Zusammenfassung
Eine arterielle Hypertonie wurde nach früheren Schätzungen bei etwa 10–15% der erwachsenen Bevölkerung der westlichen Zivilisationsländer vermutet. Da diese Prozentzahlen jedoch auf den damaligen Definitionen der arteriellen Hypertonie basierten (≥160/95 mmHg), ist der Anteil der Hypertoniker nach der heute üblichen Klassifizierung (≥140 mmHg systolisch und/oder ≥90 mmHg diastolisch) als deutlich höher anzunehmen (Tabelle 9.1). Es ist daher verständlich, dass die arterielle Hypertonie die von Hausärzten am häufigsten gestellte Diagnose bei erwachsenen Patienten ist. Als Ursache für die dauerhafte Blutdruckerhöhung wird bei 95–99% aller betroffenen Patienten eine primäre Hypertonie diagnostiziert.
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Literatur
Andronico G, Mule G, Mangano MT, Piazza G, Donatelli M, Cerasola G, Bompiano GD (1992) Insulin resistance and endogenous digoxin-like factor in obese hypertensive patients with glucose intolerance. Acta Diabetol 28:203–205
Annest JL, Sing CF, Biron P, Mongeau JG (1979) Familial aggregation of blood pressure and weight in adoptive families: II. Estimation of the relative contribution of genetics and common environmental factors to blood pressure correlations between family members. Am J Epidemiol 110:492–503
Blaustein MP (1977) Sodium ions, calcium ions, blood pressure regulation and hypertension: a reassessment and a hypothesis. Am J Physiol 232:C165–C173
Buckalew VM, Gonick HC (1998) Summary of a symposium on natriuretic and digitalis-like factors. Clin Exper Hypertension 20(5, 6):481–488
Burt VL, Whelton P, Roccella EJ, Brown C, Cutler JA, Higgins M, Horan MJ, Labarthe D (1995) Prevalence of hypertension in the US adult population. Results from the third National Health and Nutrition Examination Survey, 1988-1991. Hypertension 25:305–313
Carroll D, Smith GD, Sheffield D, Shipley MJ, Marmot MG (1995) Pressor reactions to psychological stress and prediction of future blood pressure: data from the Whitehall II study. Br Med J 310:771–776
Cusi D, Barlassina C, Azzani T, Casari G, Cittero L, Devoto M, Glorioso N, Lanzani C, Manunta P, Righetti M, Rivera R, Stella P, Troffa C, Zagato L, Bianchi G (1997) Polymorphisms of alpha-adducin and salt sensitivity in patients with essential hypertension. Lancet 349:1353–1357
Cutler JA, Kotchen TA, Obarzanek E (eds) (1991) The National Heart, Lung, and Blood Institute workshop on salt and blood pressure. Hypertension 17(suppl I):I-1-1-221
Davidson MB (1995) Clinical implications of insulin resistance syndromes. Am J Med 99:420–426
Elliott P (1991) Observational studies of salt and blood pressure. Hypertension 17(suppl I):I-3-I-8
Ferrandi M, Manunta P (2000) Ouabain-like factor: is this the natriuretic hormone? Curr Opin Nephrol Hypertens 9:165–171
Ferrannini E, Buzzigoli G, Bonadonna R, Giorico MA, Olegini M, Graziadei L, Pedrinellia R, Brandi L, Bevilacqua S (1987) Insulin resistance in essential hypertension. N Engl J Med 317:350–356
Ganten D, Schmidt S, Paul M (1994) Genetics of primary hypertension. J Cardiovasc Pharmacol 24(suppl 3):S45–S50
Goldstein DS (1983) Plasma catecholamines and essential hypertension. An analytical review. Hypertension 5:86–99
Gottsdiener JS, Reda DJ, Materson BJ, Massie BM, Notargiacomo A, Hamburger RJ, Williams DW, Henderson WG (1994) Importance of obesity, race and age to the cardiac structural and functional effects of hypertension. J Am Coll Cardiol 24:1492–1498
Hall JE (ed) (1992) The kidney, obesity, and essential hypertension symposium. Jackson, Miss., March 15-16, 1991. Hypertension 19(suppl I):I-1-I-135
