L-Asparaginase: Basic Aspects

  • M. K. PattersonJr.
Part of the Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology book series (HEP, volume 38 / 2)


L-Asparaginase (L-asparagine amidohydrolase, E.C. catalyzes the hydrolysis of L-asparagine to yield L-aspartic acid and ammonia. The enzyme was first reported by Lang (1904), who demonstrated its activity in various beef tissues. Confirmatory observations with tissues from horse and pig were reported a few years later by Von Furth and Friedmann (1910). The observation most pertinent to the current discussion, however, was that of Clementi (1921, 1922), who found that of numerous blood sera tested only that of the guinea pig showed L-asparaginase activity.


Asparagine Synthetase Amino Acid Amide Glycoprotein Synthesis Lymphocyte Blastogenesis Asparaginase Activity 
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© springer-Verlag Berlin-Heidelberg 1975

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