Abstract
The four cardinal signs of inflammation—vasodilatation, increased vascular permeability, pain, and accumulation of leukocytes—appear after all kinds of tissue injuries; this has led to the idea that these actions may be mediated by a single chemical substance.
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Lewis, G.P. (1970). Kinins in Inflammation and Tissue Injury. In: Erdös, E.G., Wilde, A.F. (eds) Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 25 / 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46222-1_24
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