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 1, pp. 401–405, New York: Raven 1975

    Google Scholar 

  • Samama, M.: L’activité fibrinolytique induite par le nicotinate de theophylline. C.R. Ilè Congrès International d’Angiologie, Darmstadt, 1963

    Google Scholar 

  • Samama, M.: Oral fibrinolytic therapy. Folia haemat. (Lpz.) 103, 363–371 (1976)

    CAS  Google Scholar 

  • Sandritter, W., Bergerhof, H. D., Kroker, R.: Morphologische Untersuchungen zur Wirkung des Heparins auf experimentelle Ausscheidungsthromben. Frankfurt. Z. Path. 65, 342 (1954)

    PubMed  CAS  Google Scholar 

  • Sandritter, W., Huppert, M., Schlueter, G.: Zur Frage der Fibrinolyse an experimentellen Gerin-nungs- und Ausscheidungsthromben. Klin. Wschr. 36, 651–655 (1958)

    Article  PubMed  CAS  Google Scholar 

  • Sandritter, W., Schlueter, G., Koeppel, G.: Thrombolyse im Tierexperiment. Untersuchungen mit einem Polysaccharidsulfoester und Streptokinase. Med. Welt (Stuttg.) 51, 2732–2739 (1964)

    CAS  Google Scholar 

  • Sasaki, Y., Takeyama, S.: Inhibition of adrenaline-induced fibrinolysis by alpha-adrenergic blocking agents in the rat. Jap. J. Pharmacol. 22, (Suppl. 120) (1972)

    Google Scholar 

  • Sasaki, Y., Takeyama, S.: Inhibition of adrenaline-induced fibrinolysis by alpha-adrenergic blocking agents in the rat. Jap. J. Pharmacol. 24, 737–745 (1974)

    Article  PubMed  CAS  Google Scholar 

  • Schimpf, K., Petry, H. J., Lasch, H. G.: The effect of sympathetic and parasympathetic drugs on the human circulatory system. Dtsch. Arch. klin. Med. 205, 166–175 (1958)

    PubMed  CAS  Google Scholar 

  • Schneider, C. L., Engstrom, R. M., Miyazaki, Y.: Experimental production of massive vascular stasis stepwise. Fibrination, defibrination, acute cor pulmonale, and panhemostatic depletion. Proc. Intern. Congr. Hematol. 8 th, Tokyo 3, 1618–1644 (1960)

    Google Scholar 

  • Schor, J. M., Steinberger, V., Tutko, E., Aboulafia, S., Pachter, I. J., Jacobsen, R.: Studies with the synthetic fibrinolytic compound EN 1661. In: Schor, J. M. (Ed.): Chemical Control of Fibrinolysis-Thrombolysis, pp. 113–134. New York-London-Sydney-Toronto: Wiley Interscience 1970

    Google Scholar 

  • Sherry, S.: Hemostatic mechanism and proteolysis in shock. Fed. Proc. 20, 209–218 (1961)

    Google Scholar 

  • Sherry, S., Lindemeyer, R. I., Fletcher, A. P., Alkjaersig, N.: Studies on enhanced fibrinolytic activity in man. J. clin. Invest. 38, 810–822 (1959)

    Article  PubMed  CAS  Google Scholar 

  • Shulman, S.: The effects of certain ions and neutral molecules on the conversion of fibrinogen to fibrin. Discussions Faraday Soc. 13, 109–115 (1953)

    Article  Google Scholar 

  • Sicuteri, F., Giotti, A., Fanciullacci, M., Brunetti, S.: A sulfarated amino acid as a fibrinolytic agent. Cardiov. Res. VI World Congr. Cardiol., 285 (1970)

    Google Scholar 

  • Singh, J., Oester, Y. T.: Possible effect of nicotine on in vitro human blood coagulation time. Arch. int. Pharmacodyn. 148, 237–242 (1964a)

    PubMed  Google Scholar 

  • Singh, J., Oester, Y. T.: Nicotine antagonism with heparin. Possible mode of action on human blood coagulation time in vitro. Arch. int. Pharmacodyn. 149, 354–361 (1964b)

    PubMed  CAS  Google Scholar 

  • Soulier, J. P., Koupernik, C.: Constance de la fibrinolyse au cours du choc acetylcholinique. Sang 19, 362–369 (1948)