Hamet P (1999) Genes and hypertension. Where are we and where we should go. Clin Exper Hypertension 21(5, 6):947–960
Hamet P, Pausova Z, Adarichev V, Adarichev K, Tremblay J (1998) Hypertension: genes and environment. J Hypertension 16:397–418
Harrap S (1994) Hypertension: genes versus environment. Lancet 344:167–171
Herbold M, Hense HW, Keil U (1989) Effects of road traffic noise on prevalence of hypertension in men: results of the Lübeck blood pressure study. Soz Präventivmed 34:19–23
Hauner H (1998) Adipositas und Leptin. Dtsch med Wschr 123:1315–1316
Hinson JP, Dawnay AB, Raven PW (1995) Why we should give a qualified welcome to ouabain: a whole new family of adrenal steroid hormones. J Endocrinol 146:369–372
Hirose H, Saito I, Tsujioka M, Mori M, Kawabe H, Saruta T (1998) The obese gene product, leptin: possible role in obesity-related hypertension in adolescents. J Hypertension 16:2007–2012
Januszewicz A (1995) The natriuretic peptides in hypertension. Curr Opin Cardiol 10:495–500
Jeunemaitre X, Soubrier F, Kotelevtsev YV, Lifton RP, Williams CS, Charru A, Hunt SC, Hopkins PN, Williams RR, Lalouel JM, Corvol C (1992) Molecular basis of human hypertension: role of angiotensinogen. Cell 71:169–180
Kahn CR (1995) Causes of insulin resistance. Nature 373:384–385
Kainulainen K, Perola M, Terwilliger J, Kaprio J, Koskenvuo M, Syvanen AC et al (1999) Evidence for involvement of the type 1 angiotensin II receptor locus in essential hypertension. Hypertension 33:844–899
Kannel WB, Brand N, Skinner JJ Jr, Dawber TR, McNamara PM (1967) Relation of adiposity to blood pressure and development of hypertension: The Framingham Study. Ann Intern Med 67:48–59
Kaplan NM (1998) Clinical Hypertension. 7th edition. Williams & Wilkins, New York
Kotchen TA, Kotchen JM, Grim CE, George V, Kaldunski ML, Cowley AW, Hamet P, Chelius TH (2000) Genetic determinants of hypertension. Identification of candidate phenotypes. Hypertension 36:7–13
Kunz R, Kreutz R, Beige J, Distler A, Sharma AM (1997) Association between the angiotensinogen 235T-variant and essential hypertension in whites: a systematic review and methodological appraisal. Hypertension 30:1331–1337
Kurtz T (1994) Genetic models of hypertension. Lancet 344:167–168
Landsberg L (1992) Hyperinsulinemia: Possible Role in obesity-induced hypertension. Hypertension 19(suppl I):I-61-1-66
Landsberg L (1986) Diet, obesity and hypertension: An hypothesis involving insulin, the sympathetic nervous system, and adaptative thermogenesis. Q J Med 236:1081–1090
Levine RS, Hennekens CH, Jesse MJ (1994) Blood pressure in prospective population based cohort of newborn and infant twins. Br Med J 308:298–302
Lindquist TL, Beilin LJ, Knuiman MW (1997) Influence of lifestyle, coping, and job stress on blood pressure in men and women. Hypertension 29:1–7
Lund-Johansen P (1991) Twenty-year follow-up of hemodynamics in essential hypertension during rest and exercise. Hypertension 18(suppl III):III-54-III-61
Liischer TF, Seo B, Bühler F (1993) Potential role of endothelin in hypertension. Controversy on endothelin in hypertension. Hypertension 21:752–757
Luft FC, Weinberger MH, Grim CE (1982) Sodium sensitivity and resistance in normotensive humans. Am J Med 72:726–736
Masuo K, Mikami H, Ogihara T, Tuck ML (2000) Weight gain-induced blood pressure elevation. Hypertension 35:1135–1140
Morris AD, Petrie JR, Connell JMC (1994) Insulin and hypertension. J Hypertension 12:633–642
O’Donell CJ, Lindpaintner K, Larsson MG, Rao VS, Ordovas JM, Schaefer EJ et al (1998) Evidence for association and genetic linkage of the angiotensin-converting enzyme locus with hypertension and blood pressure in men but not in women in the Framingham Heart Study. Circulation 97:1766–1772
