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Spontanhypoglykämien

  • Chapter
Diabetes mellitus • B

Part of the book series: Handbuch der inneren Medizin ((INNEREN 7,volume 7 / 2 / B))

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Zusammenfassung

Die Aufrechterhaltung eines normalen Blutzuckerspiegels ist das Ergebnis außerordentlich komplexer Mechanismen, an denen viele Organe und Hormone beteiligt sind. Es ist deshalb nicht überraschend, daß häufig Abweichungen, sowohl in einem unverhältnismäßig hohen Bereich (Diabetes), als auch in einem pathologisch niedrigen Bereich (Hypoglykämie) zu finden sind. Obwohl der Diabetes verschiedene Ursachen haben kann, leidet die Mehrzahl der diabetischen Patienten doch an einem relativen oder absoluten Insulinmangel. Die Gründe für die Hypoglykämie sind viel komplexer, und viele von einander unabhängige Faktoren können die Ursache dafür Scin, wobei ein Insulinüberschuß nur einer davon ist. Da es sich bei der Hypoglykämie um ein Syndrom handelt, ist es zwingend notwendig, eine exakte Differentialdiagnose zu stellen, um eine adäquate Behandlung der zugrunde liegenden Ursache einleiten zu können. Es ist nicht ausreichend, die Diagnose „Hypoglykämie“ zu stellen und dann eine kohlenhydratreiche Diät zu verordnen.

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Literatur

  • Amatuzio, D.S., Rames, E.D., Nesbitt, S.: The practical application of the rapid intravenous glucose tolerance test in various disease states affecting glucose metabolism. J. Lab. clin. Med. 48, 714 (1956).

    PubMed  CAS  Google Scholar 

  • Aosagi, T., Summerskill, W.H.J.: Gastric secretion with ulcerogenic islet cell tumor. Importance of basal acid output. Arch, intern. Med. 117, 667 (1966).

    Google Scholar 

  • Appleyard, T.N., Losowsky, M.S.: A pancreatic tumour with carcinoid syndrome and hypoglycae- mia. Postgrad, med. J. 46, 159 (1970).

    CAS  Google Scholar 

  • Arky, R.A., Arons, D.L.: Hypoglycemia in diabetes mellitus. Med. Cl. N. Amer. 55, 919 (1971).

    CAS  Google Scholar 

  • Bachmann, K.D.: Hypoglycemias of the newborn. Mschr. Kinderheilk. 117, 230 (1969).

    PubMed  CAS  Google Scholar 

  • Bell, W.E., Samaan, N.A., Longnecker, D.S.: Hypoglycemia due to organic hyperinsulinism in infancy. Arch. Neurol. 23, 330 (1970).

    PubMed  CAS  Google Scholar 

  • Bernheim, M., Larbre, F., Francois, R., Gilly, R., Pradon, M.: Hypoglycémie mortelle par adenome des ilots de Langerhans du pancreas chez lè nouveau-né. Pediatrie 16, 631 (1961).

    Google Scholar 

  • Bingle, J.P., Storey, G.W., Winter, J.M.: Fatal self-poisoning with phenformin. Brit. med. J. 1970 III, 752.

    Google Scholar 

  • Birkinshaw, V., Jr., Gurd, M.R., Randall, S.S., Cury, A.S., Price, D.E., Wright, P.H.: Investigations in a case of murder by insulin poisoning. Brit. med. J. 2, 463 (1958).

    PubMed  CAS  Google Scholar 

  • Beicher, S.J., Levy, L.J., Zarowitz, H., Spergel, G.: Glucagon-deficiency hypoglycemia: A new syndrome. Clin. Res. 18, 355 (1970).

    Google Scholar 

  • Beyer, J., Pfeiffer, E.F.: Die spontanen Hypoglykaemien. In: Diabetes mellitus (Pfeiffer, E.F., Hrsg.), Bd. II, S. 173. J.F. Lehmanns Verlag München 1971.

    Google Scholar 

  • Beyer, J., Ditschuneit, W., Melani, F., Pfeiffer, E.F.: Die Wertigkeit verschiedener Belastungsversuche bei der Diagnose des Insulinoms. Verh. dtsch. Ges. inn. Med. 73, 1080 (1967).

    Google Scholar 

  • Beyer, J.: Die spontanen Hypoglykaemien. In: Diabetologie in Klinik und Praxis, S. 549. Stuttgart: Thieme 1974.

    Google Scholar 

  • Bower, B.F., Gordan, G.S.: Hormonal effects of nonendocrine tumors. Ann. Rev. Med. 16, 83 (1965).

    PubMed  CAS  Google Scholar 

  • Brown, H., Hargreaves, H.P., Tyler, F.H.: Islet cell adenoma of pancreas; metabolic studies on patient treated with corticotropin and cortisone. Arch, intern. Med. 89, 951 (1952).

    CAS  Google Scholar 

  • Bromberger, O., Jungner, J., Zetterström, R.: Studies in spontaneous hypoglycaemia in childhood. Failure to increase the epinephrine secretion in insulin—induced hypoglycaemia. J. Pediat. 55, 713 (1959).

    Google Scholar 

  • Brunjes, S., Hodgman, J., Nowak, J., Johns, V.: Adrenal medullary function in idiopathic spontaneous hypoglycemia of infancy and childhood. Amer. J. Med. 34, 168 (1963).

    PubMed  CAS  Google Scholar 

  • Brunschwig, A., Allen, J.G., Owens, F.M., Jr., Thornton, T.F., Jr.: Alloxan in treatment of insulin-producing islet cell carcinoma of the pancreas. J. Amer. med. Ass. 124, 212 (1944).

    Google Scholar 

  • Burton, R.A., Raskin, N.H.: Alimentary (postgastrectomy) hypoglycemia. A remediable cause of recurrent Scizures. Arch. Neurol. (Chic.) 23, 14 (1970).

    CAS  Google Scholar 

  • Buse, J., Marshall, J.N., Bradham, R., Oberman, H., Buse, M.G.: Functioning islet cell adenoma with leucine-induced hypoglycemia. Arch, intern. Med. 112, 584 (1963).

    CAS  Google Scholar 

  • Butterfield, W.J.H., Abrams, M.E., Whichelow, M.J.: The 25-G intravenous glucose tolerance test: A critical appraisal. Metabolism 20, 255 (1971).

    PubMed  CAS  Google Scholar 

  • Butterfield, W.J.H., Whichelow, M.J., Wright, P.H., Woolf, L.I.: Hypoglycaemic response to leucine in a leucine-sensitive man. Nature 188, 70 (1960).

