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Kallikreins in Glandular Tissues

  • Chapter
Bradykinin, Kallidin and Kallikrein

Abstract

The kallikreins have been defined as endogenous enzymes which rapidly and specifically liberate a kinin from plasma (Appendix on Nomenclature). Perhaps more comprehensively they might be defined as those proteolytic enzymes of animal origin which release a kinin from kininogen but, as far as is known, do not readily cleave peptide bonds in other proteins. The term kininogenase is a general one which has been applied to any enzyme that liberates a kinin from an inactive protein substrate. However, not all authors agree with this terminology, preferring to call all these enzymes kininogenins since to them the former expression implies the destruction of kininogen and the latter the formation (genesis) of active kinins (Rocha e Silva, 1962, 1963, 1965, and personal communication). For the purpose of this chapter the term kallikrein will be restricted to mammalian and avian kallikreins and will not include those enzymes found in snake venom, which may also be kallikreins (Iwanaga et al., 1965).

Supported in part by Fundacao de Amparo a Pesquisa do Estado de Sao Paulo. Grant No. 68/638; National Institutes of Health, Special Fellowship, Grant No. 1 FO3 AM 42717-01.

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  1. Marion E. Webster
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  1. Department of Pharmacology, University of Oklahoma Medical Center, Oklahoma City, Oklahoma, USA

    Ervin G. Erdös

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Webster, M.E. (1970). Kallikreins in Glandular Tissues. In: Erdös, E.G., Wilde, A.F. (eds) Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 25 / 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46222-1_7

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