Lymphocytic Choriomeningitis Virus and Other Arenaviruses

1. Front Matter

   Pages I-XIII

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2. General Introduction

   1. Front Matter

      Pages 1-1

      PDF

   2. LCM Virus Research, Retrospect and Prospects

      • E. Traub

      Pages 3-10

3. Lymphocytic Choriomeningitis Virus

   1. Front Matter

      Pages 11-11

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   2. The Virus: Purification, Chemical and Physical Properties, Complement-Fixing Antigen (s)

      1. LCM Virus: Its Purification and its Chemical and Physical Properties

         • I. R. Pedersen

         Pages 13-23

      2. Antigenic Properties of the LCM Virus: Virion and Complement-Fixing Antigen

         • H. H. Gschwender, F. Lehmann-Grube

         Pages 25-35

      3. Electron Microscopy of LCM Virus-Infected L Cells

         • Kl. Mannweiler, F. Lehmann-Grube

         Pages 37-48

   3. Interaction of LCM Virus with Cells, Including New Virus-Induced Cellular Antigens

      1. Antigenic Alteration of Cells in Vitro Infected with LCM Virus

         • G. Rutter, H. H. Gschwender

         Pages 51-59

      2. In Vitro Correlates of LCM Virus-Induced Immune Response

         • G. A. Cole, R. A. Prendergast, C. S. Henney

         Pages 61-71

      3. Histocompatibility and Lymphocytic Choriomeningitis Virus Infection

         • O. A. Holtermann, Jeaninne A. Majde

         Pages 73-81

   4. Persistent Infection in Vitro and in Vivo, Including Interference Phenomena

      1. Cyclical Transient Infection, An Explanation of Persistent Virus Infection

         • J. Hotchin

         Pages 85-99

      2. Plaque Assays and Current Concepts of Regulation in Arenavirus Infections

         • C. J. Pfau, R. M. Welsh, R. S. Trowbridge

         Pages 101-111

      3. Inapparent Infection of Syrian Hamsters with the Virus of Lymphocytic Choriomeningitis

         • U. Förster, G. Wachendörfer

         Pages 113-120

      4. Congenital LCM Virus Infection in “Germ-Free” Haas Strain Mice

         • M. Pollard, Nehama Sharon

         Pages 121-127

      5. LCM Virus-Induced Hemopoietic Disorder in Mice and its Role in the Induction of Tolerance

         • K. Bro-Jørgensen, M. Volkert

         Pages 129-137

      6. Murine LCM Virus Infection: Tolerance and Immunity

         • J. Hannover Larsen

         Pages 139-150

      7. Inhibition of Mouse Tumors and Viruses by the M-P Strain of LCM Virus

         • M. Padnos, N. Molomut

         Pages 151-163

   5. Acute and Chronic LCM Disease in Man and Animals

      1. Acute and Chronic LCM Disease

         • C. A. Mims

         Pages 167-173

      2. On the Pathogenesis of LCM Disease: Effects of Immunosuppression with Anti-Lymphocyte Serum

         • C. Lundstedt

         Pages 175-184

      3. Thymus-Dependent (T) Cell Competence in Chronic LCM Virus Infection

         • M. B. A. Oldstone

         Pages 185-193

Four decades ago, lymphocytic choriomeningitis virus was discovered, at about the same time and independently, in 3 different localities in the U.S.A. Armstrong and Lillie encountered the agent in a monkey when they passaged a recent isolate of the St. Louis encephalitis virus; Rivers and Scott isolated 5 strains from patients with meningitis; and Traub revealed the virus in a colony of albino mice. Already in these first isolations mice were incriminated, and later observa­ tions proved beyond doubt that M. musculus is the principal reservoir of the virus in nature. For some time LCM virus was regarded as the sole etiologic agent of Wallgren's "meningite aseptique aigue". Soon, however, it became clear that Wallgren's syndrome had a multitude of causes, among which the LCM virus was of little relevance, and in subsequent years it disappeared from the sight of most viro­ logists. Indeed, it might have fallen into oblivion had it not been for Erich Traub who, practically all by himself, continued to investigate the intricate relationship between this virus and its natural host, the common house mouse.

• Antigen
• Immunologie
• Thymus
• biology
• cell
• central nervous system
• histocompatibility
• immunology
• immunosuppression
• infection
• infections
• nervous system
• pathogenesis
• virology
• virus

Policies and ethics