    PubMed  CAS  Google Scholar 

  • Cahill, G.F.: Starvation in man. New Engl. J. Med. 282, 668 (1970).

    PubMed  CAS  Google Scholar 

  • Cantu, R.C., Correll, J.W., Manger, W.M.: Reassessment of central neural pathways necessary for adrenal catecholamine output in response to hypoglycemia. Proc. Soc. exp. Biol. (N.Y.) 129, 155 (1968).

    CAS  Google Scholar 

  • Carter, S.K., Broder, L., Friedman, M.: Streptozotocin and metastatic islet cell tumor. Ann. intern. Med. 74, 445 (1971).

    PubMed  CAS  Google Scholar 

  • Combs, J.T., Grunt, J.A., Brandt, I.K.: New Syndrome of neonatal hypoglycemia. New Engl. J. Med. 275, 236 (1966).

    PubMed  CAS  Google Scholar 

  • Conn, J.W., Hinerman, D.L.: Effects of alloxan upon function and structure of normal and neoplastic pancreatic islet cells in man. Amer. J. Path. 24, 429 (1948).

    PubMed  CAS  Google Scholar 

  • Conn, J.W., Seltzer, H.S.: Spontaneous hypoglycemia. Amer. J. Med. 19, 460 (1955).

    PubMed  CAS  Google Scholar 

  • Cornblath, M., Rosenthal, I.M., Reisner, S.H., Wybregt, S.H., Crane, R.K.: Hereditary fructose intolerance. New Engl. J. Med. 269, 1271 (1963).

    PubMed  CAS  Google Scholar 

  • Crain, E.L. Jr., Thorn, G.W.: Functioning pancreatic islet cell adenomas; Review of literature and presentation of two new differential tests. Medicine 28, 427 (1949).

    PubMed  Google Scholar 

  • Creutzfeldt, W., Frerichs, H.: Factitious hypoglycaemia. Germ. Med. Mth. 14, 421 (1969).

    CAS  Google Scholar 

  • Creutzfeldt, W., Wille, K., Kaup, H.: Intravenöse Belastungen mit Glucose, Insulin und Tolbutamid bei Gesunden, Diabetikern, Leberzirrhotikern und Insulomträgern. Dtsch. med. Wschr. 87, 2189 (1962).

    PubMed  CAS  Google Scholar 

  • Creutzfeldt, W., Arnold, R., Creutzfeldt, C, Deuticke, U.U., Frerichs, H., Track, M.S.: Biochemical and morphological investigations of 30 human insulinomas. Diabetologia 9, 217 (1973).

    PubMed  CAS  Google Scholar 

  • Crocker, D.W., Veith, F.J.: Mesodermal tumors associated with hypoglycemia; Review of literature and report of a case. Ann. Surg. 161, 418 (1965).

    PubMed  CAS  Google Scholar 

  • Davidson, M.B., Bozarth, W.R., Challoner, D.R., Goodner, C.J.: Phenformin hypoglycemia and lactic acidosis, report of attemoted suicide. New Engl. J. Med. 275, 886 (1966).

    PubMed  CAS  Google Scholar 

  • Delell, J., Tytgat, H., Goidsenhoven, G.E. van: Diarrhea associated with pancreatic islet cell tumors. Amer. J. dig. Dis. 9, 97 (1964).

    Google Scholar 

  • Dobson, H.L.: Attempted suicide with phenformin. Diabetes 14, 811 (1965).

    PubMed  CAS  Google Scholar 

  • Drash, A., Wolff, F.: Drug therapy in leucine-sensitive hypoglycemia. Metabolism 13, 487 (1964).

    PubMed  CAS  Google Scholar 

  • Dube, A.H.: Late postprandial hypoglycemia occurring in a man with established diabetes mellitus. New Engl. J. Med. 267, 438 (1962).

    PubMed  CAS  Google Scholar 

  • Duncan, G.G., Schless, G.L.: Massive retroperitoneal fibrosarcoma, spontaneous hypoglycemia and generalized splanchnomegaly. Metabolism 10, 200 (1961).

    Google Scholar 

  • Ernesti, M., Mitchell, M.L., Raben, M.S., Giboa, Y.: Control of hypoglycaemia with diazoxide and human growth hormone. Lancet 1965I, 628.

    Google Scholar 

  • Fajans, S.S.: Leucine-induced hypoglycemia. New Engl. J. Med. 272, 1224 (1965).

    PubMed  CAS  Google Scholar 

  • Fajans, S.S., Floyd, J.C., Jr., Knopf, R.F., Rull, J., Guntsche, E.M., Cohn, J.W.: Bentothiaddia- zine suppression of insulin release from normal and abnormal islet cell tissue in man. J. clin. Invest. 45, 481 (1966).

    PubMed  CAS  Google Scholar 

  • Fajans, S.S., Schneider, J.M., Schteingart, D.E., Conn, J.W.: The diagnostic value of sodium tolbutamide in hypoglycemic states. J. clin. Endocr. 21, 371 (1961).

    PubMed  CAS  Google Scholar 

  • Felig, P., Brown, W.V., Levine, R.A., Klatskin, G.: Glucose homeostasis in viral hepatitis. New Engl. J. Med. 283, 1436 (1970).

    PubMed  CAS  Google Scholar 

  • Field, J.B., Keen, H., Johnson, P., Herring, B.: Insulinlike activity of nonpancreatic tumors associated with hypoglycemia. J. clin. Endocr. 23, 1229 (1963).

    PubMed  CAS  Google Scholar 

  • Field, R.A.: Approaches to treatment of retinopathy by modifying pituitary function. In: On the Nature and Treatment of Diabetes ( Leibel, B.S., Wrenshall, G.W., Eds.). Amsterdam: Excerpta Medica 1965.

    Google Scholar 

  • Fisher, J., Gius, J.A., Janes, R.G.: Islet cell tumor of the pancreas with hyperinsulinism; failure of surgical and alloxan treatment. Arch. Path. 60, 628 (1955).

    CAS  Google Scholar 

  • Flanagan, G.C., Schwartz, T.B., Ryan, W.G.: Studies on patients with islet cell tumors, including the phenomenon of leucine-induced accentuation of hypoglycemia. J. clin. Endocr. 21, 401 (1961).

    PubMed  CAS  Google Scholar 

  • Floyd, J.C. Jr., Fajans, S.S., Knopf, R.F., Conn, J.W.: Plasma insulin in organic hyperinsulinism: Comparative effects of tolbutamide, leucine and glucose. J. clin. Endocr. 24, 747 (1964).

    PubMed  CAS  Google Scholar 

  • Fonkalsrud, E.W., Dilley, R.B., Longmire, W.P. Jr.: Insulin secreting tumors of the pancreas. Ann. Surg. 159, 730 (1964).

