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Hochmaligne B-Zell-Lymphome

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Molekularmedizinische Grundlagen von hämatologischen Neoplasien

Part of the book series: Molekulare Medizin ((MOLMED))

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Zusammenfassung

Erst in diesem Jahr ist durch die WHO-Klassifikation eine weltweit akzeptierte Basis für die histopathologische Beurteilung der malignen Lymphome geschaffen worden. Über Jahrzehnte hinweg waren die wissenschaftliche Diskussion und die Interpretation klinischer Daten insbesondere zu hochmalignen B-Zell-Lymphomen durch die unterschiedlichen Klassifikationssysteme erschwert: In den USA wurde überwiegend die so genannte Working Formulation benutzt, die ursprünglich nicht als eigenständiges Klassifikationssystem, sondern als „Übersetzungshilfe“für verschiedene, nicht vereinbare Klassifikationssysteme zum Vergleich klinischer Studien konzipiert war. In Europa fand dagegen die 1974 vorgestellte und 1988 überarbeitete Kiel-Klassifikation Anwendung, die auf dem Prinzip beruht, die Non-Hodgkin-Lymphome auf der Basis des zytologischen Erscheinungsbilds einzuteilen (Stansfeld et al. 1988; Lennert u. Feller 1992).

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Authors
  1. Brigitte Schlegelberger
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  2. Martin Lipp
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Editors and Affiliations

  1. Max-Delbrück-Centrum für Molekulare Medizin, Robert-Rössle-Str. 10, 13122, Berlin-Buch, Deutschland

    Detlev Ganten  & Klaus Ruckpaul  & 

  2. Intitut für Zell- und Molekularpathologie, Medizinische Hochschule Hannover, Carl-Neuberg-Straße 1, 30623, Hannover, Deutschland

    Brigitte Schlegelberger

  3. Medizinische Fakultät, Institut für Medizinische Biologie, Universität Wien, Währinger Gürtel 10, A-1090, Wien IX, Österreich

    Christa Fonatsch

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Schlegelberger, B., Lipp, M. (2003). Hochmaligne B-Zell-Lymphome. In: Ganten, D., Ruckpaul, K., Schlegelberger, B., Fonatsch, C. (eds) Molekularmedizinische Grundlagen von hämatologischen Neoplasien. Molekulare Medizin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-59343-7_15

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