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Bradykinin and Intracranial Circulation in Man

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Bradykinin, Kallidin and Kallikrein

Abstract

The vessels of the head are sensitive to bradykinin If we inject small doses of this substance intravenously, a transient flush in the face, but not in other parts of the body, is observed. The circulation of the facial skin is more sensitive to bradykinin than other areas of skin are to vasodilating agents. The intracranial extracerebral vasculature also responds quickly to an administration of the polypeptide, but this is demonstrable only with the aid of special techniques. The circulation of the brain seems to be scarcely influenced by polypeptides.

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References

  • Allwood, M. J., Lewis, G. P.: Bradykinin in human blood during vasodilation. J. Physiol. (Lond.) 166, 47P (1963).

    Google Scholar 

  • Allwood, M. J., Lewis, G. P.: Bradykinin and forearm blood flow. J. Physiol. (Lond.) 170, 571 (1964).

    CAS  Google Scholar 

  • Amundsen, E., Rugstad, H. E.: Influence of some pathogenic bacteria on kinin formation and destruction. Brit. J. Pharmacol. 25, 67 (1965).

    PubMed  CAS  Google Scholar 

  • Antony, M., Hinterrerger, H., Lance, J. W.: Plasma serotonin in migraine and stress. Arch. Neurol. (Chic.) 16, 544 (1967).

    Google Scholar 

  • Arcangeli, P., Galletti, R.: La cefalea da istamina. Rass. Neurol. veg. 10, 109 (1953).

    PubMed  CAS  Google Scholar 

  • Armstrong, D., Jepson, J. B., Keele, C. A., Stewart, J. W.: Pain producing substance in human inflammatory exudates and plasma. J. Physiol. (Lond.) 135, 350 (1957).

    CAS  Google Scholar 

  • Armstrong, D., Mills, G. L., Sicuteri, F.: Physiological influence on the liberation of human plasma kinin at low temperature. In: Hypotensive peptides, p. 139, ed. by E. G. Erdös, N. Back and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Astrup, T., Permin, P. M.: Fibrinolysis in the animal organism. Nature (Lond.) 159, 681 (1947).

    CAS  Google Scholar 

  • Atkins, E., Hijn, C., Jr.: Studies on tubercolin fever. III. Mechanism involved in the release of endogenous pyrogen in vitro. J. exp. Med. 122, 207 (1965).

    PubMed  CAS  Google Scholar 

  • Back, N.: In vivo formation of a vasodilator substance by plasmin. Fed. Proc. 19, 55 (1960).

    Google Scholar 

  • Back, N., Wilkens, H., Steger, R.: Fibrinolysis and vasoactive peptides in anaphylaxis In: Hypotensive peptides, p. 485, ed. by E. G. Erdös, N. Back and F. Sicuteri. BerlinHeidelberg-New York: Springer 1966.

    Google Scholar 

  • Bavazzano, A., Del Bene, E., Anselmi, B., Sicuteri, F.: Kinin release by lysosomal labilization in man. Rass. Neurol. Veg. 1, 56 (1968).

    Google Scholar 

  • Bavazzano, A., Fanciullacci, M., Sicuteri, F.: Effetto delle endotossine in dosi subfebbrili su alcuni livelli plasmatici enzimatici (beta-glucuronidasi, fosfatasi) e sulla diuresi nell’uomo. Boll. Soc. ital. Biol. sper. 43, 1403 (1967).

    PubMed  CAS  Google Scholar 

  • Becker, E. L., Kagen, L.: The permeability globulins of human serum and the biochemical mechanism of hereditary angioneurotic edema. Ann. N.Y. Acad. Sci. 116, 866 (1964).

    PubMed  CAS  Google Scholar 

  • Beretta, A. A., Feruglio, F. S., Campus, S., Chiandussi, L., Pandolfo, G., Bert, G.: The effect of eledoisin and bradykinin in the general and visceral circulation. In: Hypotensive peptides, p. 430, ed. by E. G. Erdös, N. Back and F. Sicuteri. Berlin-HeidelbergNew York: Springer 1966.

    Google Scholar 

  • Bertaccini, G., Cei, J. M., Erspamer, V.: The action of physalaemin on the systemic arterial blood pressure of some experimental animals. Brit. J. Pharmacol. 25, 380 (1965).