    PubMed  CAS  Google Scholar 

  • Ford, H.C., Bailey, R.E.: Tolbutamide test: A misleading response. Brit. med. J. 1965II, 343.

    Google Scholar 

  • Frantz, V.K.: Tumors of the pancreas. In: Atlas of Tumor Pathology, Sect. VII Fasc. 27–28. Washington, D.C.: Armed Forces Institute of Pathology 1959.

    Google Scholar 

  • Fraser, R.A.: Hyperinsulinism under anaesthesia in a case of islet cell tumor of the pancreas. Anesthesia in a case of islet cell tumor of the pancreas. Anaesthesia 18, 3 (1963).

    PubMed  CAS  Google Scholar 

  • Fredericks, E.J., Lazor, M.Z.: Recurrent hypoglycemia associated with acute alcoholism. Ann. intern. Med. 59, 90 (1963).

    PubMed  CAS  Google Scholar 

  • Freinkel, H., Metzger, B.E.: Oral glucose tolerance curve and hypoglycemias in the fed state. New Engl. J. Med. 280, 820 (1969).

    PubMed  CAS  Google Scholar 

  • Freinkel, N., Arky, R.A., Singer, D.L., Cohen, A.K., Bleicher, S.J., Anderson, J.B., Silbert, C.K., Foster, A.E.: Alcohol hypoglycemia. IV: Current concepts of its pathogenesis. J. clin. Invest. 42, 1112 (1963).

    PubMed  CAS  Google Scholar 

  • Freinkel, N., Bleicher, S.J.: The physiologic basis for evaluation of “fasting hypoglycemias”. Amer. J. Surg. 105, 730 (1963).

    PubMed  CAS  Google Scholar 

  • Frerichs, H., Willms, B., Kasper, H., Creutzfeldt, C., Creutzfeldt, W.: Contribution to the pathogenesis of tumor hypoglycaemia. Europ. J. clin. Invest. 1, 2 (1970).

    PubMed  CAS  Google Scholar 

  • Friedlander, E.O.: Hyperinsulinism secondary to disease of the pancreas and organs adjacent to the pancreas: A review of the world literature. Ann. intern. Med. 52, 838 (1960).

    PubMed  CAS  Google Scholar 

  • Froesch, E.R., Burgi, H., Ramscier, E.B., Bally, P., Labhart Labhart, A.: Antibody-suppressible and nonsuppressible insulin-like activities in human serum and their physiologic significance. An insulin assay with adipose tissue of increased precision and specificity. J. clin. Invest. 42, 1816 (1963).

    PubMed  CAS  Google Scholar 

  • Froesch, E.R., Wolf, H.P., Bausch, H., Prader, A., Labhart, A.: Hereditary fructose intolerance. An inborn defect of hepatic fructose-1-phosphate splitting aldolase. Amer. J. Med. 34, 151 (1963).

    PubMed  CAS  Google Scholar 

  • Froesch, R.E.: Essential fructosuria and hereditary fructose intolerance. In: The Metabolic Basis of Inherited Disease (Stanbury, J.B., Wyngaarden, J.B., Frederickson, D.S., Eds.), 2nd Ed. New York: McGraw-Hill 1966.

    Google Scholar 

  • Georas, C.S., Meissner, G.F., Dillon, J.A., Calenda, D.G.: Amelioration of diabetes mellitus after pituitary infarction. New Engl. J. Med. 263, 374 (1960).

    PubMed  CAS  Google Scholar 

  • Giard, P., Croccel, L., Leuridan, B., Bedague, J.P., Valour, M.: Intoxication volontaire par sulfamide hypoglycemiant. J. Sci. Med. Lille 83, 289 (1965).

    PubMed  CAS  Google Scholar 

  • Gittler, R.D., Zucker, G., Eisinger, R., Stoller, N.: Amelioration of diabetes mellitus by an insulinoma. New Engl. J. Med. 258, 932 (1958).

    PubMed  CAS  Google Scholar 

  • Gloor, F., Pletscher, A., Hardneier, T.: Metastasierendes Inselzelladenom des Pancreas mit 5-hydroxytryptamin- und Insulinproduktion. Schweiz, med. Wschr. 94, 1476 (1964).

    CAS  Google Scholar 

  • Goldfien, A., Zileli, M.S., Despointes, R.H., Bethune, J.E.: The effect of hypoglycemia on the adrenal secretion of epinephrine and norepinephrine in the dog. Endocrinology 62, 749 (1958).

    PubMed  CAS  Google Scholar 

  • GrPorteaber, A.L., Porte, D., Jr., Williams, R.H.: Clinical use of diazoxide and mechanism for its hyperglycemic effects. Diabetes 15, 143 (1966).

    PubMed  CAS  Google Scholar 

  • Grant, D.B., Barbor, P.R.: Islet-cell tumour causing hypoglycaemia in a newborn infant. Arch. Dis. Child. 45, 434 (1970).

    PubMed  CAS  Google Scholar 

  • Greider, M.H., Mc Guigan, J.E.: Cellular localization of gastrin in the human pancreas. Diabetes 20, 389 (1971).

    CAS  Google Scholar 

  • Grollman, A., Mc Caleb, W.E., White, F.N.: Glucagon deficiency as a cause of hypoglycemia. Metabolism 13, 686 (1964).

    PubMed  CAS  Google Scholar 

  • Grunt, J.A., Pallotta, J.H., Soeldner, J.S.: Blood sugar, serum insulin and free fatty acid interrelationships during intravenous tolbutamide testing in normal young adults and in patients with insulinoma. Diabetes 19, 122 (1970).

    PubMed  CAS  Google Scholar 

  • Gutman, R.A., Lazarus, N.R., Penhos, J.C., Fajans, S., Recant, L.: Circulating Proinsulin-like material in patients with functioning insulinomas. New Engl. J. Med. 284, 10003 (1971).

    Google Scholar 

  • Haarstad, J.: Hormone-producing insuloma in diabetes mellitus. Acta med. scand. 159, 247 (1957).

    PubMed  CAS  Google Scholar 

  • Hardy, J.D.: Islet cell tumors. Amer. J. med. Sci. 246, 218 (1963).

    PubMed  CAS  Google Scholar 

  • Harris, S.: Hyperinsulinism and dysinsulinism. J. Amer. med. Ass. 83, 729 (1924).

    Google Scholar 

  • Hartmann, A.F. Jr., Wohltmann, H.J., Holowach, J., Caldwell, B.M.: Studies in hypoglycemia. J. Pediat. 56, 211 (1960).

