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Primäre Hypertonie

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Arterielle Hypertonie
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Zusammenfassung

Eine arterielle Hypertonie wurde nach früheren Schätzungen bei etwa 10–15% der erwachsenen Bevölkerung der westlichen Zivilisationsländer vermutet. Da diese Prozentzahlen jedoch auf den damaligen Definitionen der arteriellen Hypertonie basierten (≥160/95 mmHg), ist der Anteil der Hypertoniker nach der heute üblichen Klassifizierung (≥140 mmHg systolisch und/oder ≥90 mmHg diastolisch) als deutlich höher anzunehmen (Tabelle 9.1). Es ist daher verständlich, dass die arterielle Hypertonie die von Hausärzten am häufigsten gestellte Diagnose bei erwachsenen Patienten ist. Als Ursache für die dauerhafte Blutdruckerhöhung wird bei 95–99% aller betroffenen Patienten eine primäre Hypertonie diagnostiziert.

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Literatur

  • Andronico G, Mule G, Mangano MT, Piazza G, Donatelli M, Cerasola G, Bompiano GD (1992) Insulin resistance and endogenous digoxin-like factor in obese hypertensive patients with glucose intolerance. Acta Diabetol 28:203–205

    Article  PubMed  CAS  Google Scholar 

  • Annest JL, Sing CF, Biron P, Mongeau JG (1979) Familial aggregation of blood pressure and weight in adoptive families: II. Estimation of the relative contribution of genetics and common environmental factors to blood pressure correlations between family members. Am J Epidemiol 110:492–503

    PubMed  CAS  Google Scholar 

  • Blaustein MP (1977) Sodium ions, calcium ions, blood pressure regulation and hypertension: a reassessment and a hypothesis. Am J Physiol 232:C165–C173

    PubMed  CAS  Google Scholar 

  • Buckalew VM, Gonick HC (1998) Summary of a symposium on natriuretic and digitalis-like factors. Clin Exper Hypertension 20(5, 6):481–488

    Article  Google Scholar 

  • Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D (1995) Prevalence of hypertension in the US adult population. Results from the third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25:305–313

    Article  PubMed  CAS  Google Scholar 

  • Carroll D, Smith GD, Sheffield D, Shipley MJ, Marmot MG (1995) Pressor reactions to psychological stress and prediction of future blood pressure: data from the Whitehall II study. Br Med J 310:771–776

    Article  CAS  Google Scholar 

  • Cusi D, Barlassina C, Azzani T, Casari G, Cittero L, Devoto M, Glorioso N, Lanzani C, Manunta P, Righetti M, Rivera R, Stella P, Troffa C, Zagato L, Bianchi G (1997) Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 349:1353–1357

    Article  PubMed  CAS  Google Scholar 

  • Cutler JA, Kotchen TA, Obarzanek E (eds) (1991) The National Heart, Lung, and Blood Institute workshop on salt and blood pressure. Hypertension 17(suppl I):I-1-1-221

    Google Scholar 

  • Davidson MB (1995) Clinical implications of insulin resistance syndromes. Am J Med 99:420–426

    Article  PubMed  CAS  Google Scholar 

  • Elliott P (1991) Observational studies of salt and blood pressure. Hypertension 17(suppl I):I-3-I-8

    Google Scholar 

  • Ferrandi M, Manunta P (2000) Ouabain-like factor: is this the natriuretic hormone? Curr Opin Nephrol Hypertens 9:165–171

    Article  PubMed  CAS  Google Scholar 

  • Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Olegini M, Graziadei L, Pedrinellia R, Brandi L, Bevilacqua S (1987) Insulin resistance in essential hypertension. N Engl J Med 317:350–356

    Article  PubMed  CAS  Google Scholar 

  • Ganten D, Schmidt S, Paul M (1994) Genetics of primary hypertension. J Cardiovasc Pharmacol 24(suppl 3):S45–S50

    PubMed  CAS  Google Scholar 

  • Goldstein DS (1983) Plasma catecholamines and essential hypertension. An analytical review. Hypertension 5:86–99

    Article  PubMed  CAS  Google Scholar 

  • Gottsdiener JS, Reda DJ, Materson BJ, Massie BM, Notargiacomo A, Hamburger RJ, Williams DW, Henderson WG (1994) Importance of obesity, race and age to the cardiac structural and functional effects of hypertension. J Am Coll Cardiol 24:1492–1498

    Article  Google Scholar 

  • Hall JE (ed) (1992) The kidney, obesity, and essential hypertension symposium. Jackson, Miss., March 15-16, 1991. Hypertension 19(suppl I):I-1-I-135

    Google Scholar 

  • Hamet P (1999) Genes and hypertension. Where are we and where we should go. Clin Exper Hypertension 21(5, 6):947–960

    Article  CAS  Google Scholar 

  • Hamet P, Pausova Z, Adarichev V, Adarichev K, Tremblay J (1998) Hypertension: genes and environment. J Hypertension 16:397–418

