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Antibiotics Resembling Adenosine: Tubercidin, Toyocamycin, Sangivamycin, Formycin, Psicofuranine, and Decoyinine

  • Chapter
Antineoplastic and Immunosuppressive Agents

Abstract

The antibiotics which resemble adenosine comprise a growing family of nucleosides with unique structures and diverse actions. Only selected members can be considered here, with emphasis on the relation of structure to metabolism and locus of action. As analogs of adenosine, these cytotoxic agents have useful application to studies exploring binding sites of adenine nucleotides and structural features of polynucleotide polymers. As more information emerges it will be feasible to classify these nucleosides, along with synthetic relatives, according to their sites of action. In this regard, a broad distinction can be made separating this family of adenosine related nucleosides from other nucleoside antibiotics, which bind at ribosomal sites to inhibit protein synthesis and which, like puromycin, bear substituents that classify them as analogs of aminoacyl-tRNA.

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Authors
  1. Charles A. Nichol
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Editors and Affiliations

  1. Department of Pharmacology, Yale University School of Medicine, 06510, New Haven, Connecticut, USA

    Alan C. Sartorelli (Professor) (Professor)

  2. Laboratory of Chemical Pharmacology, National Cancer Institute, National Institutes of Health, 20014, Bethesda, Maryland, USA

    David G. Johns M.D.

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© 1975 Springer-Verlag Berlin · Heidelberg

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Nichol, C.A. (1975). Antibiotics Resembling Adenosine: Tubercidin, Toyocamycin, Sangivamycin, Formycin, Psicofuranine, and Decoyinine. In: Sartorelli, A.C., Johns, D.G. (eds) Antineoplastic and Immunosuppressive Agents. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 38 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65806-8_21

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  • DOI: https://doi.org/10.1007/978-3-642-65806-8_21

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  • Online ISBN: 978-3-642-65806-8

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