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Kinins in Inflammation and Tissue Injury

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Bradykinin, Kallidin and Kallikrein

Abstract

The four cardinal signs of inflammation—vasodilatation, increased vascular permeability, pain, and accumulation of leukocytes—appear after all kinds of tissue injuries; this has led to the idea that these actions may be mediated by a single chemical substance.

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References

  1. Aarsen, P. N.: The influence of analgesic-antipyretic drugs on the responses of guinea pig lungs to bradykinin Brit. J. Pharmacol. 27, 196 (1966).

    CAS  Google Scholar 

  2. Allwoon, M. J., Lewis, G. P.: Bradykinin and forearm blood flow. J. Physiol. (Lond.) 170, 571 (1964).

    Google Scholar 

  3. Antopol, W., Ciiryssanthou, C.: Possible significance of bradykinin in Shwartzman and other phenomena. Ann. N.Y. Acad. Sci. 104, 346 (1963).

    PubMed  CAS  Google Scholar 

  4. Antopol, W., Ciiryssanthou, C.: Shwartzman phenomenon mechanism: Newer concepts. Arch. Path. 78, 313 (1964).

    PubMed  CAS  Google Scholar 

  5. Armstrong, D., Jepson, J. B., Keele, C. A., Stewart, J. W.: Pain producing substance in human inflammatory exudates and plasma. J. Physiol. (Lond.) 135, 350 (1957).

    CAS  Google Scholar 

  6. Bauer, G., Gmeiner, R., Konzett, H.: Zum Antagonismus von Antiphlogistica gegenĂĽber der Wirkung von Kininen auf den Druck in der Arteria pulmonalis von Meerschweinchen. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 251, 182 (1965).

    Google Scholar 

  7. Becker, E. L., Mota, I., Wong, D.: Inhibition by antihistamines of the vascular permeability increase induced by bradykinin. Brit. J. Pharmacol. 34, 330 (1968).

    CAS  Google Scholar 

  8. Beloff, A., Peters, R. A.: Observations upon thermal burns: The influence of moderate temperature burns upon a proteinase of skin. J. Physiol. (Lond.) 103, 461 (1945).

    CAS  Google Scholar 

  9. Bhoola, K. D., Collier, H. O. J., Schachter, M., Shorley, P. G.: Action of some peptides on bronchial muscle. Brit. J. Pharmacol. 19, 190 (1962).

    PubMed  CAS  Google Scholar 

  10. Burch, G. E., Pasquale, N. P. DE: Bradykinin, digital blood flow on the arterio venous anastomoses. Circulat. Res. 10, 105 (1962).

    PubMed  CAS  Google Scholar 

  11. Carpi, A., Klupp, H., Konzett, H.: Über die Bradykinin-Wirkung am Herz-LungenPräparat des Meerschweinchens. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 243, 356 (1962).

    Google Scholar 

  12. Cline, M. J., Melmon, K. L.: Plasma kinins and cortisol: A possible explanation of the anti-inflammatory action of cortisol. Science 153, 1135 (1966).

    PubMed  CAS  Google Scholar 

  13. Coffman, J. D.: The effect of aspirin on pain and hand blood flow responses to intra-arterial injection of bradykinin in man. Clin. Pharmacol. Ther. 7, 26 (1966).

    PubMed  CAS  Google Scholar 

  14. Collier, H. O. J.: The action and antagonism of kinins on bronchioles. Ann. N.Y. Acad. Sci. 104, 290 (1963).

    PubMed  CAS  Google Scholar 

  15. Collier, H. O. J., Shorley, P. G.: Analgesic antipyretic drugs as antagonists of bradykinin Brit. J. Pharmacol. 15, 601 (1960).

    CAS  Google Scholar 

  16. Collier, H. O. J., Shorley, P. G.: Antagonism by mefenamic and flufenamic acids of the broncho-constrictor action of kinins in the guinea pig. Brit. J. Pharmacol. 20, 345 (1963).