    CAS  Google Scholar 

  • Spampanato, N.: Valutazione dell’attivita fibrinolitica ematica in pazienti trattati con complesso mucopolisaccaridico estrattivo. Minerva Med. 60 (Suppl. 99), 5068–5076 (1969)

    Google Scholar 

  • Spreafico, P. L., Frandoli, G., Turazza, G.: Fibrinolysis and platelet aggregation in the course of treatment with a combination of p-chlorophenoxyisobutyric acid derivatives in elderly arterosclerotics. Arzneimittel-Forsch. 23, 236–239 (1973)

    CAS  Google Scholar 

  • Stamm, H.: Ãœber die pathologische Aktivierung der Blutfibrinolyse beim Menschen. Geburtsh. Frauenheilk. 24, 1034–1053 (1964)

    PubMed  CAS  Google Scholar 

  • Stüttgen, G.: Skin irritation, histamine, and blood coagulation. Dermatol. Wschr. 136, 1014–1020 (1957)

    Google Scholar 

  • Sullenberger, J. W., Anlyan, W. G., Weaver, W. T.: Serotonin in intravascular thrombosis. Surgery 46,22–29 (1959) Tanser, A. R.: Fibrinolytic response to oral glucose. Lancet 1966II, 147–148

    Google Scholar 

  • Tanser, A. R., Smellie, H.: Observations on adrenaline induced fibrinolysis in man. Clin. Sci. 26, 375–380 (1964)

    PubMed  CAS  Google Scholar 

  • Tesi, M.: Aspects of clinical methodology in fibrinolytic therapy. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 1, pp. 255–265. New York: Raven 1975

    Google Scholar 

  • Thomson, W. B., Green, J., Evans, I. L.: The effect of some physiological stimuli on fibrinolytic activity in man measured by the heparin fractionation method. J. clin. Pathol. 17, 341–344 (1964)

    Article  PubMed  CAS  Google Scholar 

  • Todd, A. S.: The histological localisation of fibrinolysin activator. J. Path. Bact. 78, 281–283 (1959)

    Article  PubMed  CAS  Google Scholar 

  • Toyoda, K., Shiokawa, Y.: Proteolytic enzyme activity. I: Effect of fatigue on fibrinolysis. Nisshin Igaku 37, 263–267 (1950)

    CAS  Google Scholar 

  • Tsapogas, M. J., Cotton, L. T., Murray, J. G.: The effects of chlorpropamide on intermittent claudication and fibrinolysis. Lancet 1962I, 1213–1215

    Google Scholar 

  • Tsitouris, G., Sandberg, H., Bellet, S., Feinberg, L. J., Schraeder, J.: Effects of serotonin on inhibition of the plasmin-plasminogen fibrinolytic system in vitro. J. Lab. clin. Med. 59, 25–39 (1962)

    PubMed  CAS  Google Scholar 

  • Tudoranu, G., Foni, I., Toporas, P., Creteanu, G., Pavelescu, C.: Chemical anticoagulating agents. Sang 21, 511–514 (1950)

    PubMed  CAS  Google Scholar 

  • Turazza, G., Gibelli, A., de Nicola, P.: Fibrinolytic action of 7-(2-hydroxy-3-(N-2-hydroxyethyl-amino)propyl)-1,3-dimethylxanthine-pyridine-3-carboxylate (xanthinol nicotinate) and of 3-pyridine acetic acid, alone and associated. Farmaco, Ed. sci. 21, 416–429 (1966)

    Google Scholar 

  • Vere, D. W., Fearnley, G. R.: Suspected interaction between phenindione and ethyloestrenol. Lancet 1968II, 281

    Google Scholar 

  • Verstraete, M.: The position of long-term stimulation of the endogenous fibrinolytic system: Present achievements and clinical perspectives. Thrombos. Diathes haemorrh. (Stuttg.) 34, 613–622 (1975)

    CAS  Google Scholar 

  • Verstraete, M., Amery, A., Maes, H., Vermylen, J.: Influence of chlorpropamide and glucose on fibrinolytic activity. J. Lab. clin. Med. 61, 926–934 (1963)

    PubMed  CAS  Google Scholar 

  • Wagner, H.: Antagonistic action of histamine and vitamin E on blood coagulation. Ärztl. Wschr. 7, 248–250 (1952)

    CAS  Google Scholar 

  • Wagner-Jauregg, T., Jahn, U., Bürlimann,W.: Fibrinolytische Antirheumatika. Vergleich von Substanzen der Flufenamsäure-Reihe mit Trifluormethyl-Analogen des Azapropazons. Arzneimittel-Forsch. 23, 911–913 (1973)

