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Studies on the Cellular Mechanisms of Chemical Oncogenesis in Culture

  • Chapter
Fundamental Aspects of Neoplasia

Abstract

It is now almost 200 years since the remarkable paper by Percivall Pott called attention to the high incidence of cancer of the scrotum among the chimney sweeps of London and correctly attributed this to their continual contact with coal tar. Thus, 1776, in addition to being the birth date of our country was also the birth date of cancer research and of chemical carcino-genesis. It has been a repeated tragedy that many chemicals have been found to induce cancer in man before carcinogenic activity has been detected in animal tests. At present, about 20 different chemicals have been unequivocally found to produce cancer in humans, usually as a result of industrial exposure. It is now generally accepted by most epidemiologists that chemicals are the cause of 80 to 90 percent of all human cancers (17).

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Authors
  1. C. Heidelberger
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Editor information

Editors and Affiliations

  1. Department of Microbiology and Immunology, Tulane University School of Medicine, New Orleans, Louisiana, 70112, USA

    A. Arthur Gottlieb M.D. (Professor and Chairman) (Professor and Chairman)

  2. Institute of Microbiology, Rutgers University, New Brunswick, New Jersey, 08903, USA

    Otto J. Plescia Ph.D. (Professor of Immunochemistry) (Professor of Immunochemistry)

  3. The Medical Center, University of Alabama, Birmingham, Alabama, USA

    David H. L. Bishop Ph.D. (Professor of Microbiology) (Professor of Microbiology)

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© 1975 Springer-Verlag New York Inc.

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Heidelberger, C. (1975). Studies on the Cellular Mechanisms of Chemical Oncogenesis in Culture. In: Gottlieb, A.A., Plescia, O.J., Bishop, D.H.L. (eds) Fundamental Aspects of Neoplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66112-9_27

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  • DOI: https://doi.org/10.1007/978-3-642-66112-9_27

  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-66114-3

  • Online ISBN: 978-3-642-66112-9

  • eBook Packages: Springer Book Archive

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