    PubMed  CAS  Google Scholar 

  17. Collier, H. O. J., Holgate, J. A., Schachter, M., Shorley, P. G.: The bronchoconstrictor action of bradykinin in the guinea pig. Brit. J. Pharmacol. 15, 290 (1960).

    PubMed  CAS  Google Scholar 

  18. Collier, H. O. J., Hammond, A. R., Horwood-Barrett, S., Schneider, C.: Rapid induction by acetylcholine, bradykinin and potassium of a nociceptive response in mice and its selective antagonism by aspirin. Nature (Lond.) 204, 1316 (1964).

    CAS  Google Scholar 

  19. Concloli, M., Mariani, L., Villani, R.: Influsso di farmaci antibradichininici sulle variazioni del circolo cortico-piale nello shock anafilatico della cavia. Atti Accad. med. lombarda 17, 242 (1962).

    Google Scholar 

  20. Cullumbine, H., Rydon, H. N.: A study of the formation properties and partial purification of leukotaxin. Brit. J. exp. Path. 27, 33 (1946).

    PubMed  CAS  Google Scholar 

  21. Davies, G. E., Holman, G., Johnston, T. P., Lowe, J. S.: Studies on kallikrein: Failure of some anti-inflammatory drugs to affect release of kinins. Brit. J. Pharmacol. 28, 212 (1966).

    PubMed  CAS  Google Scholar 

  22. Duthie, E. S., Chain, E. A.: Polypeptides responsible for some of the phenomena of acute inflammation. Brit. J. exp. Path. 20, 417 (1939).

    CAS  Google Scholar 

  23. Edery, H., Lewis, G. P.: Inhibition of plasma kininase activity at slightly acid pH. Brit. J. Pharmacol. 19, 299 (1962).

    PubMed  CAS  Google Scholar 

  24. Edery, H., Lewis, G. P.: Kinin-forming activity and histamine in lymph after tissue injury. J. Physiol. (Lond.) 169, 568 (1963).

    CAS  Google Scholar 

  25. Eisen, V.: Effect of hexadimethrine bromide on plasma kinin formation hydrolysis of p-tosyl-L-arginine methyl ester and fibrinolysis. Brit. J. Pharmacol. 22, 87 (1964).

    PubMed  CAS  Google Scholar 

  26. Eisen, V.: Urates and kinin formation in synovial fluid. Proc. roy. Soc. Med. 59 (4), 302 (1966).

    CAS  Google Scholar 

  27. Eisen, V., Greenbaum, L., Lewis, G. P.: Kinins and anti-inflammatory steroids. Brit. J. Pharmacol. 34, 169 (1968).

    CAS  Google Scholar 

  28. Elliott, D. F., Lewis, G. P.: Methionyl-lysyl-bradykinin, a new kinin from ox blood. Biochem. J. 95, 437 (1965).

    PubMed  CAS  Google Scholar 

  29. Elliott, D. F., Horton, E. W., Lewis, G. P.: Actions of pure bradykinin. J. Physiol. (Lond.) 153, 437 (1960).

    Google Scholar 

  30. Emele, J. F., Shanaman, J.: A method for measuring analgesia. Proc. Soc. exp. Biol. (N.Y.) 114, 680 (1963).

    CAS  Google Scholar 

  31. Erdös, E. G.: Effect of nonsteroidal anti-inflammatory drugs in endotoxin shock. Biochem. Fharmacol. Suppl., p. 283 (1968).

    Google Scholar 

  32. Erdös, E. G., Renfrew, A. G., Sloane, E. M., Wohler, J. R.: Enzymatic studies on bradykinin and similar peptides. Ann. N.Y. Acad. Sci. 104, 222 (1963).

    Google Scholar 

  33. Feldberg, W.: Action of histamine on blood vessels of the rabbit. J. Physiol. (Lond.) 63, 211 (1927).

    CAS  Google Scholar 

  34. Fox, R. H., Goldsmith, R., Kidd, D. J., Lewis, G. P.: Bradykinin as a vasodilator in man. J. Physiol. (Lond.) 157, 589 (1961).