    PubMed  Google Scholar 

  • Hartsuck, J.M., Brooks, J.R.: Functioning beta islet cell tumors. Amer. J. Surg. 117, 541 (1969).

    PubMed  CAS  Google Scholar 

  • Hempel, H.C., Hupfer, H., Grimm, J.: Differential diagnosis and therapy of hypoglycemic Scizures in childhood. A case of pancreas beta cell hyperplasia. Mschr. Kinderheilk. 117, 90 (1969).

    PubMed  CAS  Google Scholar 

  • Hensler, L., Hartmann, H.: Diabetes mellitus, kompensiert durch Beta-Zellademon des Pancreas. Schweiz, med. Wschr. 86, 630 (1956).

    CAS  Google Scholar 

  • Hlad, C.J., Elrick, H.: Further studies of the kinetics of glucose utilization. I. A new method of data analysis. J. clin. Endocr. 14, 1258 (1959).

    Google Scholar 

  • Howard, J.M., Moss, N.H., Rhoads, J.E.: Hyperinsulinism and islet cell tumors of the pancreas. Int. Abstr. Surg. 90, 417 (1950).

    PubMed  CAS  Google Scholar 

  • Huff, T.A., Morton, E.S., Lebovitz, H.E.: Abnormal insulin secretion in myotonic dystrophy. New Engl. J. Med. 277, 837 (1967).

    PubMed  CAS  Google Scholar 

  • Huizenga, K.A., Goodrick, W.I.M., Summerskill, W.H.J.: Peptic ulcer with islet cell tumor; a reappraisal. Amer. J. Med. 37, 564 (1964).

    PubMed  CAS  Google Scholar 

  • Ingmansson, S., Lunderquist, A., Lunderquist, J., Lövdahl, R., Tibblin, S.: Portal and Pancreatic vein Catheterization with radioimmunologic Determination of insulin. Surg. Gynec. Obstet. 141, 705 (1975).

    Google Scholar 

  • Isselbacher, K.J., Greenberger, N.J.: Metabolic effects of alcohol on the liver. New Engl. J. Med. 270, 351 (1964).

    PubMed  CAS  Google Scholar 

  • Janitzki, U., Pioch, W., Schleyer, F., Ditschuneit, H., Pfeiffer, E.: Über den Insulinnachweis in der Leiche bei Insulinvergiftung. Med. Exp. 3, 17 (1960).

    PubMed  CAS  Google Scholar 

  • Johnston, R., Goetz, F.C., Zimmermann, B.: Insulin-secreting tumor of the pancreas. Report of a case with an untoward response to tolbutamide and with a study of the possible mechanism of postoperative hyperglycemia. New Engl. J. Med. 263, 1345 (1960).

    PubMed  CAS  Google Scholar 

  • Kaplan, N.M., Parker, G.W., Beering, S.G.: Hypopituitarism and diabetes mellitus: A case report with observations on metabolic interrelationships. Metabolism 10, 447 (1961).

    PubMed  CAS  Google Scholar 

  • Karsh, R.S., Freedman, H., Blumenthal, H.T.: Functional islet cell carcinoma metastasizing as spindle cell tumor. A possible clue to the riddle of extrapancreatic tumors causing hypoglycemia. Amer. J. Med. 30, 619 (1961).

    PubMed  CAS  Google Scholar 

  • Kicic, M., Milanovic, D., Palmar, I., Jelacic, O.: Serous hypoglycemia caused by a tumor of the thoracic cavity. Acta Iugosl. 20, 246 (1966).

    CAS  Google Scholar 

  • Knorr, D., Wittermann, E.: Fructose-Intoleranz und das Verhalten der unveresterten Fettsäuren (UFS) bei Fructosebelastung. Klin. Wschr. 41, 565 (1963).

    PubMed  CAS  Google Scholar 

  • Krause, U., Beyer, J., Usadel, K.H., Stelzner, F.: Different insulinproducing tumors in a patient with polyadenomatosis of the islet cells. Acta endocr. (Kbh.) Suppl. 184, 96 (1974).

    Google Scholar 

  • Krause, U., Beyer, J., Cordes, U., Happ, J.: Serum-C-Peptidspiegel und Serum-Insulin bei Patienten mit Hypoglykämien sowie unterschiedlichen Über- und Unterfunktionszuständen des Inselzellsystems. IV. Internationales Donau-Symposium über Diabetes mellitus, Dubrovnik 1975.

    Google Scholar 

  • Kreisberg, R.A., Hershman, J.M., Spenney, J.G., Bowhell, B.R., Pennington, L.F.: Biochemistry of extrapancreatic tumor hypoglycemia. Diabetes 19, 248 (1970).

    PubMed  CAS  Google Scholar 

  • Kreisberg, R.A., Pennington, L.F.: Tumor hypoglycemia, a heterogeneous disorder. Metabolism 19, 445 (1970).

    PubMed  CAS  Google Scholar 

  • Lancet Editorial: The hepatic glycogenoses. Lancet 1971I, 1339.

    Google Scholar 

  • Landau, B.R., Levine, H.J., Hertz, R.: Prolonged glucagon administration in a case of hyperinsu- linism due to disseminated islet cell carcinoma. New Engl. J. Med. 259, 286 (1958).

    PubMed  CAS  Google Scholar 

  • Landor, J.H., Klachko, D.M., Lie, T.H.: Continuous monitoring of blood glucose during operation for islet cell adenomas. Ann. Surg. 171, 394 (1970).

    PubMed  CAS  Google Scholar 

  • Laroche, G.P., Ferris, D.O., Priestley, J.T.: Hyperinsulinism: Surgical results and management of occult functioning islet cell tumor: Review of 154 cases. Arch. Surg. 96, 763 (1968).

    PubMed  CAS  Google Scholar 

  • Lazarus, N.R., Tanese, T., Gutman, R., Recant, L.: Synthesis and release of proinsulin and insulin by human insulinoma tissue. J. clin. Endocr. 30, 273 (1970).

    PubMed  CAS  Google Scholar 

  • Leger, L., Lemaigre, G.: Apropos of a series of 20 adenomas of langerhans islets. Bull. Acad. Natl. Med. (Paris) 152, 79 (1968).

    CAS  Google Scholar 

  • Levin, B., Snodgrass, J., Oberholzer, B.A.: Fructosemia, observations on seven cases. Amer. J. Med. 45, 826 (1968).

    PubMed  CAS  Google Scholar 

  • Levat, M., Tissot, A., Pasquier, J.: Cancer Langerhansien et diabete sucre. Presse Med. 73, 945 (1965).

    Google Scholar 

  • Liaw, K.Y., Wei, T.C., Hsu, S.C.: Treatment of malignant insulinoma with atreptozotocin. J. Surg. Soc. (China) 3, 62 (1970).

