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Glucuronide-Forming Enzymes

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Concepts in Biochemical Pharmacology

Abstract

Glucuronides, or β-D-glucosiduronic acids, are formed when a molecule condenses with the C-1 atom of glucuronic acid; the free carboxyl group at C-6 ensures polarity of the resulting conjugate, which is usually more water-soluble than the free aglycon and therefore more rapidly transported in, or excreted from, the organism. Glucuronide formation is the commonest conjugation in mammals, presumably from the ready availability of glucuronic acid in the tissues and the many chemical groups forming glucuronides. Enzymes catalyzing glucuronide synthesis have been widely, if not deeply, studied and exhaustive references up to 1965 are available (Dutton, 1966 b). Since then several questions, and a few answers, have been clarified; the present review will attempt to cover later significant work, but can only summarise earlier findings and indicate sources of further information.

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Dutton, G.J. (1971). Glucuronide-Forming Enzymes. In: Brodie, B.B., Gillette, J.R., Ackerman, H.S. (eds) Concepts in Biochemical Pharmacology. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 28 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65177-9_24

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