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Intrarenal Action of Angiotensin

  • Chapter
Angiotensin

Abstract

This chapter is concerned with the intrarenal action of angiotensin. The treatment of this subject has become extremely difficult during the last few years, as many observations indicate that angiotensin II is formed intrarenally in the vicinity of the juxtaglomerular apparatus (JGA). Here, specialized cells produce the enzyme renin, which is essential for the formation of Ang. II. Because the activity of this enzyme, like that of angiotensinase, is not homogeneously distributed among all JGAs in the kidney but varies according to the position of the JGA in different layers of the renal cortex (Brown et al., 1965, 1966; Cook et al., 1956; Granger et al., 1972; Peart, 1959), it is clear that any study must take this intrarenal pattern of enzyme activity into account. These aspects exclude the possibility of simulating the action associated with naturally occurring angiotensin by injecting this substance into the blood perfusing the kidney. The injection of synthetic angiotensin would be expected not only to have a uniform distribution within the entire kidney, but also to act upon vascular and tubular segments, which may not normally be exposed to intrarenally formed angiotensin. Therefore, the events following the exogenous administration of synthetic angiotensin may have little relation to in-vivo mechanisms.

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  1. Klaus Thurau
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Editors and Affiliations

  1. The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    Irvine H. Page M.D. (Emeritus Director of Research) (Emeritus Director of Research)

  2. Division of Research, The Cleveland Clinic Foundation, 44106, Cleveland, OH, USA

    F. Merlin Bumpus Ph.D. (Chairman) (Chairman)

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Thurau, K. (1974). Intrarenal Action of Angiotensin. In: Page, I.H., Bumpus, F.M. (eds) Angiotensin. Handbuch der experimentellen Pharmakologie / Handbook of Experimental Pharmacology, vol 37. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65600-2_26

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