    CAS  Google Scholar 

  35. Frey, E. K., Kraut, H., Werle, E.: Kallikrein. Padutin. Stuttgart: Enke 1950.

    Google Scholar 

  36. Gjuris, V., Heicke, B., Westermann, E.: Apnoe nach Bradykinin und Kallidin. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 248, 540 (1964a).

    CAS  Google Scholar 

  37. Gjuris, V., Heicke, B., Westermann, E.: Ăśber die Stimulierung der Atmung durch Bradykinin und Kallidin. Naunyn- Schmiedebergs Arch. exp. Path. Pharmak. 247, 429 (1964b).

    CAS  Google Scholar 

  38. Goodwin, L. G., Richards, W. H. G.: Pharmacologically active peptides in the blood and urine of animals infected with Babesia rodhaini and other pathogenic organisms. Brit. J. Pharmacol. 15, 152 (1960).

    PubMed  CAS  Google Scholar 

  39. Jones, C. R., Richards, W. H. G., Kohn, J.: Pharmacologically active substances in the urine of burned patients. Brit. J. exp. Path. 44, 551 (1963).

    PubMed  Google Scholar 

  40. Graham, R. C., Erbert, R. H., Ratnoff, O. D., Moses, J. M.: Pathogenesis of inflammation. II. In vivo observations of the inflammatory effects of activated Hageman factor and bradykinin. J. exp. Med. 121, 807 (1965).

    Google Scholar 

  41. Greeff, K., Moog, E.: Vergleichende Untersuchungen über die bronchoconstrictorische und gefäßconstrictorische Wirkung des Bradykinins, Histamins und Serotonins an isolierten Lungenpräparaten. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 248, 204 (1964).

    CAS  Google Scholar 

  42. Greenbaum, L. M., Yamafuji, K.: The role of cathepsins in the activation of plasma kinins. In: Hypotensive peptides, p. 252, ed. by E. G. Erdös, N. Back, and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  43. Guth, P. S., Cano, G., Jaramillo, J.: The effect of bradykinin on vascular smooth muscle. Ann. N.Y. Acad. Sci. 104, 69 (1963).

    PubMed  CAS  Google Scholar 

  44. Guth, P. S., Bobbin, R., Cano, G., Amaro, J.: Vasoconstriction induced by bradykinin in the rabbit ear. In: Hypotensive peptides, p. 396, ed. by E. G. Erdös, N. Back, and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  45. Guy, J. L., Lee, K. H., Leung, P. M. B., Lim, R. K. S.: Plasma salicylate levels associated with analgesia to bradykinin-evoked pain in dog and man. Pharmacologist 8, 207 (1966).

    Google Scholar 

  46. Guzman, F., Braun, C., Lim, R. K. S.: Visceral pain and the pseudoaffective response to intra-arterial injection of bradykinin and other algesic agents. Arch. int. Pharmacodyn. 136, 353 (1962).

    CAS  Google Scholar 

  47. Potter, G. D., Rodgers, D. W.: Narcotic and nonnarcotic analgesics which block visceral pain evoked by intra-arterial injection of bradykinin and other algesic agents. Arch. in Pharmacodyn. 149, 571 (1964).

    Google Scholar 

  48. Hashimoto, K., Kumakura, S., Taira, N.: Vascular reflex responses induced by intra-arterial injection of azaazepinophenothiazine, andromedotoxin, veratridine, bradykinin and kallikrein and blocking action of sodium salicylate. Jap. J. Physiol. 14, 299 (1964).

    CAS  Google Scholar 

  49. Hebborn, P., Shaw, B.: The action of sodium salicylate and aspirin on some kallikrein systems. Brit. J. Pharmacol. 20, 254 (1963).

    PubMed  CAS  Google Scholar 

  50. Herxheimer, A., Schachter, M.: Wheal and flare in human skin produced by histamine and other substances. J. Physiol. (Lond.) 145, 34P (1959).

