Summary
Tamiami virus produced a lethal meningoencephalitis when inoculated peripherally into 1- to 5-day-old mice, while older and younger animals were spared. Comparison of lethally and non-lethally infected animals suggested that host factors, especially the extent of inflammatory response, determined the outcome of infection. Intracellular localization of antigen-antibody complexes coincided with recovery from disease and elimination of virus and viral antigen, suggesting a beneficial, rather than deleterious role for antibody in this disease.
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Winn, W.C., Murphy, F.A., Flemister, M.R. (1973). The Pathogenesis of Tamiami Virus Meningoencephalitis in Newborn Mice. In: Lehmann-Grube, F. (eds) Lymphocytic Choriomeningitis Virus and Other Arenaviruses. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65681-1_26
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DOI: https://doi.org/10.1007/978-3-642-65681-1_26
Publisher Name: Springer, Berlin, Heidelberg
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