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Atopic Dermatitis and Skin Cancer

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Filaggrin

Abstract

Filaggrin gene (FLG) mutation carriage increases risks of various types of aberrant human reactivity, including that of atopic dermatitis (AD); sometimes also the severity of the actual sensitivity is related. This chapter attempts to summarize the recent literature, although it is sparse, regarding the relation between FLG mutations, AD, and skin cancer. According to the results of large Scandinavian cohort studies, there is an increased risk of nonmelanoma skin cancer in patients with AD, in contrast to no increased risk of malignant melanoma. The epidemiological findings are discussed in relation to recently published interesting experiments using mice models. Actions should be taken to diminish inflammation and the carcinogenic effects of UV light as well as regular use of moisturizers. In the future, studies will continue to describe the molecular mechanisms involved, to provide insights for treatment improvements, and to find ways to reduce the patients’ risk for skin cancer.

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References

  1. Irvine AD, McLean WH, Leung DY. Filaggrin mutations associated with skin and allergic diseases. N Engl J Med. 2009;365(14):1315–27.

    Article  Google Scholar 

  2. Linos E, Swetter SM, Cockburn MG, Colditz GA, Clarke CA. Increasing burden of melanoma in the United States. J Invest Dermatol. 2009;129(7):1666–74.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  3. Demierre MF, Nathanson L. Chemoprevention of melanoma: an unexplored strategy. J Clin Oncol. 2003;21(1):158–65.

    Article  PubMed  Google Scholar 

  4. Klein-Szanto AJ, Barr RJ, Reiners Jr JJ, Mamrack MD. Filaggrin distribution in keratoacanthomas and squamous cell carcinoma. Arch Pathol Lab Med. 1984;108(11):888–90.

    CAS  PubMed  Google Scholar 

  5. Kvedar JC, Fewkes J, Baden HP. Immunologic detection of markers of keratinocyte differentiation. Its use in neoplastic and preneoplastic lesions of skin. Arch Pathol Lab Med. 1986;110(3):183–8.

    CAS  PubMed  Google Scholar 

  6. Hagströmer L, Ye W, Nyrén O, Emtestam L. Incidence of cancer among patients with atopic dermatitis. Arch Dermatol. 2005;141(9):1123–7.

    Article  PubMed  Google Scholar 

  7. Ming ME, Levy R, Hoffstad O, Filip J, Abrams BB, Fernandez C, et al. The lack of a relationship between atopic dermatitis and nonmelanoma skin cancers. J Am Acad Dermatol. 2004;50(3):357–62.

    Article  PubMed  Google Scholar 

  8. Olesen AB, Engholm G, Storm HH, Thestrup-Pedersen K. The risk of cancer among patients previously hospitalized for atopic dermatitis. J Invest Dermatol. 2005;125(3):445–9.

    Article  CAS  PubMed  Google Scholar 

  9. Jensen AO, Svaerke C, Kormendine Farkas D, Olesen AB, Kragballe K, Sorensen HT. Atopic dermatitis and risk of skin cancer: a Danish nationwide cohort study (1977-2006). Am J Clin Dermatol. 2012;13(1):29–36.

    Article  PubMed  Google Scholar 

  10. Synnerstad I, Fredrikson M, Ternesten-Bratel A, Rosdahl I. Low risk of melanoma in patients with atopic dermatitis. J Eur Acad Dermatol Venereol. 2008;22(12):1423–8.

    Article  CAS  PubMed  Google Scholar 

  11. Dyer RK, Weinstock MA, Cohen TS, Rizzo AE, Bingham SF. Predictors of basal cell carcinoma in high-risk patients in the VATTC (VA Topical Tretinoin Chemoprevention) trial. J Invest Dermatol. 2012;132(11):2544–51.

    Article  CAS  PubMed  Google Scholar 

  12. Arana A, Wentworth CE, Fernandez-Vidaurre C, Schlienger RG, Conde E, Arellano FM. Incidence of cancer in the general population and in patients with or without atopic dermatitis in the U.K. Br J Dermatol. 2010;163(5):1036–43.