    PubMed  CAS  Google Scholar 

  • Bertelli, A., Proro, M., Rossano, M. A.: Azione inibente dell’acido epsilon aminocaproico sui fenomeni essudativi ed infiammatori. Atti Accad. med. lombarda 17, 204 (1962).

    CAS  Google Scholar 

  • Bertolini, A., Castelli, M, Mucci, P, Sternieri, E: Relationship between behavioural effect and circulatory changes produced by intra-carotid bradykinin. Proceedings, Internat Symposium on the Pharmacology of Hormonal Polypeptides and Proteins. Milan, Sept. 1968. New York: Plenum Publ. Corpor. 1968.

    Google Scholar 

  • Bertolini, A., Mucci, P., Ferrari, W.: La bradichinina come possibile agente causale dell’ emicrania. III. Effetto dell’iniezione endocisternale di bradichinina nel cane e nel coniglio. Boll. Soc. ital. Biol. sper. 42, 1922 (1966).

    CAS  Google Scholar 

  • Bertolini, A., Sternieri, E.: La bradichinina come possibile agente causale dell’ emicrania. IV. Rapporto tra gli effetti comportamentali e circolatorio della bradichinina, iniettata per via endocarotidea nel coniglio. Boll. Soc. ital. Biol. sper. 43, 794 (1967).

    PubMed  CAS  Google Scholar 

  • Bobbin, R. P., Guth, P. S.: Venoconstrictive action of bradykinin J Pharmacol. exp. Ther. 160, 11 (1967).

    Google Scholar 

  • Bovet, E., Carpi, A., Virno, M.: Pharmacodynamie de la circulation cérébrale. Experientia (Basel) 16, 1 (1960).

    CAS  Google Scholar 

  • Bovet, E., Sicuteri, F.: Vasomotricité cérébrale et allergie. Physiopatologie de la céphalée provoquée par l’histamine. Relazione, 3d Congr. Europeo di Allergologia, vol. II. Rome: Pensiero Scientifico 1956.

    Google Scholar 

  • Braun, C., Guzman, F., Horton, E. W., Lim, E. K. S., Potter, G. D.: Visceral receptors, pain, bradykinin and analgesic agents. J. Physiol. (Lond.) 155, 13 (1961).

    Google Scholar 

  • Breda, G., Concioli, M., Mariani, L.: Shock anafilattico e bradichinina: Confronto tra le modificazioni del circolo corticopiale della cavia. Atti Accad. med. lombarda 17, 335 (1962).

    Google Scholar 

  • Buckley, J. P., Bickerton, R. K., Halliday, R. P., Kato, H.: Central effects of peptides on the cardiovascular system. Ann. N.Y. Acad. Sci. 104, 299 (1963).

    PubMed  CAS  Google Scholar 

  • Capek, R.: Some effects of bradykinin on the central systems. Biochem. Pharmacol. 10, 61 (1961).

    Google Scholar 

  • Cardoso, S. S., Amorin, O. S., Nogueira, A. D., Alencar, J. A., Corrado, A. P., Rego, S. M.: Bradykinin induced leukocytosis in man and in dogs. Proceedings, Internat. Symposium on Vaso-Active Polypeptides, p. 263, ed. by M. Rocha E Silva and H. A. Rothschild. Sao Paulo 1967.

    Google Scholar 

  • Carpi, A., Corrado, A. P.: Cerebral vascular action of bradykinin in the dog. Experientia (Basel) 17, 326 (1961).

    CAS  Google Scholar 

  • Chapman, L. F., Ramos, A. O., Corrado, A. P., Fortes, V.: Release of proteolytic enzymes from cat brain during stimulation. Arch. Neurol. (Chic.) 3, 43 (1960a).

    CAS  Google Scholar 

  • Chapman, L. F., Goodell, H., Silverman, G., Wolff, H. G.: A humoral agent implicated in vascular headache of the migraine type. Arch. Neurol. (Chic.) 3, 223 (1960b).

    CAS  Google Scholar 

  • Chapman, L. F., Wolff, H. G.: Studies of proteolytic enzymes in cerebrospinal fluid. Arch. intern. Med. 103, 86 (1959).

    CAS  Google Scholar 

  • Clarke, J. M.: On recurrent motor paralysis in migraine: With report of a family in which recurrent hemiplegia accompanied the attacks. Brit. med. J. 1910 I, 1534.

