Viren und die Entstehung hämatologischer Neoplasien

  • Melanie M. Brinkmann
  • Nils von Neuhoff
  • Hans L. Tillmann
  • Thomas E. Schulz
Part of the Molekulare Medizin book series (MOLMED)


Anfang des 20. Jahrhunderts erbrachten Ellermann u. Bang (1908) den ersten Beweis, dass Leukämien und Lymphome durch Viren induziert werden können. Sie zeigten, dass eine Form der Leukämie bei Hühnern durch ein filtrierbares Agens ausgelöst wird. Diese Beobachtung konnte durch weitere Beispiele von natürlich auftretenden Tumoren in Hühnern (Sarkome, Myelomastose) gestützt werden. Über viele Jahre galten Vögel als die einzigen Lebewesen, bei denen Viren als Ursache für die Entstehung von Tumoren bekannt waren. Erst in den folgenden Jahrzehnten wurden auch bei Mäusen, Katzen und Rindern Leukämien und Lymphome entdeckt, deren Genese mit dem Einfluss von Viren in Verbindung gebracht werden konnte (Gross 1951; Jarrett et al. 1964; Van der Maaten et al. 1972).


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Copyright information

© Springer-Verlag Berlin Heidelberg 2003

Authors and Affiliations

  • Melanie M. Brinkmann
  • Nils von Neuhoff
  • Hans L. Tillmann
  • Thomas E. Schulz

There are no affiliations available

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