    Google Scholar 

  51. Hilton, S. M., Lewis, G. P.: Functional vasodilatation in the submandibular salivary gland. Brit. med. Bull. 13, 189 (1957).

    CAS  Google Scholar 

  52. Holdstock, D. J., Mathias, A. P., Schachter, M.: A comparative study of kinin, kallidin, and bradykinin. Brit. J. Pharmacol. 12, 149 (1957).

    PubMed  CAS  Google Scholar 

  53. Holton, F. A., Holton, P.: Vasodilator activity of spinal roots. J. Physiol. (Lond.) 118, 310 (1952).

    CAS  Google Scholar 

  54. Hopsu-Havu, V. K., Mäkinen, K. K., Glenner, G. G.: Formation of bradykinin from kallidin-10 by aminopeptidase B. Nature (Lond.) 212, 1271 (1966).

    CAS  Google Scholar 

  55. Horton, E. W.: The role of bradykinin in the peripheral nervous system. Ann. N.Y. Acad. Sci. 104, 250 (1963).

    PubMed  CAS  Google Scholar 

  56. Ishioka, T., Matsumura, T., Takeuchi, K., Yagishita, M., Hazami, H.: Studies on venoconstriction effect of venoactive substances on saphenous vein of rabbit and antagonists of venoconstriction induced by bradykinin. Ochanomizu med. J. 13, 298 (1966).

    Google Scholar 

  57. Jacobsen, S., Waaler, B. A.: The effect of scalding on the content of kininogen and kininase in limb lymph. Brit. J. Pharmacol. 27, 222 (1966).

    PubMed  CAS  Google Scholar 

  58. Jaques, R., Huber, G., Neipp, L., Rossi, A., Schar, B., Meier, R.: Ein chemisch und pharmakologisch neuartiger Antagonist von pathophysiologisch bedeutsamen Aminen, Kininen und kininbildenden Faktoren. Experientia (Basel) 23, 149 (1967).

    CAS  Google Scholar 

  59. Jasani, M. K., Katori, M., Lewis, G. P.: Intracellular enzymes and kinin enzymes in synovial fluid in joint diseases: Origin and relation to disease category. Ann. rheum. Dis. 28, 497 (1969).

    PubMed  CAS  Google Scholar 

  60. Keele, C. A., Armstrong, D.: Substances producing pain and itch, p. 399. Baltimore: Williams and Wilkins 1964.

    Google Scholar 

  61. Kellermeyer, R. W., Breckenridge, R. T.: The inflammatory process in acute gouty arthritis. I. Activation of Hageman factor by sodium urate crystals. J. Lab. clin. Med. 65, 307 (1965).

    CAS  Google Scholar 

  62. Klupp, H., Konzett, H.: Der EinfluĂź von Bradykinin und Kallidin auf den Druck in der Arteria pulmonalis. Naunyn-Schmiedebergs Arch. exp. Path. Pharmak. 249, 479 (1965).

    CAS  Google Scholar 

  63. Konzett, H., StĂĽrmer, E.: Biological activity of synthetic polypeptides with bradykinin-like properties. Brit. J. Pharmacol. 15, 544 (1960).

    PubMed  CAS  Google Scholar 

  64. Krogh, A.: The anatomy and physiology of capillaries, 2nd ed., p. 238. Newhaven: Yale University Press; London: Oxford University Press 1929.

    Google Scholar 

  65. Lecomte, J.: Bradykinin and anaphylactic shock in rabbits. Acta allerg. (Kbh.) 14, 408 (1959).

    CAS  Google Scholar 

  66. Lecomte, J.: Antagonism between synthetic bradykinin and phenylbutazone in the rabbit. C. R. Soc. Biol. (Paris) 154, 2389 (1960).

    CAS  Google Scholar 

  67. Lecomte, J.: Antagonism between synthetic bradykinin and sodium salicylate in the rat. C. R. Soc. Biol. (Paris) 156, 1932 (1962).

