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Bradykinin, Kallidin and Kallikrein

  • Book
  • © 1970

Overview

Editors:
  1. Ervin G. Erdös

    1. Department of Pharmacology, University of Oklahoma Medical Center, Oklahoma City, USA

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    You can also search for this editor in PubMed   Google Scholar

  2. Anne F. Wilde
    View editor publications

    You can also search for this editor in PubMed   Google Scholar

Part of the book series: Handbook of Experimental Pharmacology (HEP, volume 25 / 2)

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Table of contents (35 chapters)

  1. Front Matter

    Pages I-XIX
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  3. Methods Used in Kinin Research

    1. The Kinins: Methods of Chemical Synthesis

      • J. M. Stewart
      Pages 14-20

    2. Purification of Mammalian Kallikreins, Kininogens, and Kinins

      • Jack V. Pierce
      Pages 21-51

    3. Assay Methods in the Kinin System

      • Ivar Trautschold
      Pages 52-81

  4. Kininogenases

    1. Plasma Kininogenases and Their Activators

      • V. Eisen, W. Vogt
      Pages 82-130

    2. Kallikreins in Glandular Tissues

      • Marion E. Webster
      Pages 131-155

    3. Proteolytic Enzymes as Kininogenases

      • J. L. Prado
      Pages 156-192

    4. Snake Venoms

      • Tomoji Suzuki, Sadaaki Iwanaga
      Pages 193-212

    5. Kallikrein Inhibitors

      • Rosmarie Vogel, Eugen Werle
      Pages 213-249

  5. Kininogens

    1. Kininogens

      • E. Habermann
      Pages 250-288

  6. Kininases

    1. Kininases

      • E. G. Erdös, H. Y. T. Yang
      Pages 289-323

  7. Kinins

    1. Physiological and Pharmacological Actions

      1. Structure-Activity Relationships of Kinins
        • E. Schröder
        Pages 324-350
      2. Effect of Kallikrein on the Cardiovascular System
        • Gerhard A. Brecher, Günther F. Brobmann
        Pages 351-361
      3. The Effect of the Kinins on the Cardiovascular System
        • F. J. Haddy, T. E. Emerson Jr., J. B. Scott, R. M. Daugherty Jr.
        Pages 362-384
      4. Effects of Bradykinin on the Kidney and Gastrointestinal Organs
        • Eugene D. Jacobson
        Pages 385-388
      5. The Physiological Role of Glandular Kallikreins
        • S. M. Hilton
        Pages 389-399
      6. Vasodilatation in the Submaxillary Gland of the Cat, Rabbit, and Sheep
        • M. Schachter
        Pages 400-408
      7. Kinins and Ventilation of the Lungs
        • H. O. J. Collier
        Pages 409-420
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Keywords

About this book

Bradykinin is frequently referred to as an elusive substance; the editor of a comprehensive volume dealing with kinins thus has a difficult task. The com­ plexity of the issues calls for a large number of contributors who approach the topics from the various angles that are dictated by the sometimes divergent views of the individuals. The editor saw no reason to prescribe the mode of presentation, which was left to the authors and accounts for the variety of approaches. Contributors from nine countries were asked to participate in the volume. The chapters were organized to present, first, the history of the discoveries and methods of approach to kinin research. Then follows a discussion of the enzymes that release kinins, their substrates, and other enzymes that inactivate the peptides. If the release of kinin is important, then the inhibition of the releasing enzymes is of obvious interest and is described. Since the measurement of kinin­ ogen levels in blood has been frequently used as an indicator of kinin liberation, in addition to a separate chapter, kininogens are also mentioned where the functions of kinins are discussed. The conclusions drawn from establishing structure-action relationships for many analogs and the actions of kinins are indicated and summarized.

Editors and Affiliations

  • Department of Pharmacology, University of Oklahoma Medical Center, Oklahoma City, USA

    Ervin G. Erdös

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