    Google Scholar 

  • Cline, M. J., Melmon, K. L.: The effect of cortisol on the plasma kinin system. Proceedings, Internat. Symposium on Vaso-Active Polypeptides, p. 247, ed. by M. Rocha E Silva and H. A. Rothschild. Sao Paulo 1967.

    Google Scholar 

  • Cohx, Z. A., Hirsch, J. G.: The isolation and properties of the specific cytoplasmic granules of rabbit polymorphonuclear leucocytes. J. exp. Med. 112, 983 (1960).

    Google Scholar 

  • Collier, H. O. J., Shorley, P. G.: Analgesic antipyretic drugs as antagonists of bradykinin. Brit. J. Pharmacol. 15, 601 (1960).

    PubMed  CAS  Google Scholar 

  • Concioli, M., Santandrea, E., Villani, R.: Modificazioni del circolo piale sotto l’influsso di particolari stimoli e soprattutto della bradichinina. Rilievi microcinematografici. Atti Accad. med. lombarda 16, 268 (1961).

    CAS  Google Scholar 

  • Cooper, K. E., Cranston, W. I., Honour, M. R. C.: The site of action of leucocyte pyrogen in the rabbit brain. J. Physiol. (Lond.) 18, 1 (1966).

    Google Scholar 

  • Coppen, A. J., Lewis, G. P.: An enzyme forming vasodilator polypeptides in human cerebrospinal fluid. J. Neurochem. 7, 155 (1961).

    PubMed  CAS  Google Scholar 

  • Corrado, A. P.: Recent investigations of the pharmacology of bradykinin and their physiopathological implications. In: Bradykinin and its precursor, ed. by F. Sicuteri. Settim. med. Suppl., 45, 30 (1963).

    Google Scholar 

  • Corrado, A. P., Ramos, A. O., Rocha E Silva, M.: Possiveis acoes centrais da bradicinina. Ciencia e Cultura 11, 165 (1959).

    Google Scholar 

  • Dalessio, D. J., Camp, W. A., Goodell, H., Wolff, H. G.: Studies on headache. The mode of action of UML-491 and its relevance to the nature of vascular headache of the migraine type. Arch. Neurol. (Chic.) 4, 235 (1961).

    CAS  Google Scholar 

  • De Duve, C.: Lysosomes: A new group of cytoplasmic particles. In: Subcellular particles, p. 128, ed. by T. Hayashi. New York: Ronald Press Co. 1959.

    Google Scholar 

  • De Duve, C., Vattiaux, R.: Function of lysosomes. Ann. Rev. Physiol. 28, 435 (1966).

    Google Scholar 

  • Dessy, P., Uslenghi, E., Cagna, C., Accatino, G., Betti, C.: Azione della bradichinina sun’ emodinamica generale e distrettuale. Circolo cerebrale. Minerva med. 57, 3555 (1966).

    PubMed  CAS  Google Scholar 

  • Diniz, C. R., Carvalho, L. F., Dos Reis, M. L., Corrado, A. P.: Bradykininogen in some experimental conditions. Proceedings, Internat. Symposium on Vaso-Active Polypeptides, p. 15, ed. by M. Rocha E Silva and H. A. Rothschild Sao Paulo 1967.

    Google Scholar 

  • Diniz, C. R., Rocha E Silva, M.: A micromethod for the determination of bradykininogen in the blood plasma. Nature (Lond.) 192, 1194 (1961).

    CAS  Google Scholar 

  • Doeifner, W., Cerletti, A.: Comparison of lysergic acid derivates and antihistamines as inhibitor of the edema provoked in the rat’s paw by serotonin. Int. Arch. Allergy 12, 89 (1958).

    Google Scholar 

  • Eisen, V., Keele, C. A.: Possible modes of kinin formation in some pathological states in man. In: Hypotensive peptides, p. 551, ed. by E. G. Erdös, N. Back and F. Sicuterl Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Ekbom, K. A.: Treatment of migraine, Horton’s syndrome and restless legs with Deseril (UML-491). Acta neurol. scand. 38, 313 (1962).

    Google Scholar 

  • Elder, J. M., Wilhelm, D L: Enzyme-like globulins from serum reproducing the vascular phenomena of inflammation. V. Activable permeability factor in human serum. Brit. J. exp. Path. 39, 23 (1958).

    Google Scholar 

  • Erdös, E. G.: Hypotensive peptides. Bradykinin, kallidin and eledoisin. Advanc. Pharmacol. 4, 1 (1966).