    CAS  Google Scholar 

  68. Lecomte, J., Troquet, J.: Antagonism between bradykinin and phenylbutazone in the rabbit. C. R. Soc. Biol. (Paris) 154, 1115 (1960).

    CAS  Google Scholar 

  69. Leme, J. Garcia, Rocha E., Silva, M.: Competitive and non-competitive inhibition of bradykinin on the guinea pig ileum. Brit. J. Pharmacol. 25, 50 (1965).

    CAS  Google Scholar 

  70. Lewis, G. P.: Bradykinin-biochemistry, pharmacology and its physiological role in controlling local blood flow. Sci. Basis Med. 14, 242 (1962).

    Google Scholar 

  71. Lewis, G. P.: Kinin antagonism and kinin formation. In: Salicylates, p.134, ed. by A. ST.J. Dixon, B. K. Martin, M. J. H. Smith and P. H. N. Woods. London: Churchill 1963a.

    Google Scholar 

  72. Lewis, G. P.: Discussions; Kinins and Erythema. In: Salicylates, p. 134, ed. by A. ST. J. Dixon, B. K. Martin, M. J. H. Smith, P. H. N. Wood. London: 1963b.

    Google Scholar 

  73. Lewis, G. P.: Plasma kinin and other vasoactive compounds in acute inflammation. Ann. N.Y. Acad. Sci. 116, 847 (1964).

    PubMed  CAS  Google Scholar 

  74. Lewis, G. P., Winsey, N. J. P.: The action of pharmacologically active substances on the flow and composition of cat hind limb lymph. Brit. J. Pharmacol. 35 (1969).

    Google Scholar 

  75. Lewis, T.: Blood vessels in human skin and their responses, p. 322. London: Shaw and Son Ltd. 1927.

    Google Scholar 

  76. Lmi, R. K. S., Guzman, F., Rodgers, D. W., Goto, K. Braun, C., Dickerson, C. D., Engle, R. J.: Site of action of narcotic and nonnarcotic analgesics determined by blocking bradykinin evoked visceral pain. Arch. in Pharmacodyn. 152, 25 (1964).

    Google Scholar 

  77. Lisin, N., Leclercq, R., Cauwenberge, H. V.: L’Oedème and la bradykinine et son inhibition. Rev. Rhum. 30, 790 (1963).

    PubMed  CAS  Google Scholar 

  78. Majno, G., Gilmore, V., Leventhal, M.: On the mechanism of vascular leakage caused by histamine-type mediators. Circulat. Res. 21, 833 (1967).

    PubMed  CAS  Google Scholar 

  79. Marian, L.: Farmaci antagonist della bradichinina. Boll. Soc. ital. Biol. sper. 37, No 24 (1961).

    Google Scholar 

  80. Martelli, E. A.: Antagonism of anti-inflammatory drugs on bradykinin-induced increase of capillary permeability. J. Pharm. Pharmacol. 19, 617 (1967).

    PubMed  CAS  Google Scholar 

  81. Melmon, K. L., Cline, M. J.: Interaction of plasma kinins and granulocytes. Nature (Lond.) 213, 90 (1967).

    CAS  Google Scholar 

  82. Melmon, K. L., Webster, M. E., Goldfinger, S. E., Seegmiller, J. E.: The presence of a kinin in inflammatory synovial effusion from arthritides of varying etiologies. Arthr. and Rheum. 10, 13 (1967).

    CAS  Google Scholar 

  83. Menkin, V.: Studies on inflammation. XII. Mechanism of increased capillary permeability. A critique of the histamine hypothesis. J. exp. Med. 64, 485 (1936).

    PubMed  CAS  Google Scholar 

  84. Menkin, V.: Dynamics of inflammation. New York: McMillan 1940.

    Google Scholar 

  85. Miles, A. A.: Large molecular substances as mediators of the inflammatory reaction. Ann. N.Y. Acad. Sci. 116, 855 (1964).