    Google Scholar 

  • Lopez-Kruger, R., Dockerty, M.B.: Tumors of the islets of Langerhans. Surg. Gynec. Obstet. 85, 495 (1947).

    PubMed  CAS  Google Scholar 

  • Loutfi, A.H., Mehrez, S., Shahbender, S., Abdine, F.H.: Hypoglycaemia with Wilms’ tumour. Arch. Dis. Child. 39, 197 (1964).

    PubMed  CAS  Google Scholar 

  • Loyau, G., Kopp, J., Sauvalle, A., Porin, J.: Continuous treatment with diazoxide of hypoglycemia due to hyperinsulinism. Sem. Hop. Paris 46, 1907 (1970).

    PubMed  CAS  Google Scholar 

  • Lucey, C., Graham, W.J.: Hypoglycaemia due to retroperitoneal sarcoma with insulin-like activity. Irish J. med. Sci. 7, 413 (1968).

    PubMed  CAS  Google Scholar 

  • Lunderquist, A., Tylau, V.: Phlebography of the Pancreatic Veins. Radiologe 15, 198 (1975).

    PubMed  CAS  Google Scholar 

  • Luyckx, A.S., Lefebvre, P.Y.: Plasma insulin in reactive hypoglycemia. Diabetes 20, 435 (1971).

    PubMed  CAS  Google Scholar 

  • Madison, L.L.: Ethanol-induced hypoglycemia. Advanc. Metab. Dis. 3, 85 (1968).

    CAS  Google Scholar 

  • Mahler, R.J., Grann, V., Purdy, R.: Functioning islet cell adenoma. J. Amer. med. Ass. 188, 791 (1964).

    CAS  Google Scholar 

  • Mahon, W.A., Mitchell, M.L., Steinke, J., Raben, M.S.: Effect of human growth hormone on hypoglycemic states. New Engl. J. Med. 267, 1179 (1962).

    CAS  Google Scholar 

  • Markowitz, A.M., Slanetz, C.A., Jr., Frantz, V.K.: Functioning islet cell tumors of the pancreas: 25-year follow up. Ann. Surg. 154, 877 (1961).

    PubMed  CAS  Google Scholar 

  • Marks, V., Samols, E.: Glucagon test for insulinoma: A chemical study in 25 cases. J. clin. Path. 21, 346 (1968).

    PubMed  CAS  Google Scholar 

  • Marks, V., Samols, E., Bolton, R.: Hyperinsulinism and Cushing’s syndrome. Brit. med. J. 1965I, 1419.

    Google Scholar 

  • Marks, V.: The investigation of hypoglycemia. In: Disorders of Carbohydrate Metabolism. London: Pitman Medical Publishing 1962.

    Google Scholar 

  • Marks, V., Rose, F.C.: Hypoglycaemia. Oxford: Blackwell 1965.

    Google Scholar 

  • Marrack, D., Marks, V., Rose, F.C.: A leucine-sensitive insulinsecreting tumor. Lancet 1960II, 1329.

    Google Scholar 

  • Marshall, S.F.: Islet cell tumors of the pancreas producing hypoglycemia. Surg. clin. N. Amer. 38, 755 (1958).

    Google Scholar 

  • Martini, G.A., Strohmeyer, G., Haug, P., Gusek, W.: Inseladenom des Pankreas mit urtikariellem Exanthem, Durchfällen sowie Kalium- und Eiweißverlust über den Darm über eine besondere Verlaufsform des Zollinger-Ellison-Syndroms. Dtsch. med. Wschr. 89, 313 (1964).

    PubMed  CAS  Google Scholar 

  • Mac Cuish, A.C., Munro, J.F., Duncan, L.J.: Treatment of hypoglycaemic coma with glucagon, intravenous dextrose, and mannitol infusion in a hundred diabetics. Lancet 1970II, 946.

    Google Scholar 

  • Mac Laren, N.K., Valman, H.B., Levin, B.: Alcohol-induced hypoglycaemia in childhood. Brit, med. J. 1970I, 278.

    Google Scholar 

  • Mc Bee, J.W., Lanza, F.L., Erickson, E.E.: Hypoglycemia due to obstruction of pancreatic excretory ducts by carcinoma. Arch. Path. 81, 287 (1966).

    CAS  Google Scholar 

  • Mc Fadzean, A.J.S., Yeung, T.T.: Further observations on hypoglycemia in hepatocellular carcinoma. Amer. J. Med. 47, 220 (1969).

    CAS  Google Scholar 

  • Mc Gavran, M.H., Unger, R.H., Recant, L., Polk, H.C., Kilo, C., Levin, M.E.: A glucagon- secreting alpha-cell carcinoma of the pancreas. New Engl. J. Med. 274, 1408 (1966).

    CAS  Google Scholar 

  • Mc Intosh, H.W., Robertson, H.R., Walters, W., Randall, R.V.: Functioning islet cell carcinoma of the pancreas with metastases and prolonged survival. Arch. Surg. 80, 1021 (1960).

    Google Scholar 

  • Mc Quarrie, I.: Idiopathic spontaneously occurring hypoglycemia in infants. Amer. J. Dis. Child. 87, 399 (1954).

    CAS  Google Scholar 

  • Melani, F., Ryan, W.G., Rubenstein, A.H., Steiner, D.F.: Pro-insulin secretion by a pancreatic beta cell adenoma. New Engl. J. Med. 283, 713 (1970).

    PubMed  CAS  Google Scholar 

  • Miller, D.W., Jr., Stewart, C.F., Rosner, W.: Hypoglycemia caused by abdominal leiomyosarcoma. Amer. J. Surg. 119, 754 (1970).

    PubMed  Google Scholar 

  • Moldawer, M.: Multiple endocrine tumors and zollinger-ellison syndrome in families: One or two syndromes? Metabolism 11, 153 (1962).

    PubMed  CAS  Google Scholar 

  • Morrison, A.B., Rawson, A.J., Fitts, W.T., Jr.: The syndrome of refractory watery diarrhea and hypokalemia in patients with a non-insulin-secreting islet cell tumor. Amer. J. Med. 32, 119 (1962).

    PubMed  CAS  Google Scholar 

  • Moss, M.H.: Alcohol-induced hypoglycemia and coma caused by alcohol sponging. Pediatrics 46, 445 (1970).

    PubMed  CAS  Google Scholar 

  • Murray-Lyon, I.M., Eddleston, A.L., Williams, R.: Treatment of multiple hormone-producing malignant islet cell tumor with streptozotocin. Lancet 1968II, 895.