    Article  CAS  PubMed  Google Scholar 

  13. El-Zein M, Parent ME, Ka K, Siemiatycki J, St-Pierre Y, Rousseau MC. History of asthma or eczema and cancer risk among men: a population-based case-control study in Montreal, Quebec, Canada. Ann Allergy Asthma Immunol. 2010;104(5):378–84.

    Article  PubMed  Google Scholar 

  14. Beral V, Evans S, Shaw H, Milton G. Cutaneous factors related to the risk of malignant melanoma. Br J Dermatol. 1983;109(2):165–72.

    Article  CAS  PubMed  Google Scholar 

  15. Wedgeworth E, Powell AM, Flohr C. Eczema and cancer risk: a critical appraisal and review of the literature. Br J Dermatol. 2011;165(3):457–62.

    Article  CAS  PubMed  Google Scholar 

  16. Kaae J, Thyssen JP, Johansen JD, Meldgaard M, Linneberg A, Allen M, Skov L. Filaggrin gene mutations and risk of basal cell carcinoma. Br J Dermatol. 2013;169(5):1162–4.

    Article  CAS  PubMed  Google Scholar 

  17. Cai SC, Chen H, Koh WP, Common JE, van Bever HP, McLean WH, et al. Filaggrin mutations are associated with recurrent skin infection in Singaporean Chinese patients with atopic dermatitis. Br J Dermatol. 2012;166(1):200–3.

    Article  CAS  PubMed  Google Scholar 

  18. Rajka G. Essential aspects of atopic dermatitis. Berlin/Heidelberg: Springer; 1989.

    Book  Google Scholar 

  19. Boffetta P, Ye W, Adami HO, Mucci LA, Nyren O. Risk of cancers of the lung, head and neck in patients hospitalized for alcoholism in Sweden. Br J Cancer. 2001;85(5):678–82.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  20. Reynolds P, Kaplan GA. Asthma and cancer. Am J Epidemiol. 1987;125(3):539–40.

    CAS  PubMed  Google Scholar 

  21. Robinette CD, Fraumeni Jr JF. Asthma and subsequent mortality in World War II veterans. J Chronic Dis. 1978;31(9–10):619–24.

    Article  CAS  PubMed  Google Scholar 

  22. Vesterinen E, Pukkala E, Timonen T, Aromaa A. Cancer incidence among 78,000 asthmatic patients. Int J Epidemiol. 1993;22(6):976–82.

    Article  CAS  PubMed  Google Scholar 

  23. Alderson M. Mortality from malignant disease in patients with asthma. Lancet. 1974;2(7895):1475–7.

    Article  CAS  PubMed  Google Scholar 

  24. Markowe HL, Bulpitt CJ, Shipley MJ, Rose G, Crombie DL, Fleming DM. Prognosis in adult asthma: a national study. BMJ (Clin Res Ed). 1987;295(6604):949–52.

    Article  CAS  Google Scholar 

  25. Mills PK, Beeson WL, Fraser GE, Phillips RL. Allergy and cancer: organ site-specific results from the Adventist Health Study. Am J Epidemiol. 1992;136(3):287–95.

    CAS  PubMed  Google Scholar 

  26. Sigurgeirsson B, Lindelöf B. Positive patch tests and cancer: an epidemiological study. Am J Contact Dermat. 1991;2:161–4.

    Article  Google Scholar 

  27. Lindelöf B, Sigurgeirsson B, Wahlgren CF, Eklund G. Chronic urticaria and cancer: an epidemiological study of 1155 patients. Br J Dermatol. 1990;123(4):453–6.

    Article  PubMed  Google Scholar 

  28. Thyssen JP, Linneberg A, Ross-Hansen K, Carlsen BC, Meldgaard M, Szecsi PB, et al. Filaggrin mutations are strongly associated with contact sensitization in individuals with dermatitis. Contact Dermatitis. 2013;68(5):273–6.