    Google Scholar 

  • Erdös, E. G., Sloane, E. M.: An enzyme in human blood plasma that inactivates bradykinin and kallidin. Biochem. Pharmacol. 11, 585 (1962).

    PubMed  Google Scholar 

  • Erdös, E. G., Wohler, J. R.: Inhibitors of the in vivo effects of bradykinin and kallidin. Life Sci. 2, 270 (1963).

    Google Scholar 

  • Erdös, E. G., Levine, M. I.: Blocking of the in vivo effects of bradykinin with carboxypeptidase B. J. Pharmacol. exp. Ther. 142, 327 (1963).

    Google Scholar 

  • Erspamer, V.: Pharmacologically active substances of mammalian origin. Ann. Rev. Pharmacol. 1, 175 (1961).

    CAS  Google Scholar 

  • Erspamer, V., Anastasi, A.: Structure and pharmacological actions of eledoisin, the active endecapeptide of the posterior glands of eledone. Experientia (Basel) 18, 58 (1962).

    CAS  Google Scholar 

  • Erspamer, V., Bertaccini, G., Cei, J. M.: Structure and pharmacological actions of physalaemin, the main active polypeptides of the skin of Physalaemus fuscumaculatus. Experientia (Basel) 20, 489 (1964).

    CAS  Google Scholar 

  • Erspamer, V., Glasser, A.: The action of eledoisin on the systemic arterial blood pressure of some experimental animals. Brit. J. Pharmacol. 20, 516 (1963).

    PubMed  CAS  Google Scholar 

  • Fishman, W. H., Springer, B., Brunetti, R.: Application of an improved glucuronidase assay method to the study of human blood beta-glucuronidase. J. biol. Chem. 173, 449 (1948).

    PubMed  CAS  Google Scholar 

  • Friedmann, A. P., Elkind, A.: Appraisal of methysergide in treatment of vascular headache of migraine type. J. Amer. med. Ass. 184, 125 (1961).

    Google Scholar 

  • Gelfand, M. D., West, G. B.: Experimental studies with the butanolamide and propanol-amide of 1-methyl-lysergic acid. Int. Arch. Allergy 18, 288 (1961).

    Google Scholar 

  • Gilfoil, T. M., Klavins, I.: 5-Hydroxytryptamine, bradykinin and histamine as mediators of inflammatory hyperesthesia. Amer. J. Physiol. 208, 867 (1965).

    PubMed  CAS  Google Scholar 

  • Goodwin, L. G., Boreham, P. F. L.: Pharmacologically active peptides in trypanosome infections. In: Hypotensive peptides, p. 545, ed. by E. G. Erdös, N. Back and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Graeff, F. G., Corrado, A. P., Pela, J. P., Capek, R.: Actions of bradykinin upon the central nervous system. Proceedings, Internat. Symposium on Vaso-Active Polypeptides, p. 97, ed. by M. Rocha E Silva and H. A. Rothschild Sao Paulo 1967.

    Google Scholar 

  • Graeff, F. G., Ferreira, S. H., Corrado, A. P., Rocha E Silva, M.: Potentiation of the cerebral vascular action of bradykinin by the bradykinin potentiating factor (BPF) in the dog. Experientia (Basel) 21, 607 (1965).

    CAS  Google Scholar 

  • Greenbaum, L. M., Kim, K. S.: The kinin-forming and kininase activities of rabbit polymorphonuclear leucocytes. Brit. J. Pharmacol. 29, 372 (1967).

    Google Scholar 

  • Greenbaum, L. M., Yamafuji, K., Kim, K. S.: Studies on the kinin-forming and inactivating enzymes in tissue and leucocytes. Proceedings, Internat. Symposium on Vaso-Active Polypeptides, p. 21, ed. by M. Rocha E Silva and H. A. Rothschild Sao Paulo 1967.

    Google Scholar 

  • Greppi, E., Martinetti, R.: Le cefalee. Proceedings, 49th Congr. Ital. Soc. of Internal Medicine. Rome: Pozzi 1948.

    Google Scholar 

  • Greppi, E., Sicuteri, F.: L’Emicrania-motivi di fisiopatogenesi e di terapia. Proceedings, 65th Congr. Ital. Soc. of Internal Medicine. Rome: Pozzi 1964.

