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Nonhuman Primate Herpesviruses:Importance for Xenotransplantation

  • Chapter
Xeno-transplantation

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 278))

Abstract

Herpesviruses are found throughout the animal kingdom. Members of this family share properties including a highly orchestrated system of transcription, destruction of the host cell by active viral replication and an ability to persist in the host in a latent form. Human herpesviruses have all been implicated in causing substantial disease after allotransplantation. Often transmission of these viruses has been through the donor organ or blood products. Analogous species of herpesviruses exist in nonhuman primates. Accordingly, concern regarding the risk of their transmission and disease exists with xenotransplant procedures. This chapter reviews herpesviruses of nonhuman primates and their potential implication for causing disease after xenotransplantation.

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  1. Division of Allergy, Immunology and Infectious Diseases, Children’s Hospital of Pittsburgh, University of Pittsburgh School of Medicine, 3705 Fifth Avenue, Pittsburgh, PA, 15213, USA

    M. G. Michaels

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  1. Department of Molecular and Experimental Medicine, The Scripps Research Institute, MEM 55, 10550 North Torrey Pines Road, La Jolla, CA, 92037, USA

    Daniel R. Salomon M.D.

  2. Division of Cellular and Gene Therapies Center for Biologics Evaluation and Research, U.S. Food and Drug Administration, FDA Building 29B, Room 2NN11 8800 Rockville Pike, HFM-530, Bethesda, MD, 20892, USA

    Carolyn Wilson M.D.

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Michaels, M.G. (2003). Nonhuman Primate Herpesviruses:Importance for Xenotransplantation. In: Salomon, D.R., Wilson, C. (eds) Xeno-transplantation. Current Topics in Microbiology and Immunology, vol 278. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-55541-1_4

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