Abstract
The role of filaggrin in ophthalmology has only been investigated recently. This chapter provides an overview of the literature on this area and outlines the authors’ detection of filaggrin on parts of the eye that have not yet been analyzed for filaggrin: the lens, the retinal pigment epithelium, and the ciliary body. The role of filaggrin proteins and filaggrin gene mutations in ophthalmological disorders has so far mainly been investigated in patients with skin diseases associated with filaggrin abnormality.
This chapter considers keratoconus, keratoconjunctivitis, and cataract, all associated with atopic dermatitis. There have been studies concerning filaggrin expression when the conjunctiva and cornea keratinize or become dysplastic. This chapter also discusses the findings of these studies with a view to improve the understanding of the role of filaggrin and will hopefully inspire further research.
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References
Jalbert I, Madigan MC, Shao M, Ng J, Cheng J, Wong D, et al. Assessing the human lid margin epithelium using impression cytology. Acta Ophthalmol. 2012;90(7):e547–52.
Nakamura T, Nishida K, Dota A, Matsuki M, Yamanishi K, Kinoshita S. Elevated expression of transglutaminase 1 and keratinization-related proteins in conjunctiva in severe ocular surface disease. Invest Ophthalmol Vis Sci. 2001;42(3):549–56.
Krenzer KL, Freddo TF. Cytokeratin expression in normal human bulbar conjunctiva obtained by impression cytology. Invest Ophthalmol Vis Sci. 1997;38(1):142–52.
Lund AS, Heegaard S, Prause JU, Toft PB, Skov L. Expression of filaggrin in normal and keratinized conjunctiva. Open Ophthalmol J. 2012;6:137–40.
Saika S, Minamide A, Tanaka T, Miyamoto T, Okada Y, Kawashima Y, et al. Expression of involucrin by ocular surface epithelia of patients with benign and malignant disorders. Curr Eye Res. 2000;21(5):877–85.
Spencer WH. Ophthalmic pathology, an atlas and textbook. 3rd ed. Philadelphia: W.B. Saunders; 1985.
Iwamoto S, Ebihara N, Hori K, Funaki T, Asada Y, Yokoi N, et al. Filaggrin mutations are not associated with chronic allergic keratoconjunctivitis. Br J Ophthalmol. 2012;96(9):1272–3.
Tong L, Corrales RM, Chen Z, Villarreal AL, De Paiva CS, Beuerman R, et al. Expression and regulation of cornified envelope proteins in human corneal epithelium. Invest Ophthalmol Vis Sci. 2006;47(5):1938–46.
Droitcourt C, Touboul D, Ged C, Ezzedine K, Cario-Andre M, de Verneuil H, et al. A prospective study of filaggrin null mutations in keratoconus patients with or without atopic disorders. Dermatology. 2011;222(4):336–41.
Li W, Chen YT, Hayashida Y, Blanco G, Kheirkah A, He H, et al. Down-regulation of Pax6 is associated with abnormal differentiation of corneal epithelial cells in severe ocular surface diseases. J Pathol. 2008;214(1):114–22.
Tanioka H, Yokoi N, Komuro A, Shimamoto T, Kawasaki S, Matsuda A, et al. Investigation of the corneal filament in filamentary keratitis. Invest Ophthalmol Vis Sci. 2009;50(8):3696–702.
Copeman PW. Eczema and keratoconus. Br Med J. 1965;2(5468):977–9.
Gasset AR, Hinson WA, Frias JL. Keratoconus and atopic diseases. Ann Ophthalmol. 1978;10(8):991–4.
Harrison RJ, Klouda PT, Easty DL, Manku M, Charles J, Stewart CM. Association between keratoconus and atopy. Br J Ophthalmol. 1989;73(10):816–22.
Ohmachi N, Sasabe T, Kojima M, Adachi J, Endo K, Fukuzumi T, et al. Eye complications in atopic dermatitis. Arerugi. 1994;43(7):796–9.
Bawazeer AM, Hodge WG, Lorimer B. Atopy and keratoconus: a multivariate analysis. Br J Ophthalmol. 2000;84(8):834–6.
Kaya V, Karakaya M, Utine CA, Albayrak S, Oge OF, Yilmaz OF. Evaluation of the corneal topographic characteristics of keratoconus with orbscan II in patients with and without atopy. Cornea. 2007;26(8):945–8.
Tomi M, Hosoya K. The role of blood-ocular barrier transporters in retinal drug disposition: an overview. Expert Opin Drug Metab Toxicol. 2010;6(9):1111–24.
Krogsaa B, Lund-Andersen H, Mehlsen J, Sestoft L. Blood-retinal barrier permeability versus diabetes duration and retinal morphology in insulin dependent diabetic patients. Acta Ophthalmol (Copenh). 1987;65(6):686–92.
Krogsaa B, Lund-Andersen H, Parving HH, Bjaeldager P. The blood-retinal barrier permeability in essential hypertension. Acta Ophthalmol (Copenh). 1983;61(4):541–4.
McLean WH, Palmer CN, Henderson J, Kabesch M, Weidinger S, Irvine AD. Filaggrin variants confer susceptibility to asthma. J Allergy Clin Immunol. 2008;121(5):1294–5; author reply 5–6.
Ying S, Meng Q, Corrigan CJ, Lee TH. Lack of filaggrin expression in the human bronchial mucosa. J Allergy Clin Immunol. 2006;118(6):1386–8.
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Bateman, A.S.L., Heegaard, S. (2014). The Eye and Filaggrin. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_31
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DOI: https://doi.org/10.1007/978-3-642-54379-1_31
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