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Function of Filaggrin and Its Metabolites

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Filaggrin

Abstract

Filaggrin is a major structural protein of the stratum corneum (SC), exerting a multitude of biochemical and biophysical functions that are crucial for the composition, structure, and barrier function of the SC. Deficiency of filaggrin has been associated with aberrant network of keratin filaments, disturbed synthesis and organization of the lipids, reduced levels of natural moisturizing factor, and enhanced surface pH. Recent studies identified a number of key biomolecules involved in filaggrin processing providing more insight in the mechanisms by which filaggrin deficiency might lead to skin barrier defect and disease. This chapter will summarize the current knowledge about the function of filaggrin, its precursor pro-filaggrin, and degradation products as well as the consequences of filaggrin deficiency for the skin barrier.

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Author information

Authors and Affiliations

  1. Coronel Institute of Occupational Health, Academic Medical Center, Meibergdreef 15, Amsterdam, 1105 AZ, The Netherlands

    Sanja Kezic PhD

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  1. Sanja Kezic PhD
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Correspondence to Sanja Kezic PhD .

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Editors and Affiliations

  1. Department of Dermato-Allergology, National Allergy Research Centre, Gentofte Hospital, University of Copenhagen, Hellerup, Denmark

    Jacob P. Thyssen

  2. Department of Dermatology, University of California, San Francisco, California, USA

    Howard I. Maibach

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Kezic, S. (2014). Function of Filaggrin and Its Metabolites. In: Thyssen, J., Maibach, H. (eds) Filaggrin. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-54379-1_1

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  • DOI: https://doi.org/10.1007/978-3-642-54379-1_1

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  • Publisher Name: Springer, Berlin, Heidelberg

  • Print ISBN: 978-3-642-54378-4

  • Online ISBN: 978-3-642-54379-1

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