    Article  CAS  PubMed  Google Scholar 

  29. Mildner M, Jin J, Eckhart L, Kezic S, Gruber F, Barresi C, et al. Knockdown of filaggrin impairs diffusion barrier function and increases UV sensitivity in a human skin model. J Invest Dermatol. 2010;130(9):2286–94.

    Article  CAS  PubMed  Google Scholar 

  30. Devos M, Prawitt J, Staumont-Salle D, Hoste E, Fleury S, Bouchaert E, et al. Filaggrin degradation by caspase-14 is required for UVB photoprotection but does not influence allergic sensitization in a mouse model of atopic dermatitis. J Invest Dermatol. 2012;132(12):2857–60.

    Article  CAS  PubMed  Google Scholar 

  31. Denecker G, Hoste E, Gilbert B, Hochepied T, Ovaere P, Lippens S, et al. Caspase-14 protects against epidermal UVB photodamage and water loss. Nat Cell Biol. 2007;9(6):666–74.

    Article  CAS  PubMed  Google Scholar 

  32. Hoste E, Kemperman P, Devos M, Denecker G, Kezic S, Yau N, et al. Caspase-14 is required for filaggrin degradation to natural moisturizing factors in the skin. J Invest Dermatol. 2011;131(11):2233–41.

    Article  CAS  PubMed  Google Scholar 

  33. Uddin AN, Labuda I, Burns FJ. A novel mechanism of filaggrin induction and sunburn prevention by beta-damascenone in Skh-1 mice. Toxicol Appl Pharmacol. 2012;265(3):335–41.

    Article  CAS  PubMed  Google Scholar 

  34. Tennis P, Gelfand JM, Rothman KJ. Evaluation of cancer risk related to atopic dermatitis and use of topical calcineurin inhibitors. Br J Dermatol. 2011;165(3):465–73.

    Article  CAS  PubMed  Google Scholar 

  35. Jensen JM, Pfeiffer S, Witt M, Brautigam M, Neumann C, Weichenthal M, et al. Different effects of pimecrolimus and betamethasone on the skin barrier in patients with atopic dermatitis. J Allergy Clin Immunol. 2009;124(3 Suppl 2):R19–28.

    Article  CAS  PubMed  Google Scholar 

  36. Grether-Beck S, Felsner I, Brenden H, Kohne Z, Majora M, Marini A, et al. Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression. J Invest Dermatol. 2012;132(6):1561–72.

    Article  CAS  PubMed Central  PubMed  Google Scholar 

  37. Hagströmer L, Nyren M, Emtestam L. Do urea and sodium chloride together increase the efficacy of moisturisers for atopic dermatitis Skin? A comparative, double-blind and randomised study. Skin Pharmacol Appl Skin Physiol. 2001;14(1):27–33.

    Article  PubMed  Google Scholar 

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Author information

Authors and Affiliations

  1. Department of Dermatology, Karolinska Institutet, Stockholm, SE-141 86, Sweden

    Lennart Emtestam MD, PhD

  2. Department of Dermatology and Venereolgy, Södersjukhuset, Stockholm, SE-118 83, Sweden

    Lena Hagströmer MD, PhD & Karin Sartorius MD, PhD

  3. Section of Dermatology, Department of Clinical Science and Education, Karolinska Institutet, Södersjukhuset, Stockholm, Sweden

    Lena Hagströmer MD, PhD & Karin Sartorius MD, PhD

Authors
  1. Lennart Emtestam MD, PhD
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  2. Lena Hagströmer MD, PhD
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  3. Karin Sartorius MD, PhD
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Corresponding author

Correspondence to Lennart Emtestam MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  2. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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© 2014 Springer-Verlag Berlin Heidelberg

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Emtestam, L., Hagströmer, L., Sartorius, K. (2014). Atopic Dermatitis and Skin Cancer. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_28

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  • DOI: https://doi.org/10.1007/978-3-642-54379-1_28

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54378-4

  • Online ISBN: 978-3-642-54379-1

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