    CAS  Google Scholar 

  • Walker, I. D., Davidson, J. F.: Long-term fibrinolytic enhancement with anabolic steroid therapy. A five year study. In: Davidson, J. F., Samama, M., Desnoyers, P. (Eds.): Progress in Chemical Fibrinolysis and Thrombolysis, Vol. 3. New York: Raven 1978

    Google Scholar 

  • Walker, I. D., Davidson, J. F., Young, P., Conkie, J. A.: Plasma fibrinolytic activity following oral anabolic steroid therapy. Thrombos. Diathes. haemorrh. (Stuttg.) 34, 236–245 (1975 a)

    CAS  Google Scholar 

  • Walker, I. D., Davidson, J. F., Young, P., Conkie, J. A.: Effect of anabolic steroids on plasma antithrombin III, α 2 macroglobulin and α 1 antitrypsin levels. Thrombos. Diathes. haemorrh. (Stuttg.) 34, 106–114 (1975 b)

    CAS  Google Scholar 

  • Wasantapruek, S., Von Kaulla, K. N.: A serial microfibrinolysis test and its use in rats with liver by-pass. Thrombos. Diathes. haemorrh. (Stuttg.) 15, 284–292 (1966)

    CAS  Google Scholar 

  • Weiner, M., DeCrinis, K., Redisch, W., Steele, M. J.: Influence of some vasoactive drugs on fibrinolytic activity. Circulation 19, 845–848 (1959)

    PubMed  CAS  Google Scholar 

  • Weiner, M., Redisch, W., Steele, J. M.: Occurrence of fibrinolytic activity following administration of nicotinic acid. Proc. Soc. exp. Biol. (N.Y.) 98, 755–761 (1958)

    CAS  Google Scholar 

  • Weinland, G., Weinland, W. I.: The influence of acetylcholine and histamine on blood coagulation. Dtsch. Z. Nervenheilk. 163, 125–130 (1949)

    CAS  Google Scholar 

  • Wenzel, D. G., Singh, J.: Effect of nicotine and epinephrine on in vivo coagulation time in rabbits. J. pharm. Sci. 51, 875–878 (1962)

    Article  PubMed  CAS  Google Scholar 

  • Wilson, W., Fostiropoulos, G.: Observations on the use of nicotinic acid to induce in vivo fibrinolytic activity. Amer. J. med. Sci. 238, 591 (1959)

    Article  PubMed  CAS  Google Scholar 

  • Winther, O.: Testosteron and blood fibrinolytic activity. Lancet 1965I, 823

    Google Scholar 

  • Winther, O.: Testosteron und fibrinolytische Aktivität. Vorläufige Mitteilung. Med. Welt (Stuttg.) 21, 1180–1181 (1965 b)

    CAS  Google Scholar 

  • Yamazaki, H., Sano, T., Odakura, T., Takeuchi, K., Matsumura, T., Hosaki, S., Shimamoto, T.: Appearance of thrombogenic tendency induced by adrenaline and its prevention by adrenergic blocking agent, nialamide and pyridinolcarbamate. Thrombos. Diathes. haemorrh. (Stuttg.) 26, 251–263 (1971)

    CAS  Google Scholar 

  • Yoshizaki, T.: Effects of cholinergic drugs and their blockers on adrenaline release from rat adrenal. Biochem. Pharmacol. 24, 1401–1405 (1975)

    Article  CAS  Google Scholar 

  • Zunz, E.: The action of some hormones on the coagulation of blood. Ann. Bull. Soc. roy. Sci. Med. Nat. Bruxelles, 1–2, 1–25 (1935)

    Google Scholar 

Download references

Authors

Editor information

Editors and Affiliations

Rights and permissions

Reprints and permissions

Copyright information

© 1978 Springer-Verlag Berlin · Heidelberg

About this chapter

Cite this chapter

Desnoyers, P.C. (1978). Indirect Fibrinolytic Agents. In: Markwardt, F. (eds) Fibrinolytics and Antifibrinolytics. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 46. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66863-0_10

Download citation

  • DOI: https://doi.org/10.1007/978-3-642-66863-0_10

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66865-4

  • Online ISBN: 978-3-642-66863-0

  • eBook Packages: Springer Book Archive

Publish with us

Policies and ethics