    Google Scholar 

  • Haefely, W., Hurlimann, A., Thoenen, H.: The effects of bradykinin and angiotensin on ganglionic transmission. In: Hypotensive peptides, p. 314, ed. by E. G. Erdös, N. Back and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Hilton, S. M., Schain, R. J.: A search for pharmacologically active substances in fluid from the cerebral ventricles. J. Physiol. (Lond.) 157, 46P (1961).

    Google Scholar 

  • Horton, E. W.: An increase in butanol-extractable 5-hydroxytryptamine in venous blood during reactive hyperemia. J. Physiol. (Lond.) 170, 101 (1964).

    CAS  Google Scholar 

  • Janoff, A., Schaeffer, S.: Mediators of acute inflammation in leucocyte lysosomes. Nature (Lond.) 214, 144 (1967).

    Google Scholar 

  • Jelliffe, S. E.: Aphasia, hemiparesis and hemianaesthesia in migraine. N.Y. St. Med. J. 83, 33 (1906).

    Google Scholar 

  • Kappas, A., Hellman, L., Fukushima, D. K., Gallagher, T. F.: The pyrogenic effect of ethiocolanone (3-d-hydroxyetiocholane-17-one). J. clin. Endocr. 16, 948 (1956).

    Google Scholar 

  • Keele, C. A., Armstrong, D.: Mediators of pain. In: Pharmacology of pain, vol. 9, p. 3, ed. by Lue, Armstrong and Prado. Oxford: Pergamon Press 1968.

    Google Scholar 

  • Kety, S. S., Schmidt, C. F.: Nitrous oxide method for the quantitative determination of cerebral blood flow in man: Theory, procedure and normal values. J. clin. Invest. 27, 476 (1948).

    Google Scholar 

  • Krivoy, W. A., Lane, M., Kroeger, D. C.: The actions of certain polypeptides on synaptic transmission. Ann. N.Y. Acad. Sci. 104, 312 (1963).

    PubMed  CAS  Google Scholar 

  • Kwaan, H. C., Mcfadzean, A. J. C.: On plasma fibrinolytic activity induced by ischemia. Clin. Sci. 16, 245 (1956).

    Google Scholar 

  • Lance, J. W., Anthony, M., Hinterberger, H.: The control of cranial arteries by humoral mechanisms and its relation to the migraine syndrome. Headache 7, 93 (1967).

    PubMed  CAS  Google Scholar 

  • Landerman, N. S., Webster, M. E., Becker, E. L., Ratcliffe, H. E.: Hereditary angioneurotic edema. II. Deficiency of inhibitor for serum globulin permeability factor and/or plasma kallikrein. J. Allergy 33, 330 (1960).

    Google Scholar 

  • Lewis, G.: In: Proceedings, First Internat. Pharmacol. Meeting, vol. 9, p. 65, ed. by M. Rocha E Silva and U. S. Von Euler. Oxford: Pergamon Press 1963.

    Google Scholar 

  • Lim, R. K. S., Miller, D. G., Gurman, F., Rodgers, D. W., Rodgers, R. W., Wang, S. K., Chao, P. Y., Shin, T. Y.: Pain and analgesia evaluated by the intraperitoneal bradykinin evoked pain method in man. Clin. Pharmacol. Ther. 8, 521 (1967).

    PubMed  CAS  Google Scholar 

  • Lunedei, A.: Sulle flogosi fronto-basilari iperergiche. Rev. clin. Med. 48, 81 (1948).

    Google Scholar 

  • Lunedei, A., Serafini, V., Arcangeli, P., Noferi, G., Pratesi, F., Doni, A., Milano, M.: Apoplessia cerebrale. Il problema etiopatogenetico. Proceedings, 58th Congr. Ital. Med. Soc. Rome: Pozzi 1957.

    Google Scholar 

  • Mackay, M. E., Miles, A. A., Schachter, C. B. E., Wilhelm, D L: Susceptibility of the guinea pig to pharmacological factors from its own serum. Nature (Lond.) 172, 714 (1953).

    CAS  Google Scholar 

  • Mashford, M. L., Zacest, R.: Effect of adrenaline on blood kininase activity in man. Suppl. III, Circulat. Res. 20 /21, 183 (1967).

    Google Scholar 

  • Melmon, K. L., Cline, M J: Kinins and granulocytes: Model of inflammation. Proceedings, Internat. Symposium on Vaso-Active Polypeptides, p. 223, ed. by M. Rocha E Silva and H. A. Rothschild. Sao Paulo 1967.

