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Viren und die Entstehung hämatologischer Neoplasien

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Molekularmedizinische Grundlagen von hämatologischen Neoplasien

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Anfang des 20. Jahrhunderts erbrachten Ellermann u. Bang (1908) den ersten Beweis, dass Leukämien und Lymphome durch Viren induziert werden können. Sie zeigten, dass eine Form der Leukämie bei Hühnern durch ein filtrierbares Agens ausgelöst wird. Diese Beobachtung konnte durch weitere Beispiele von natürlich auftretenden Tumoren in Hühnern (Sarkome, Myelomastose) gestützt werden. Über viele Jahre galten Vögel als die einzigen Lebewesen, bei denen Viren als Ursache für die Entstehung von Tumoren bekannt waren. Erst in den folgenden Jahrzehnten wurden auch bei Mäusen, Katzen und Rindern Leukämien und Lymphome entdeckt, deren Genese mit dem Einfluss von Viren in Verbindung gebracht werden konnte (Gross 1951; Jarrett et al. 1964; Van der Maaten et al. 1972).

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Authors
  1. Melanie M. Brinkmann
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  2. Nils von Neuhoff
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  3. Hans L. Tillmann
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  4. Thomas E. Schulz
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Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Intitut für Zell- und Molekularpathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30623, Hannover, Deutschland

    Brigitte Schlegelberger

  3. Medizinische Fakultät, Institut für Medizinische Biologie, Universität Wien, Währinger Gürtel 10, A-1090, Wien IX, Österreich

    Christa Fonatsch

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Brinkmann, M.M., von Neuhoff, N., Tillmann, H.L., Schulz, T.E. (2003). Viren und die Entstehung hämatologischer Neoplasien. In: Ganten, D., Ruckpaul, K., Schlegelberger, B., Fonatsch, C. (eds) Molekularmedizinische Grundlagen von hämatologischen Neoplasien. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59343-7_7

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