    Google Scholar 

  • Murphy, R.: Hypoglycemia associated with an extrapancreatic neoplasm. Med. clin. N. Amer. 47, 391 (1963).

    PubMed  CAS  Google Scholar 

  • Nagatsuka, H., Nakaima, N., Nakane, Y., Sakurai, T., Takehara, T.: Case of malignant lung tumor associated with hypoglycemia. Jap. J. Thorac. Surg. 23, 529 (1970).

    PubMed  CAS  Google Scholar 

  • Nieschlag, E., Wombacher, H., Kroeger, F.J., Habighorst, L.: Therapie eines metastasierenden Inselzelltumors mit Streptozotocin. Acta endocr. (Kbh.) 67, 405 (1971).

    CAS  Google Scholar 

  • Nissan, S., Bar-Maor, A., Shafrir, E.: Hypoglycemia associated with extrapancreatic tumors. New Engl. J. Med. 278, 177 (1968).

    PubMed  CAS  Google Scholar 

  • Nydick, M., Samols, E., Kuzuya, T., Williams, R.H.: A difficult diagnostic problem in spontaneous hypoglycemia: Reactive hypoglycemia in mild diabetes mellitus. Ann. intern. Med. 61, 1122 (1964).

    PubMed  CAS  Google Scholar 

  • O’Neill, R.T., Mikuta, J.J.: Hypoglycemia associated with serous cystadenocarcinoma of the ovary. Obstet. Gynec. 35, 287 (1970).

    PubMed  Google Scholar 

  • Oyer, P.E., Cho, S., Peterson, J.D., Steiner, D.F.: Studies on human proinsulin. Isolation and amino acid sequence of the human pancreatic C-peptide. J. biol. Chem. 246, 1375 (1971).

    PubMed  CAS  Google Scholar 

  • Papaioannou, A.N.: Tumors other than isulinomas associated with hypoglycemia. Surg. Gynec. Obstet. 123, 1093 (1966).

    Google Scholar 

  • Pellegrini, G., Solcia, E.: Hyperplasia of the islands of langerhans associated with spontaneous hypoglycemia. Arch. Ital. Chir. 93, 30 (1967).

    PubMed  CAS  Google Scholar 

  • Petrilowitsch, N., Baer, R.: Psychiatric syndrome due to hypoglycemia. Verh. dtsch. Ges. inn. Med. 75, 870 (1969).

    PubMed  CAS  Google Scholar 

  • Pfeiffer, E.F., Pfeiffer, M., Ditschuneit, H., Ahn Ahn, C.S.: Über die Bestimmung von Insulin im Blute am epididymalen Fettanhang der Ratte mit Hilfe markierter Glucose. II. Experimentelle und klinische Erfahrungen. Klin. Wschr. 37, 1239 (1959).

    PubMed  CAS  Google Scholar 

  • Podesta, A., Semino, L., Zunino, E.: Postgastrectomy hypoglycemia with special reference to the problem of hyperinsulinism in the so-called late post-cibal syndrome. Pathologica 61, 215 (1969).

    PubMed  CAS  Google Scholar 

  • Pokorski, M.: A case of severe recurrent hypoglycemia after suicidal poisoning with tolbutamides. Wiad. Lek. 22, 63 (1969).

    PubMed  CAS  Google Scholar 

  • Porter, M.R., Frantz, V.K.: Tumors associated with hypoglycemia: pancreatic and extrapancreatic. Amer. J. Med. 21, 944 (1956).

    PubMed  Google Scholar 

  • Power, L.: A glucose responsive insulinoma. J. Amer. med. Ass. 207, 893 (1969).

    CAS  Google Scholar 

  • Rae, M.V., Lewis, R.C.: Islet cell tumour in diabetes mellitus. Canad. med. Ass. J. 77, 691 (1957).

    PubMed  CAS  Google Scholar 

  • Rerup, C.: Drugs producing diabetes through damage of the insulin secreting cells. Pharm. Rev. 22, 485 (1970).

    PubMed  CAS  Google Scholar 

  • Robertson, P.D.: Carbohydrate intolerance in post-gastrectomy patients. Zrch. intern. Med. 117, 764 (1966).

    CAS  Google Scholar 

  • Rösch, J., Dotter, Ch.T.: Retrograde pancreatic venographie. Radiology 114, 275 (1975).

    PubMed  Google Scholar 

  • Rosenbloom, A.L., Sherman, L.: The natural history of idiopathic hypoglycemia of infancy and its relation to diabetes mellitus. New Engl. J. Med. 274, 815 (1966).

    PubMed  CAS  Google Scholar 

  • Rosner, L., Elstad, R.: The neuropathy of hypoglycemia. Neurology 14, 1 (1964).

    PubMed  CAS  Google Scholar 

  • Roth, D.A., Meade, R.C.: Hyperinsulinism-hypoglycemia in the postgastrectomy patient. Diabetes 14, 526 (1965).

    PubMed  CAS  Google Scholar 

  • Roth, H., Thier, S., Segal, S.: Zinc glucagon in the management of refractory hypoglycemia due to insulin-producing tumors. New Engl. J. Med. 274, (1966).

    Google Scholar 

  • Sachsse, B.: Suicide attempt with insulin. Med. Klin. 61, 1545 (1966).

    PubMed  CAS  Google Scholar 

  • Sachsse, B., Blank, H.: Funktionelle Hypoglykämie und organischer Hyperinsulinismus. Dtsch. med. Wschr. 84, 1679 (1959).

    PubMed  CAS  Google Scholar 

  • Sadoff, L.: Effects of streptozotocin in a patient with islet cell carcinoma. Diabetes 18, 675 (1969).

    PubMed  CAS  Google Scholar 

  • Sadoff, L.: The nephrotoxicity of streptozotocin. Cancer Chemother. Rep. 54, 457 (1970).

    PubMed  CAS  Google Scholar 

  • Saeed, S.M., Fine, G., Horn, R.C., Jr.: Hypoglycemia associated with extrapancreatic tumors, an immunofluorescent study. Cancer 24, 158 (1969).

    PubMed  CAS  Google Scholar 

  • Samaan, N., Lal, F., Fräser, R., Welbourn, R.B.: Insulin assays in two cases of spontaneous hypoglycaemia due to retroperitoneal mesothelioma. Brit. med. J. 2, 195 (1965).

    PubMed  CAS  Google Scholar 

  • Samols, E., Marks, V.: Insulin assay in insulinomas. Brit. med. J. 1, 507 (1963).

    PubMed  CAS  Google Scholar 

  • Sar, A. van der, Bosschieter, E., Hugenholtz, M.J., Hoeven, L. van der: Spontaneous hypogly- caemic attacks due to an insulinoma in a diabetic. Docum. Med. Geogr. Trop. 8, 85 (1956).

