Abstract
In 1955 it was first established by isotope experiments with 18O labeled oxygen that the oxygen molecule does not only serve as an electron acceptor in biological oxidations, but is also used by special enzymes for a direct oxygenation of organic compounds (Mason et al., 1955). If both oxygen atoms of the molecule are introduced into the substrate the enzymes are termed dioxygenases (Hayaishi, 1962). The more important group of the oxygenases uses one atom of oxygen for the oxygenation of the substrate and therefore, these enzymes are called monooxygenases according to the terminology of Hayaishi (1968). These enzymes are more commonly known as mixed function oxidases (Mason, 1957) or mixed function oxygenases since they have a second function as oxidases when reducing the second oxygen atom to water according to the equation: \( RH\,\, + \,\,{O_2}\,\, + \,\,D{H_2}\,\, = \,\,ROH\,\, + \,\,{H_2}O\,\, + \,\,D \) DH2 as an external electron donor is an essential cofactor for these enzymatic reactions.
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Ullrich, V., Staudinger, H. (1971). Model Systems in Studies of the Chemistry and the Enzymatic Activation of Oxygen. In: Brodie, B.B., Gillette, J.R., Ackerman, H.S. (eds) Concepts in Biochemical Pharmacology. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 28 / 2. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-65177-9_16
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