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L-Asparaginase: Basic Aspects

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Antineoplastic and Immunosuppressive Agents

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Abstract

L-Asparaginase (L-asparagine amidohydrolase, E.C.3.5.1.1) catalyzes the hydrolysis of L-asparagine to yield L-aspartic acid and ammonia. The enzyme was first reported by Lang (1904), who demonstrated its activity in various beef tissues. Confirmatory observations with tissues from horse and pig were reported a few years later by Von Furth and Friedmann (1910). The observation most pertinent to the current discussion, however, was that of Clementi (1921, 1922), who found that of numerous blood sera tested only that of the guinea pig showed L-asparaginase activity.

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Authors
  1. M. K. Patterson Jr.
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    David G. Johns M.D.

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Patterson, M.K. (1975). L-Asparaginase: Basic Aspects. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65806-8_39

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  • DOI: https://doi.org/10.1007/978-3-642-65806-8_39

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