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Filaggrin in Psoriasis

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Filaggrin

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Abstract

Psoriasis is a chronic inflammatory skin disease of multifactorial origin. A number of psoriasis susceptibility loci are known, and some are shared with susceptibility for atopic dermatitis. This has led to speculation that filaggrin gene (FLG) mutations and changes in filaggrin expression may also be associated with psoriasis.

Several studies have looked at this association, but none have so far demonstrated a correlation between psoriasis and the two major FLG variants R501X and 2282del4. However, in Asian individuals with psoriasis, studies have demonstrated an association between psoriasis and the P478S polymorphism of the FLG as well as the p.K4022X FLG mutation. Immunohistological studies have shown that filaggrin expression is downregulated in psoriatic skin compared to non-lesional skin. The precise mechanisms are unknown; however, it is possible that elevated levels of psoriasis-associated tumor necrosis factor-α and interleukin-17 may play a role in downregulating filaggrin expression in lesional psoriatic skin.

In summary, there is little evidence to support a correlation between FLG mutations and psoriasis except perhaps in Asian individuals. Available data indicate that the decreased filaggrin expression in lesional psoriatic skin is due to a secondary downregulation of filaggrin expression independent of genetic mechanisms.

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Authors and Affiliations

  1. Department of Dermato-Allergology, Gentofte Hospital, Copenhagen University, Niels Andersens Vej 65, Hellerup, 2900, Denmark

    Peter Jensen MD, PhD & Lone Skov MD, PhD

Authors
  1. Peter Jensen MD, PhD
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  2. Lone Skov MD, PhD
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Correspondence to Peter Jensen MD, PhD .

Editor information

Editors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  2. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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© 2014 Springer-Verlag Berlin Heidelberg

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Jensen, P., Skov, L. (2014). Filaggrin in Psoriasis. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_26

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  • DOI: https://doi.org/10.1007/978-3-642-54379-1_26

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  • Online ISBN: 978-3-642-54379-1

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