Antineoplastic and Immunosuppressive Agents

Part II

  • Alan C. Sartorelli
  • David G. Johns

Table of contents

  1. Front Matter
    Pages I-XXXII
  2. Alkylating Agents

  3. Hormones

    1. Fred Rosen, Richard J. Milholland
      Pages 85-103
    2. Russell Hilf, James L. Wittliff
      Pages 104-138
    3. Russell Hilf
      Pages 139-157
    4. Bert W. O’Malley, Charles A. Strott
      Pages 158-169
  4. Antimetabolites

    1. Charles Heidelberger
      Pages 193-231
    2. William A. Creasey
      Pages 232-256
    3. D. H. W. Ho, E. J. Freireich
      Pages 257-271
    4. William H. Prusoff, Barry Goz
      Pages 272-347
    5. J. Škoda
      Pages 348-372
    6. A. R. P. Paterson, D. M. Tidd
      Pages 384-403
    7. Gertrude B. Elion, George H. Hitchings
      Pages 404-425

About this book

Introduction

Over the past two decades a number of attempts have been made, with varying degrees of success, to collect in a single treatise available information on the basic and applied pharmacology and biochemical mechanism of action of antineoplastic and immunosuppressive agents. The logarithmic growth of knowledge in this field has made it progressively more difficult to do justice to all aspects of this topic, and it is possible that the present handbook, more than four years in preparation, may be the last attempt to survey in a single volume the entire field of drugs employed in cancer chemotherapy and immunosuppression. Even in the present instance, it has proved necessary for practical reasons to publish the material in two parts, although the plan of the work constitutes, at least in the editors' view, a single integrated treatment of this research area. A number of factors have contributed to the continuous expansion of research in the areas of cancer chemotherapy and immunosuppression. Active compounds have been emerging at ever-increasing rates from experimental tumor screening systems maintained by a variety of private and governmental laboratories through­ out the world. At the molecular level, knowledge of the modes of action of established agents has continued to expand, and has permitted rational drug design to play a significantly greater role in a process which, in its early years, depended almost completely upon empirical and fortuitous observations.

Keywords

cancer chemotherapy drug immunosuppression pharmacology research

Editors and affiliations

  • Alan C. Sartorelli
    • 1
  • David G. Johns
    • 2
  1. 1.Department of PharmacologyYale University School of MedicineNew HavenUSA
  2. 2.Laboratory of Chemical Pharmacology, National Cancer InstituteNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-65806-8
  • Copyright Information Springer-Verlag Berlin Heidelberg 1975
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-65808-2
  • Online ISBN 978-3-642-65806-8
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • About this book
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