    Article  CAS  Google Scholar 

  • Harrap S (1994) Hypertension: genes versus environment. Lancet 344:167–171

    Article  Google Scholar 

  • Herbold M, Hense HW, Keil U (1989) Effects of road traffic noise on prevalence of hypertension in men: results of the Lübeck blood pressure study. Soz Präventivmed 34:19–23

    Article  PubMed  CAS  Google Scholar 

  • Hauner H (1998) Adipositas und Leptin. Dtsch med Wschr 123:1315–1316

    Article  PubMed  CAS  Google Scholar 

  • Hinson JP, Dawnay AB, Raven PW (1995) Why we should give a qualified welcome to ouabain: a whole new family of adrenal steroid hormones. J Endocrinol 146:369–372

    Article  PubMed  CAS  Google Scholar 

  • Hirose H, Saito I, Tsujioka M, Mori M, Kawabe H, Saruta T (1998) The obese gene product, leptin: possible role in obesity-related hypertension in adolescents. J Hypertension 16:2007–2012

    Article  CAS  Google Scholar 

  • Januszewicz A (1995) The natriuretic peptides in hypertension. Curr Opin Cardiol 10:495–500

    Article  PubMed  CAS  Google Scholar 

  • Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, Corvol C (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71:169–180

    Article  PubMed  CAS  Google Scholar 

  • Kahn CR (1995) Causes of insulin resistance. Nature 373:384–385

    Article  PubMed  CAS  Google Scholar 

  • Kainulainen K, Perola M, Terwilliger J, Kaprio J, Koskenvuo M, Syvanen AC et al (1999) Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension. Hypertension 33:844–899

    Article  PubMed  CAS  Google Scholar 

  • Kannel WB, Brand N, Skinner JJ Jr, Dawber TR, McNamara PM (1967) Relation of adiposity to blood pressure and development of hypertension: The Framingham Study. Ann Intern Med 67:48–59

    PubMed  CAS  Google Scholar 

  • Kaplan NM (1998) Clinical Hypertension. 7th edition. Williams & Wilkins, New York

    Google Scholar 

  • Kotchen TA, Kotchen JM, Grim CE, George V, Kaldunski ML, Cowley AW, Hamet P, Chelius TH (2000) Genetic determinants of hypertension. Identification of candidate phenotypes. Hypertension 36:7–13

    Article  PubMed  CAS  Google Scholar 

  • Kunz R, Kreutz R, Beige J, Distler A, Sharma AM (1997) Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal. Hypertension 30:1331–1337

    Article  PubMed  CAS  Google Scholar 

  • Kurtz T (1994) Genetic models of hypertension. Lancet 344:167–168

    Article  PubMed  CAS  Google Scholar 

  • Landsberg L (1992) Hyperinsulinemia: Possible Role in obesity-induced hypertension. Hypertension 19(suppl I):I-61-1-66

    Google Scholar 

  • Landsberg L (1986) Diet, obesity and hypertension: An hypothesis involving insulin, the sympathetic nervous system, and adaptative thermogenesis. Q J Med 236:1081–1090

    Google Scholar 

  • Levine RS, Hennekens CH, Jesse MJ (1994) Blood pressure in prospective population based cohort of newborn and infant twins. Br Med J 308:298–302

    Article  CAS  Google Scholar 

  • Lindquist TL, Beilin LJ, Knuiman MW (1997) Influence of lifestyle, coping, and job stress on blood pressure in men and women. Hypertension 29:1–7

    Article  PubMed  CAS  Google Scholar 

  • Lund-Johansen P (1991) Twenty-year follow-up of hemodynamics in essential hypertension during rest and exercise. Hypertension 18(suppl III):III-54-III-61

    Google Scholar 

  • Liischer TF, Seo B, Bühler F (1993) Potential role of endothelin in hypertension. Controversy on endothelin in hypertension. Hypertension 21:752–757

    Article  Google Scholar 

  • Luft FC, Weinberger MH, Grim CE (1982) Sodium sensitivity and resistance in normotensive humans. Am J Med 72:726–736

    Article  PubMed  CAS  Google Scholar 

  • Masuo K, Mikami H, Ogihara T, Tuck ML (2000) Weight gain-induced blood pressure elevation. Hypertension 35:1135–1140

    Article  PubMed  CAS  Google Scholar 

  • Morris AD, Petrie JR, Connell JMC (1994) Insulin and hypertension. J Hypertension 12:633–642

    Article  CAS  Google Scholar 

  • O’Donell CJ, Lindpaintner K, Larsson MG, Rao VS, Ordovas JM, Schaefer EJ et al (1998) Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not in women in the Framingham Heart Study. Circulation 97:1766–1772

    Article  Google Scholar 

  • Oparil S, Carretero OA (2000) Essential hypertension. Part 1: Definition and etiology. Circulation 101:329–335