    PubMed  CAS  Google Scholar 

  86. Northover, B. J., Subramanian, G.: Analgesic-antipyretic drugs as inhibitors of kallikrein. Brit. J. Pharmacol. 17, 107 (1961).

    PubMed  CAS  Google Scholar 

  87. Oyvin, I. A., Uklonskaya, L. I., Garoniux, P. J.: The participation of kinins in the pathogenesis of early disturbances in skin capillary permeability in local beta-ray irradiation. Experientia (Basel) 23, 555 (1967).

    CAS  Google Scholar 

  88. Phelps, P., Prokop, D. J., Mccarty, D. J.: Crystal induced inflammation in canine joints. III. Evidence against bradykinin as a mediator of inflammation. J. Lab. clin. Med. 68, 433 (1966).

    PubMed  CAS  Google Scholar 

  89. Reizen, H.: Methixene, a non-competitive antagonist of bradykinin. J. Pharm. Pharmacol. 18, 688 (1966).

    Google Scholar 

  90. Reizen, H., Bettrrk, E.: N-(3-benzylthio-2,6-dichlorophenyl)anthramyl acid (ASD 30): A non- competitive antagonist of bradykinin. J. Pharm. Pharmacol. 20, 474 (1968).

    Google Scholar 

  91. Rocha E., Silva, M., Rosenthal, S. R.: Release of pharmacologically active substances from the rat skin in vivo following thermal injury. J. Pharmacol. exp. Ther. 132, 110 (1961).

    Google Scholar 

  92. Rocha E., Antonio, A.: Release of bradykinin and the mechanism of production of a thermic edema (45° C) in the rat paw. Med. exp. (Basel) 3, 371 (1960).

    Google Scholar 

  93. Rocha E., Leme, Garcia, J.: Antagonists of bradykinin Med. exp. (Basel) 8, 287 (1963).

    Google Scholar 

  94. Rocha E., Leme, Garcia, J.: Studies on the antagonists of bradykinin Proceedings of an Internat. Symposium on Non-Steroidal Anti-Inflammatory Drugs, Congr. No 82, Milan, Sept. 1964.

    Google Scholar 

  95. Rosa, G., Buxiolo, E., Valle, J. R.: Homochlorcyclizine as antagonist against chemical mediators and plasmakinins Acta physiol. lat.-amer. 12, 408, (1962).

    CAS  Google Scholar 

  96. Schade, H.: Physical pathology of inflammation. Munch. med. Wschr. 71, 1 (1924).

    Google Scholar 

  97. Shidsamoto, T., Numano, F., Fumra, T.: Atherosclerosis-inhibiting effect of an antibradykinin agent, pyridinolcarbamate. Amer. Heart J. 71, 216 (1966a).

    Google Scholar 

  98. Shidsamoto, T., Numano, F., Ismoka, T., Atsumi, T.: Treatment of experimental and human atherosclerosis with bradykinin antagonist, pyridinolcarbamate. In: Hypotensive peptides, p. 520, ed. by E. G. Erdös, N. Back, and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966b.

    Google Scholar 

  99. Sicuteri, F.: Indomethacin as a new vasoconstrictor and therapeutic agent in migraine. In Ref. 93, p. 335.

    Google Scholar 

  100. Skybing, A., Singer, A., Tornya, P.: Treatment of acute pancreatitis with Trasylol; Report of a controlled therapeutic trial. Brit. med. J. 2, 627 (1965).

    Google Scholar 

  101. Spector, W. G.: The role of some higher peptides in inflammation. J. Path. Bact. 63, 93 (1951).

    PubMed  CAS  Google Scholar 

  102. Spector, W. G., Willoughby, D. A.: Anti-inflammatory effects of salicylates in the rat. In: Salicylates, p. 141, ed. by A. ST. J. Dixon, B. K. Martin, M. J. H. Smith and P. H. N. Wood. London: J. and A. Churchill Ltd. 1963.