    Google Scholar 

  • Miles, A. A.: Local and systemic factors in shock. Fed. Proc. 20, 1941 (1961).

    Google Scholar 

  • Miles, A. A., Wilhelm, D L: Enzyme-like globulins from serum reproducing the vascular phenomena of inflammation. An activable permeability factor and its inhibitor in guinea-pig serum. Brit. J. exp. Path. 36, 71 (1955).

    PubMed  CAS  Google Scholar 

  • Oates, J. A., Melmon, K. L.: Biochemical and physiological studies of kinins in carcinoid syndrome. In: Hypotensive peptides, p. 565, ed. by E. G. Erdös, N. Back and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Palmer, R. H., Ratkovits, B., Kappas, A.: Steroid pyrogen studies in laboratory domestic animals. J. appl. Physiol. 16, 345 (1961).

    PubMed  CAS  Google Scholar 

  • Pekkarinen, A., Castren, O., Iisalo, E., Koivusalo, M., Laihinena, Simola, P. E., Thomasson, B.: The emotional effect of matriculation examinations on the excretion of adrenaline, noradrenaline, 17-hydroxycorticosteroids into the urine and the content of 17-hydroxycorticosteroids in the plasma. Biochemistry, pharmacology and physiology, p. 117. Oxford: Pergamon Press 1961.

    Google Scholar 

  • Periti, P., Comparini, A., Sicuteri, F.: Bradichinogeno in corso di malattie infettive acute. Boll. Soc. ital. Biol. sper. 39, 327 (1963a).

    PubMed  CAS  Google Scholar 

  • Periti, P., Michelacci, S., Santini, D.: Plasmachinine libere nel sangue umano. Boll. Soc. ital. Biol. sper. 39, 307 (1963b).

    PubMed  CAS  Google Scholar 

  • Periti, P., Sicuteri, F., Franchi, G., Michelacci, S.: Azione dell’istamino-liberatore 48/80 sul bradichinogeno e plasmachinine del sangue venoso dopo somministrazione endovenosa ed endoarteriosa. Boll. Soc. ital. Biol. sper. 40, 951 (1964).

    Google Scholar 

  • Pickering, G. W.: Experimental observations on headache. Brit. med. J. 1939 I, 4087.

    Google Scholar 

  • Pickering, G. W., Hess, W.: Observations on the mechanism of headache produced by histamine. Clin. Sci. 1, 77 (1933).

    CAS  Google Scholar 

  • Rafter, G. W., Collins, R. D., Wood, W. B.: Studies on the pathogenesis of fever. Preliminary chemical characterization of leucocytic pyrogen. J. exp. Med. 111, 831 (1960).

    PubMed  CAS  Google Scholar 

  • Rocha E., Silva, M.: Autofarmacologia e venenos animais. Ciencia e Cultura 2, 44 (19501.

    Google Scholar 

  • Rocha E., Silva, M.: Physiological significance of bradykinin. Ann. N.Y. Acad. Sci. 104, 190 (1963).

    Google Scholar 

  • Rocha E., Reis, M. L., Ferreira, S. H.: Release of kinins from fresh plasma under varying experimental conditions. Biochem. Pharmacol. 16, 1665 (1967).

    Google Scholar 

  • Schachter, M.: A delayed slow contracting effect of serum and plasma due to the formation of a substance resembling bradykinin and kallidin. Brit. J. Pharmacol. 11, 111 (1956).

    PubMed  CAS  Google Scholar 

  • Shimamoto, T., Nimano, F., Ftjita, T., Jshiota, T., Atsumi, T.: Treatment of experimental and human atherosclerosis with bradykinin antagonist, pyridinolcarbamate: A preliminary report. In: Hypotensive peptides, p. 506, ed. by E. G. Erdös, N. Back and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Sicuteri, F.: Il test liquorale per lo studio della vasomotilita intracranica. Triangle 4, 149 (1959a).

    Google Scholar 

  • Sicuteri, F.: Prophylactic and therapeutic properties of 1-methyl-lysergic acid butanolamide in migraine. Int. Arch. Allergy 15, 300 (1959b).

    PubMed  CAS  Google Scholar 

  • Sicuteri, F.: Mast cells and their active substances: Their role in the pathogenesis of migraine. Headache 3, 86 (1963).