Oparil S, Carretero OA (2000) Essential hypertension. Part 1: Definition and etiology. Circulation 101:329–335
Regecova V, Kellerova E (1995) Effects of urban noise pollution on blood pressure and heart rate in preschool children. J Hypertension 13:405–412
Reisin E (1990) Sodium and obesity in the pathogenesis of hypertension. Am J Hypertension 3:164–167
Ribstein J, du Cailar G, Mimran A (1995) Combined renal effects of overweight and hypertension. Hypertension 26:610–615
Roccini AP (1992) Cardiovascular regulation in obesity-induced hypertension. Hypertension 19(suppl I):I-56-I-60
Scherrer U, Sartori C (1997) Insulin as a vascular and sympthoexcitatory hormone: implications for blood pressure regulation, insulin sensitivity, and cardiovascular morbidity. Circulation 96:4104–4113
Schiffrin EL (1995) Endothelin: potential role in hypertension and vascular hypertrophy. Hypertension 25:1135–1145
Schmidt S, van Hooft LMS, Grobbee DE, Ganten D, Ritz E (1993) Polymorphism of the angiotensin I converting enzyme gene is apparently not related to high blood pressure. Dutch Hypertension and Offspring Study. J Hypertension 11:345–348
Schmidt S, Sharma AM, Zilch O, Beige J, Walla-Friedel M, Ganten D, Distler A, Ritz E (1995) Association of M235T variant of the angiotensinogen gene with familial hypertension of early onset. Nephrol Dial Transplant 10:1145–1148
Schmidt S, Ganten D (1994) Genetics of primary hypertension. (Editorial Comment) Nephrol Dial Transplant 9:473–474
Sharma AM, Distler A, Luft FC (1994) Strategien zur Erforschung der Genetik des Bluthochdrucks. Dtsch med Wschr 119:742–746
Sinclair AM, Isles CG, Brown I, Cameron H, Murray GD, Robertson JWK (1987) Secondary hypertension in a blood pressure clinic. Arch Intern Med 147:1289–1293
Stamler R, Stamler J, Riedlinger WF, Algera G, Roberts RJ (1978) Weight and blood pressure: Findings in hypertension screening of one million Americans. JAMA 240:1607–1610
Stamler J, Rose G, Elliott P, Marmot M, Kesteloot H, Stamler R (1991) Findings of the international cooperative INTERSALT study. Hypertension 17(suppl I):I-9-I-15
Stamler J (1991) Implications of the INTERSALT study. Hypertension 17(suppl I):I-16-I-20
Stimpel M, Kaufmann W, Wambach G (1988) Atriales natriuretisches Peptid (ANP) bei essentieller Hypertonie: Humoraler Marker für Kochsalzsensitivität und hypertensive Herzkrankheit im klinisch-asymptomatischen Stadium? Z Kardiol 77(suppl 2):92–98
Vanhoutte PM (1993) Is endothelin involved in the pathogenesis of hypertension? Hypertension 21:747–751
Williams B (1994) Insulin resistance: the shape of things to come. Lancet 344:521–524
Williams GH (1994) Essential hypertension as an endocrine disease. Endocrinol Metab Clin N Am 23:429–444
Williams SM, Addy JH, Phillips JA, Dai M, Kpodonu J, Afful J, Jackson H, Joseph K, Eason F, Murray MM, Epperson P, Aduonum A, Wong L-J, Jose PA, Felder RA (2000) Combinations of variations in multiple genes are associated with hypertension. Hypertension 36:2–6
Woolfson RG, Poston L, De Wardener HE (1994) Digoxin-like inhibitors of active sodium transport and blood pressure: the current status. Kidney Int 46:297–309
Zanchetti A (1994) Hyperlipidaemia in the hypertensive patient. Am J Med. 96(suppl 6A): 3S–8S
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Stimpel, M. (2001). Primäre Hypertonie. In: Arterielle Hypertonie. Steinkopff, Heidelberg. https://doi.org/10.1007/978-3-642-57617-1_9
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