    Article  PubMed  Google Scholar 

  • Regecova V, Kellerova E (1995) Effects of urban noise pollution on blood pressure and heart rate in preschool children. J Hypertension 13:405–412

    CAS  Google Scholar 

  • Reisin E (1990) Sodium and obesity in the pathogenesis of hypertension. Am J Hypertension 3:164–167

    CAS  Google Scholar 

  • Ribstein J, du Cailar G, Mimran A (1995) Combined renal effects of overweight and hypertension. Hypertension 26:610–615

    Article  PubMed  CAS  Google Scholar 

  • Roccini AP (1992) Cardiovascular regulation in obesity-induced hypertension. Hypertension 19(suppl I):I-56-I-60

    Google Scholar 

  • Scherrer U, Sartori C (1997) Insulin as a vascular and sympthoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation 96:4104–4113

    Article  PubMed  CAS  Google Scholar 

  • Schiffrin EL (1995) Endothelin: potential role in hypertension and vascular hypertrophy. Hypertension 25:1135–1145

    Article  PubMed  CAS  Google Scholar 

  • Schmidt S, van Hooft LMS, Grobbee DE, Ganten D, Ritz E (1993) Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure. Dutch Hypertension and Offspring Study. J Hypertension 11:345–348

    Article  CAS  Google Scholar 

  • Schmidt S, Sharma AM, Zilch O, Beige J, Walla-Friedel M, Ganten D, Distler A, Ritz E (1995) Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset. Nephrol Dial Transplant 10:1145–1148

    PubMed  CAS  Google Scholar 

  • Schmidt S, Ganten D (1994) Genetics of primary hypertension. (Editorial Comment) Nephrol Dial Transplant 9:473–474

    CAS  Google Scholar 

  • Sharma AM, Distler A, Luft FC (1994) Strategien zur Erforschung der Genetik des Bluthochdrucks. Dtsch med Wschr 119:742–746

    Article  PubMed  CAS  Google Scholar 

  • Sinclair AM, Isles CG, Brown I, Cameron H, Murray GD, Robertson JWK (1987) Secondary hypertension in a blood pressure clinic. Arch Intern Med 147:1289–1293

    Article  PubMed  CAS  Google Scholar 

  • Stamler R, Stamler J, Riedlinger WF, Algera G, Roberts RJ (1978) Weight and blood pressure: Findings in hypertension screening of one million Americans. JAMA 240:1607–1610

    Article  PubMed  CAS  Google Scholar 

  • Stamler J, Rose G, Elliott P, Marmot M, Kesteloot H, Stamler R (1991) Findings of the international cooperative INTERSALT study. Hypertension 17(suppl I):I-9-I-15

    Google Scholar 

  • Stamler J (1991) Implications of the INTERSALT study. Hypertension 17(suppl I):I-16-I-20

    Google Scholar 

  • Stimpel M, Kaufmann W, Wambach G (1988) Atriales natriuretisches Peptid (ANP) bei essentieller Hypertonie: Humoraler Marker für Kochsalzsensitivität und hypertensive Herzkrankheit im klinisch-asymptomatischen Stadium? Z Kardiol 77(suppl 2):92–98

    PubMed  Google Scholar 

  • Vanhoutte PM (1993) Is endothelin involved in the pathogenesis of hypertension? Hypertension 21:747–751

    Article  PubMed  CAS  Google Scholar 

  • Williams B (1994) Insulin resistance: the shape of things to come. Lancet 344:521–524

    Article  PubMed  CAS  Google Scholar 

  • Williams GH (1994) Essential hypertension as an endocrine disease. Endocrinol Metab Clin N Am 23:429–444

    CAS  Google Scholar 

  • Williams SM, Addy JH, Phillips JA, Dai M, Kpodonu J, Afful J, Jackson H, Joseph K, Eason F, Murray MM, Epperson P, Aduonum A, Wong L-J, Jose PA, Felder RA (2000) Combinations of variations in multiple genes are associated with hypertension. Hypertension 36:2–6

    Article  PubMed  CAS  Google Scholar 

  • Woolfson RG, Poston L, De Wardener HE (1994) Digoxin-like inhibitors of active sodium transport and blood pressure: the current status. Kidney Int 46:297–309

    Article  PubMed  CAS  Google Scholar 

  • Zanchetti A (1994) Hyperlipidaemia in the hypertensive patient. Am J Med. 96(suppl 6A): 3S–8S

    Article  PubMed  CAS  Google Scholar 

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Stimpel, M. (2001). Primäre Hypertonie. In: Arterielle Hypertonie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57617-1_9

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  • DOI: https://doi.org/10.1007/978-3-642-57617-1_9

  • Publisher Name: Steinkopff, Heidelberg

  • Print ISBN: 978-3-642-63309-6

  • Online ISBN: 978-3-642-57617-1

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