    Google Scholar 

  • Scheinin, T.M., Tala, E.: Diagnosis and treatment of pancreatic islet cell adenomas. Acta chir. scand. 132, 590 (1966).

    PubMed  CAS  Google Scholar 

  • Schlicke, C.P., Berghan, R.: Hypoglycemia due to islet cell tumor of the pancreas. Amer. Surg. 36, 646 (1970).

    CAS  Google Scholar 

  • Schmid, J.R., Labhart, A., Rossier, P.H.: Relationship of multiple endocrine adenomas to the syndrome of ulcerogenic islet cell adenomas (Zollinger-Ellison): Occurrence of both syndromes in one family. Amer. J. Med. 31, 343 (1961).

    PubMed  CAS  Google Scholar 

  • Schnelle, N., Molnar, G., Ferris, D., Rosevear, J., Moffitt, E.: Circulating glucose and insulin in surgery for insulinomas. J. Amer. med. Ass. 217, 1072 (1971).

    CAS  Google Scholar 

  • Scholz, D.A., Remine, W.H., Priestley, J.T.: Clinics on endocrine and metabolic diseases. 3. Hyperinsulinism: review of 95 cases of functioning pancreatic islet cell tumors. Proc. Mayo Clin. 35, 545 (1960).

    CAS  Google Scholar 

  • Seltzer, H.S., Fajans, S.S., Conn, J.W.: Spontaneous hypoglycemia as an early manifestation of diabetes mellitus. Diabetes 5, 427 (1956).

    Google Scholar 

  • Silverstein, M.N.: Tumor hypoglycemia. Cancer 23, 142 (1969).

    PubMed  CAS  Google Scholar 

  • Slone, D., Soeldner, J.S., Steinke, J., Crigler, J.F., Jr.: Serum insulin measurements in children with idiopathic spontaneous hypoglycemia and in normal infants, children and adults. New Engl. J. Med. 274, 820 (1966).

    PubMed  CAS  Google Scholar 

  • Smith, C.K., Stoll, R.W., Vance, J., Ricketts, H., Williams, R.H.: Treatment of malignant insulinoma with streptozotocin. Diabetoligia 7, 118 (1971).

    CAS  Google Scholar 

  • Spry, C.J., Williamson, D.H., James, M.L.: Pleural mesothelioma and hypoglycaemia. Proc. roy. Soc. Med. 61, 1105 (1968).

    PubMed  CAS  Google Scholar 

  • Stefanini, P., Carboni, M.: Hypoglycemic tumors of the pancreas. Diagnosis, treatment and results. Prensa Med. Argent. 57, 1345 (1970).

    PubMed  CAS  Google Scholar 

  • Steinke, J.: Hypoglycemia. In: Joslin’s Treatment of Diabetes Mellitus, 11th Ed. Philadelphia: Lea and Febiger 1971.

    Google Scholar 

  • Steinke, J., Soeldner, J.S.: Serum insulin-like activity in health and disease. In: On the Nature and Treatment of Diabetes ( B.S. Leibel, G.A. Wrenshall, Eds.). Amsterdam: Excerpta Medica 1965.

    Google Scholar 

  • Steinke, J., Soeldner, J.S.: Response of serum insulin to intravenous tolbutamide in patients with hypoglycemia. Tolbutamide… after ten years. In: Brook Lodge Symposium ( W.J. Butterfield, W.B. Westering, Eds.). Amsterdam: Excerpta Medica 1967.

    Google Scholar 

  • Steinke, J., Soeldner, J.S.: Hypoglycemia due to islet cell tumors. Proc. 14th Annual Meeting of the German Endocrine Society. Berlin-Heidelberg-New York: Springer 1968.

    Google Scholar 

  • Steinke, J., Soeldner, J.S.: Metabolic effects of diazoxide in normal subjects, patients with diabetes mellitus and patients with organic hypoglycemia. N.Y. Acad. Sci. 150, 326 (1968).

    CAS  Google Scholar 

  • Steinke, J., Soeldner, J.S., Renold, A.E.: Measurement of small quantities of insulin-like activity with rat adipose tissue. IV. Insulin-like activity and tumor insulin content in patients with functioning islet cell tumors. J. clin. Invest. 42, 1322 (1963).

    PubMed  CAS  Google Scholar 

  • Stokes, J.M., Wohltmann, H.J., Hartmann, A.J.: Pancreatectomy for refractory hypoglycemia in children. Arch. Surg. 93, 40 (1966).

    PubMed  CAS  Google Scholar 

  • Subauste, C., Calderon, R., Llerena, L.A., Carrion, E.: Insulin and insulin-like activity in tumor tissue and plasma of a patient with a fibrosarcoma associated with hypoglycemia. Metabolism 14, 881 (1965).

    PubMed  CAS  Google Scholar 

  • Sussman, K.E., Stimmler, L., Birenboim, H.: Plasma insulin levels during reactive hypoglycemia. Diabetes 15, 1 (1966).

    PubMed  CAS  Google Scholar 

  • Taylor, S.G., Schwartz, T.B., Zannini, J.Z.: Streptozotocin therapy for metastatic insulinoma. Arch, intern. Med. (Chic.) 126, 654 (1970).

    Google Scholar 

  • Tevaarwerk, G., Lowy, C., Hartog, M., Fraser, T.R.: Leucine-sensitive hypoglycaemia. Proc. roy. Soc. Med. 63, 338 (1970).

    PubMed  CAS  Google Scholar 

  • Tourniaire, J., Guinet, P., Maillet, P., Bachelot, I., Bizollon, C., Sassolas, G.: Association of hypoglycemia due to an islet cell adenoma and hyperparathyroidism due to glandular hyperplasia. Diabete 18, 245 (1970).

    PubMed  CAS  Google Scholar 

  • Tugaye, A., Daumet, P., Garnier, C., Mignot, J., Deuil, R.: Hypoglycemic par tumeur mesenchy-mateuse thoracique. Diabete 13, 317 (1965).

    Google Scholar 

  • Unger, R.H.: The riddle of tumor hypoglycemia. Amer. J. Med. 40, 325 (1966).

    PubMed  CAS  Google Scholar 

  • Unger, R.H.: Glucagon: Physiology and pathophysiology. New Engl. J. Med. 285, 443 (1971).

    PubMed  CAS  Google Scholar 

  • Vaissman, I., Kamel, D., Veloso, E., de Hercules, H.C., dos Santos, J.L., Vargas, C., Coslosvski, R., Fraga Filho, C.: Hypoglycemia associated with extrapancreatic tumors, report of 3 cases. Hospital (Rio) 75, 427 (1969).

