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8-Azaguanine

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Antineoplastic and Immunosuppressive Agents

Abstract

The base analog 8-azaguanine (8-azaG; guanazolo; 5-amino-7-hydroxy-l H-v-triazolo(d)pyrimidine) holds a special place in the field of cancer chemotherapy, since it was the first purine analog to display marked earcinostatic effects against murine malignancies. This base analog, which contains a nitrogen atom in place of the carbon in position 8 of the purine ring, has not proved useful for the treatment of human cancer. However, 8-azaG has provided a valuable tool for the molecular biologist, since the molecule is readily incorporated into the ribonucleic acids and appears to exert its cytotoxic action at that level.

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Authors
  1. R. E. Parks Jr.
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  2. K. C. Agarwal
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    David G. Johns M.D.

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Parks, R.E., Agarwal, K.C. (1975). 8-Azaguanine. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65806-8_22

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  • DOI: https://doi.org/10.1007/978-3-642-65806-8_22

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