    PubMed  CAS  Google Scholar 

  • Sicuteri, F.: Headache and meningismus evoked by lumbar and subarachnoid hemorrhage. A biochemical interpretation. Headache 5, 108 (1966).

    PubMed  CAS  Google Scholar 

  • Sicuteri, F.: Vasoneuroactive substances and their implication in vascular pain. In: Research and clinical studies in headache, p. 6, ed. by Friedman. Basel 1967 a.

    Google Scholar 

  • Sicuteri, F.: Sensitization of nociceptors by 5-hydroxytryptamine in man. In: Proceedings, 3rd Internat. Pharmacol. Congr., p. 57. Oxford 1967 b.

    Google Scholar 

  • Sicuteri, F.: Treatment of subarachnoid and other intracranial hemorrhages with proteinase inhibitors. In: Chemistry, pharmacology and clinical applications of proteinase inhibitors. Ann. N.Y. Acad. Sci. 146, 682 (1968).

    Google Scholar 

  • Sicuteri, F., Anselmi, B., Del Bene, E.: Il pirogeno in dosi non febbrigene come test rivelatore di flogosi croniche intracraniche. Rif. med. 44, 1 (1966a).

    Google Scholar 

  • Sicuteri, F., Del Bianco, P. L., Fanciullacci, M., Franchi, G.: Il test della venocostrizione per la misura della sensibilita alla 5-idrossitriptamina e alle catecolamine nell’uomo. Boll. Soc. ital. Biol. sper. 40, 1148 (1964a).

    PubMed  CAS  Google Scholar 

  • Sicuteri, F., Fanciullacci, M., Bavazzano, A., Franchi, G.: Influenza di un inibitore della callicreina sulla fenomenologia da emorragia intracranica sperimentale. Boll. Soc. ital. Biol. sper. 43, 1061 (1967a).

    Google Scholar 

  • Sicuteri, F., Del Bianco, P. L.: Vasoattivitâ dell’endecapeptide fisalemina nell’uomo. Settim. med. 52, 1221 (1964b).

    Google Scholar 

  • Sicuteri, F., Franchi, G., Del Bianco, P. L.: Serotonin-bradykinin potentiation on the pain receptors in man. Life Sci. 4, 309 (1965a).

    PubMed  CAS  Google Scholar 

  • Sicuteri, F., Franchi, G., Del Bianco, P. L., Michelacci, S.: The endecapeptide eledoisin as powerful vasodilating and hypotensive agent in man. Experientia (Basel) 19, 44 (1963d).

    CAS  Google Scholar 

  • Sicuteri, F., Franchi, G., Del Bianco, P. L.: Un test per lo studio dell’azione dolorifica della bradi-chinina nell’animale: Il fenomeno grido-fuga del coniglio. Boll. Soc. ital. Biol. sper. 42, 845 (1966b).

    PubMed  CAS  Google Scholar 

  • Sicuteri, F., Franchi, G., Del Bianco, P. L.: An antiaminic drug, BC-105, in the prophylaxis of migraine. Int. Arch. Allergy 31, 78 (1967c).

    PubMed  CAS  Google Scholar 

  • Sicuteri, F., Fanciullacci, M.: Peptides and pain. Proceedings, Internat. Symposium on Vaso-Active Polypeptides, p. 251, ed. by M. Rocha E Silva and H. A. Rothschild Sao Paulo 1967 b.

    Google Scholar 

  • Sicuteri, F., Fanciullacci, M., Del Bianco, P. L., Siddel, N.: Adrenergic receptors and kinins. In: Pharmacology of hormonal polypeptides and proteins, p. 601. Ed. by N. Back, L. Martini and R. Paoletti. New York: Plenum Press 1968.

    Google Scholar 

  • Sicuteri, F., Michelacci, S.: Prime osservazioni sull’effetto della bradichinina sul circolo cerebrale nell’uomo. Settim. med. 49, 7 (1961b).

    Google Scholar 

  • Sicuteri, F., Periti, P.: Physiopathological aspects of bradykinin and its precursor in man. In: Bradykinin and its precursor, p. 53, ed. by F. Sicuteri. Rome: Publ. C.E.P.I. 1963 a.

    Google Scholar 

  • Sicuteri, F., Michelacci, S., Anselmi, B.: Termination of migraine headache by a new anti-inflammatory vasoconstrictor agent. Clin. Pharmacol. Ther. 6, 336 (1965b).