    CAS  Google Scholar 

  • Veer, J.W. van der, Choufoer, J.C., Querido, A., Heul, R.O. van der, Hollander, C.F., Rijssel, T.G. van: Metastasising islet cell tumour of the pancreas associated with hypoglycemia and carcinoid syndrome. Lancet 1964I, 1416.

    Google Scholar 

  • Verdy, M., Cholette, J.P., Nadeau, P., Fauteux, J.P., Demay, F.: Hypoglycemic et tumeurs mesenchymateuses. Canad. med. Ass. J. 100, 470 (1969).

    PubMed  CAS  Google Scholar 

  • Volpe, R., Evans, J., Clarke, D.W., Forbath, N., Ehrlich, R.: Evidence favoring the sarcomatous origin of an insulin-like substance in a case of fibrosarcoma with hypoglycemia. Amer. J. Med. 540, (1965).

    Google Scholar 

  • Wagner, T., Spranger, J., Brunck, H.J.: Congenital alpha-cell deficiency as cause of a chronic infantile hypoglycemia. Mschr. Kinderheilk. 117, 236 (1969).

    PubMed  CAS  Google Scholar 

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  1. J. Steinke
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  2. J. Beyer
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Editor information

Editors and Affiliations

  1. Chemie Grünenthal GmbH, Zweifallstraße, D-5190, Stolberg, Germany

    R. Beckmann

  2. II. Medizinische Universitätsklinik und Poliklinik, Moorenstraße 5, D-4000, Düsseldorf, Germany

    M. Berger

  3. Am Hof 11, A-1010, Wien, Austria

    A. Beringer

  4. II. Medizinische Universitätsklinik und Poliklinik, Moorenstr. 5, D-4000, Düsseldorf, Germany

    P. Berchtold

  5. D-6500, Mainz, Germany

    J. Beyer (Leiter der Abteilung für klinische Endokrinologie an der II. Medizinischen Klinik und Poliklinik des Klinikums der Johannes Gutenbergschen Universität) (Leiter der Abteilung für klinische Endokrinologie an der II. Medizinischen Klinik und Poliklinik des Klinikums der Johannes Gutenbergschen Universität)

  6. Inselspital, CH-3010, Bern, Switzerland

    A. Bischoff (Chefarzt der Neurologischen Universitätsklinik) (Chefarzt der Neurologischen Universitätsklinik)

  7. Hautklinik, Städtische Krankenanstalten, Bremserstraße 79, D-6700, Ludwigshafen, Germany

    G. Brehm (Direktor der Hautklinik) (Direktor der Hautklinik)

  8. Diabetic and Dietetic Department, The Royal Infirmary, EH3 9YW, GB-Edinburgh, UK

    B. F. Clarke

  9. Tödisstraße 36, CH-8002, Zürich, Switzerland

    G. R. Constam

  10. Diabetic and Dietetic Department, The Royal Infirmary, EH3 9YW, GB-Edinburgh, UK

    L. J. P. Duncan

  11. Diabetes-Forschungsinstitut an der Universität, Auf’m Hennekamp 65, D-4000, Düsseldorf, Germany

    F. A. Gries (Direktor der Klinischen) (Direktor der Klinischen)

  12. Institut für Pharmakologie und Toxikologie der Universität, Geiststraße 9, D-3400, Göttingen, Germany

    A. Hasselblatt

  13. Medizinische Klinik, St. Josefskrankenhaus, Landhausstraße 25, D-6900, Heidelberg, Germany

    R. Hild

  14. 2. Medizinische Klinik und Poliklinik, Klinishe Anstalten der Universität, Moonrenstraße 5, D-4000, Düsseldorf 1, Germany

    K. Irmscher

  15. Medizinische Klinik, Städtisches Ferdinand-Sauerbruch-Klinikum, Arrenberger Straße, D-5600, Wuppertal 1, Germany

    K. Jahnke

  16. I. Medizinische Universitätsklinik, Martinistraße 52, D-2000, Hamburg 20, Germany

    J. Kühnau

  17. Evangelisches Fliedner-Krankenhaus, D-6680, Neunkirchen, Germany

    H. Liebermeister

  18. Kommunenhospitalet, 2. Medizinische Universitätsklinik, DK-Aarhus, Denmark

    K. Lundbaek

  19. Klinikum Essen, Hufelandstraße 55, D-4300, Essen 1, Germany

    G. Meyer-Schwickerath (Direktor der Universitäts-Augenklinik) (Direktor der Universitäts-Augenklinik)

  20. Wittenberger Straße 81, D-4230, Wesel 13, Germany

    Sigrid Napp-Mellinghoff

  21. Abteilung für Endokrinologie, Zentrum der Inneren Medizin, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Germany

    M. Neubauer

  22. Department für innere Medizin der Universität, Steinhövelstraße 9, D-7900, Ulm, Germany

    F. Nobbe

  23. BW-Krankenhaus, Mähringer Weg 105, D-7900, Ulm, Germany

    F. Nobbe

  24. Schloßmannstraße 32, D-4000, Düsseldorf 1, Germany

    Karl Oberdisse

  25. Heerstraße 219, D-4100, Duisburg, Germany

    P. Petrides (Chefarzt der inneren Abteilung des Bethesda-Krankenhauses) (Chefarzt der inneren Abteilung des Bethesda-Krankenhauses)

  26. Abteilung für Endokrinologie, Zentrum der Inneren Medizin der Universität, Theodor-Stern-Kai 7, D-6000, Frankfurt/Main 70, Germany

    R. Petzoldt  & K. Schöffling  & 

  27. Diabetesklinik, Wielandstraße 23, D-4970, Bad Oeynhausen, Germany

    H. Sauer

  28. Universitäts-Augenklinik, Hufelandstraße 55, D-4300, Essen 41, Germany

    M. Spitznas

  29. Augenklinik, Städtische Krankenanstalten, Hufelandstraße 55, D-4300, Essen 1, Germany

    M. Vogel

  30. Klinische Abteilung, Diabetes-Forschungsinstitut an der Universität, auf’m Hennekamp 65, D-4000, Düsseldorf 1, Germany

    K. H. Vogelberg

  31. Abteilung und Lehrstuhl IV, Retinologie, Universitäts-Augenklinik, Schleichstraße 12, D-7400, Tübungen, Germany

    A. Wessing

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Steinke, J., Beyer, J. (1977). Spontanhypoglykämien. In: Beckmann, R., et al. Diabetes mellitus • B. Handbuch der inneren Medizin, vol 7 / 2 / B. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66379-6_14

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