    Google Scholar 

  103. Starr, M. S., West, G. B.: Bradykinin and oedema formation in heated paws of rats. Brit. J. Pharmacol. 31, 178 (1967).

    PubMed  CAS  Google Scholar 

  104. Stewart, J. M., Woolley, D. W.: The search for peptides with specific antibradykinin activity. In: Hypotensive peptides, p. 23, ed. by E. G. Erdös, N. Back, and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  105. Stewart, J. M., Woolley, D. W.: Bradykinin analogues. In: Bradykinin and related peptides, p. 7, ed. by M. Rocha E., Srlva and H. A. Rothschild Sao Paulo 1967.

    Google Scholar 

  106. Stresemann, E.: Die Wirkung von Bradykinin-Aerosol auf die Atmung des Menschen und des Meerschweinchens und der EinfluĂź verschiedener Substanzen auf den experimentellen Bradykinin-Bronchospasmus. Acta allerg. (Kbh.) 18, 235 (1963).

    CAS  Google Scholar 

  107. Stürmer, E.: The influence of intra-arterial infusions of synthetic bradykinin on flow and composition of lymph in dogs. In: Hypotensive peptides, p. 368, ed. by E. G. Erdös, N. Back, and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  108. Tella, A., Macgrarrh, B. G.: Bradykinin in P. knowlesi injection. Trans. roy. Soc. trop. Med. Hyg. 56, 6 (1962).

    Google Scholar 

  109. Trautschold, I.: In: Das Kallikrein-Kinin-System und seine Inhibitoren, p. 223, ed. by E. K. Frey, H. Kraut, E. Werle, R. Vogel, G. Zickgraf-RĂĽdel, and I. Trautschold. Stuttgart: F. Enke 1968.

    Google Scholar 

  110. TĂĽbkeb, K., Mager, B. K.: The antagonist effect of noramidopyrine methanesulfonate on some pharmacological actions of the synthetic bradykinin Arzneimittel-Forsch. 14, 1318 (1964).

    Google Scholar 

  111. Ungar, G.: Release of proteolytic enzyme in anaphylactic and peptone shock in vitro. Lancet 1947 I, 708.

    Google Scholar 

  112. Vogel, G., Wendt, B., Ströcker, H.: Versuche zur Wirkung von Pharmaka auf die Plasma-Lymph-Schranke von Ratten nach Einstellen eines Zustandes gesteigerter Kapillarpermeabilität. Arzneimittel-Forsch. 17, 454 (1967).

    CAS  Google Scholar 

  113. Walters, M. N., Wmrouanay, D. A.: The effect of tissue extracts on vascular permeability and leucocyte emigration. J. Path. Bact. 89, 255 (1965a).

    PubMed  CAS  Google Scholar 

  114. Walters, M. N., Wmrouanay, D. A.: Indomethacin, a new anti-inflammatory drug; its potential use as a laboratory tool. J. Path. Bact. 90, 641 (1965b).

    PubMed  CAS  Google Scholar 

  115. Webster, M. E., Pierce, J. V.: The nature of the kallidins released from human plasma by kallikreins and other enzymes. Ann. N.Y. Acad. Sci. 104, 91 (1963).

    PubMed  CAS  Google Scholar 

  116. Werle, E.: Ober die Inaktivierung des Kallikreins II Mitt Biochem. Z. 278, 291 (1934).

    Google Scholar 

  117. Zacharlae, H., Malmquist, J., Oates, J. A., Pettinger, W.: Studies on the mechanism of kinin formation in inflammation. J. Physiol. (Lond.) 190, 81 (1967).

    Google Scholar 

  118. Zweifach, B. W.: Microcirculatory effects of polypeptides. In: Hypotensive peptides, p. 451, ed. by E. G. Erdös, N. Back, and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

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Lewis, G.P. (1970). Kinins in Inflammation and Tissue Injury. In: Erdös, E.G., Wilde, A.F. (eds) Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 25 / 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46222-1_24

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