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Concepts in Biochemical Pharmacology

Part 2

  • Bernard B. Brodie
  • James R. Gillette
  • Helen S. Ackerman

Table of contents

  1. Front Matter
    Pages II-XX
  2. Methods of Studying the Metabolism of Drugs

    1. Assay of Drugs and Their Metabolites

      1. R. P. Maickel, T. R. Bosin
        Pages 9-20
      2. Helen S. Ackerman, Sidney Udenfriend
        Pages 21-41
      3. R. P. Maickel, W. R. Snodgrass, R. Kuntzman
        Pages 42-57
      4. R. Kuntzman, R. H. Cox Jr., R. P. Maickel
        Pages 58-62
      5. M. W. Anders
        Pages 63-93
      6. A. K. Cho
        Pages 94-107
      7. Marthe Vogt
        Pages 108-117
      8. S. Spector
        Pages 118-122
    2. Isolation and Identification of Drug Metabolites

      1. Vincent T. Oliverio, Anthony M. Guarino
        Pages 160-177
      2. A. M. Guarino, H. M. Fales
        Pages 178-208
  3. Sites of Drug Metabolism

    1. R. T. Williams
      Pages 226-242
    2. Microsomal Enzymes

    3. Nonmicrosomal Enzymes

  4. Back Matter
    Pages 684-778

About this book

Introduction

This volume of the Handbook of Experimental Pharmacology (Concepts in Biochemical Pharmacology) will show that pharma­ cology has finally arrived as a true discipline in its own right, and is no longer the handmaiden of organic chemistry and physiology. Instead it is an amalgam of all the biological sciences including biochemistry, biophysical chemistry, physiology, pathology and clinical medicine. In the volumes that make up Concepts in Bio­ chemical Pharmacology we hope to convince Medical Schools what should now be obvious, that pharmacology is no longer that dull topic bridging the basic sciences with medicine, but is probably the most important subject in the medical curriculum. We are grateful for the advice of Dr. Byron Clark, Director of the Pharmacology-Toxicology Program at the National Institutes of Health whose support made possible much of the work described in this volume. Contents Section Four: Methods 01 Stooging the MetoholiBm 01 Drugs Subsection A. Assay 01 Drugs and Their M etoholites Chapter 22 : Basic Principles in Development of Methods for Drug Assay. B. B. BRODIE. With 2 Figures 1 1 A. Introduction . . . . . . . . . . B. Principles of Developing a Method. . . . . . 1 I. Section of Method of Assay . . . . . . 1 II. Choice of Solvent for Extraction of Drug 2 III. Adsorption of Drugs by Glass Surfaces . . . . . . . . . . . . . . 3 IV. Recoveries of Known Amounts of Compound from Biological Material. 4 V. Assessment of Sensitivity 5 VI. Assessment of Specificity 5 References. . . . . . . . . . .

Keywords

assessment biochemistry chemistry drug medicine organic chemistry pathology pharmacology physiology research toxicology

Editors and affiliations

  • Bernard B. Brodie
    • 1
  • James R. Gillette
    • 1
  • Helen S. Ackerman
  1. 1.Department of Health, Education and WelfareNational Institutes of HealthBethesdaUSA

Bibliographic information

  • DOI https://doi.org/10.1007/978-3-642-65177-9
  • Copyright Information Springer-Verlag Berlin Heidelberg 1971
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Springer Book Archive
  • Print ISBN 978-3-642-65179-3
  • Online ISBN 978-3-642-65177-9
  • Series Print ISSN 0171-2004
  • Series Online ISSN 1865-0325
  • Buy this book on publisher's site
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