Abstract
We have previously described the isolation and partial characterization of several DNA polymerases from the murine myeloma, MOPC 21 (1,2). In particular, we have called attention to a distinct enzyme from this line of cells (R-1 polymerase), which has the ability to utilize the synthetic polynucleotide duplex poly rA:oligo(dT)12–18 very efficiently. In this regard, R-1 polymerase resembles reverse transcriptase from the Rauscher murine leukemia virus, but it can be readily distinguished from the latter by its sedimentation coefficient and isolectric point. A summary of the comparative properties of the R-1 polymerase and the reverse transcriptase from the Rauscher murine leukemia virus are listed in Table 20-1.
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References
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Gottlieb, A.A. et al. (1975). An Inhibitor of DNA Polymerase Produced by Tumor Cells. In: Gottlieb, A.A., Plescia, O.J., Bishop, D.H.L. (eds) Fundamental Aspects of Neoplasia. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-66112-9_20
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DOI: https://doi.org/10.1007/978-3-642-66112-9_20
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