Basic Science, Epidemiology, Clinical Aspects and Management

  • Jacob P. Thyssen
  • Howard I. Maibach

Table of contents

  1. Front Matter
    Pages i-xv
  2. Basic Science

    1. Front Matter
      Pages 1-1
    2. Jakob Mutanu Jungersted
      Pages 23-26
    3. Christian Vestergaard, Mette S. Deleuran
      Pages 27-36
    4. Charlotte M. Bonefeld, Morten M. Nielsen, Carsten Geisler
      Pages 37-47
    5. Jens-Michael Schröder, Britta Hansmann
      Pages 49-62
  3. Identification and Study Methods

    1. Front Matter
      Pages 63-63
    2. Kozo Nakai, Kozo Yoneda, Yasuo Kubota
      Pages 65-74
    3. Pal B. Szecsi, Michael Meldgaard
      Pages 103-116
  4. Epidemiology and Environmental Exposures

    1. Front Matter
      Pages 117-117
    2. Marten C. G. Winge, Maria Bradley
      Pages 119-128
    3. Ruhong Cheng, Ming Li, Hui Zhang, Zhirong Yao
      Pages 129-135
  5. Filaggrin and Atopic Disease

    1. Front Matter
      Pages 141-141
    2. Jennifer R. Heimall, Jonathan M. Spergel
      Pages 143-151

About this book


Filaggrin proteins are expressed in several human tissues, including the skin, oral mucosa, conjunctivae, esophagus, cervix, and testes.  While filaggrin guarantees both structural and functional normality of the human epidermis, its role in other tissues is largely unknown. Epidermal deficiency of filaggrin causes dry and scaly skin, but also strongly increases the risk of skin diseases, in particular ichthyosis vulgaris and atopic dermatitis. Importantly, the risk of related asthma, hay fever, and food allergy is also increased although filaggrin is not expressed in the airways and gastrointestinal tract.


Common FLG mutations, leading to reduced filaggrin expression, have mainly been identified in Europeans and Asians, reaching a prevalence of 5-10%. Even in the absence of atopic dermatitis, the skin of individuals with FLG mutations differs fundamentally from normal skin, for example by generating more vitamin D and allowing chemicals and allergens to more widely penetrate across the stratum corneum. 


This textbook provides comprehensive and detailed coverage of the effects of filaggrin and filaggrin gene (FLG) mutations in health and disease (cutaneous and non-cutaneous) and also discusses the basic science, epidemiology, management, and future research areas. It will be of value to scientists and clinicians from different specialties.


Clinical disease Disease patterns Ichthyosis vulgaris Treatment

Editors and affiliations

  • Jacob P. Thyssen
    • 1
  • Howard I. Maibach
    • 2
  1. 1.Department of Dermato-AllergologyNational Allergy Research Centre, Gentofte Hospital, University of CopenhagenHellerupDenmark
  2. 2.Department of DermatologyUniversity of CaliforniaSan FranciscoUSA

Bibliographic information

  • DOI
  • Copyright Information Springer-Verlag Berlin Heidelberg 2014
  • Publisher Name Springer, Berlin, Heidelberg
  • eBook Packages Medicine
  • Print ISBN 978-3-642-54378-4
  • Online ISBN 978-3-642-54379-1
  • About this book
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