    PubMed  CAS  Google Scholar 

  • Sicuteri, F., Periti, P., Anselmi, B., Fanciullacci, M.: Livelli plasmachininici nell’uomo dopo somministrazione venosa ed endoarteriosa di bradichinina sintetica e naturale. Boll. Soc. ital. Biol. sper. 39, 314 (1963c).

    PubMed  CAS  Google Scholar 

  • Sicuteri, F., Franchi, G.: Bradichininogeno e chinine libere nel liquido cefalorachidiano dell’uomo. Boll. Soc. ital. Biol. sper. 40, 67 (1963b).

    Google Scholar 

  • Sicuteri, F., Periti, P., Gasparri, F., Franchi, G., Fanciullacci, M.: Diminuzione del tasso ematico di bradichininogeno nell’uomo dopo somministrazione di adrenalina e callicreina. Boll. Soc. ital. Biol. sper. 38, 1033 (1962).

    CAS  Google Scholar 

  • Sicuteri, F., Ricci, M., Monfariini, R., Ficini, M.: Cefalea sperimentale da istamina endogena. Settim. med. 44, 583 (1956).

    Google Scholar 

  • Sicuteri, F., Testi, A., Anselmi, B.: Biochemical investigations in headache: Increase in the hydroxyindoleacetic acid during migraine attacks. Int. Arch. Allergy 19, 55 (1961a).

    CAS  Google Scholar 

  • Sternieri, E., Mucci, P., Bertolini, A.: Modificazioni indotte farmacologicamente dalla risposta del circolo cerebrale alla bradichinina. 1. Rapporto tra vocalizzazione ed aumento del sangue nel territorio cerebrale. Boll. Soc. ital. Biol. sper. 43, 1196 (1967).

    PubMed  CAS  Google Scholar 

  • Sutherland, A. M., Wolff, H. G.: Experimental studies on headache: Further analysis of the mechanism of headache in migraine, hypertension and fever. Arch. Neurol. Psychiat. (Chic.) 44, 929 (1940).

    Google Scholar 

  • Trautschold, I., Fritz, H., Werle, E.: Kininogenases, kininases and their inhibitors. In: Hypotensive peptides, p. 221, ed. by E. G. Erdös, N. Back and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

  • Tunis, M. M., Goodell, H., Wolff, H. G.: Studies on headache: Evidence of tissue damage and changes in pain sensitivity in subjects with vascular headache of the migraine type. Trans. Ass. Amer. Phycns 66, 332 (1953).

    Google Scholar 

  • Virno, M., Gertner, S. B., Bovet, D.: Action of histamine on the jugular venous pressure and cerebral circulation of the dog. Effects of antihistaminic drugs (pyrilamine and chlorpheniramine) and histamine liberating agent (48/80 B.W.). J. Pharmacol. exp. Ther. 118, 63 (1956).

    PubMed  CAS  Google Scholar 

  • Vogt, W.: Kinin formation by plasmin, an indirect process mediated by activation of kallikrein J. Physiol. (Lond.) 170, 153 (1964).

    CAS  Google Scholar 

  • Webster, M. E., Innerfield, I.: Interrelationship of human plasma kallikrein and plasmin in inflammation. Enzymol. biol. clin. 5, 129 (1965).

    CAS  Google Scholar 

  • Weissmann, G.: Labilization and stabilization of lysosomes. Fed. Proc. 23, 1038 (1964).

    PubMed  CAS  Google Scholar 

  • Weissmann, G.: Lysosomes. New Engl. J. Med. 11, 1084 (1965).

    Google Scholar 

  • Weissmann, G., Lewis, G. P.: Studies on lysosomes. The effect of endotoxin tolerance and cortisone on the release of hydrolases from a granular fraction of rabbit liver. J. exp. Med. 116, 433 (1962).

    PubMed  CAS  Google Scholar 

  • Weissmann, G., Thomas, L.: On a mechanism of tissue damage by bacterial endotoxin. In: Bacterial endotoxins, ed. by M. Landy and W. Braun. New Brunswick: Rutgers University Press 1964.

    Google Scholar 

  • Werle, E., Trautschold, I.: Kallikrein, kallidin, kallikrein inhibitors. Ann. N.Y. Acad. Sci. 104, 117 (1963).

    PubMed  CAS  Google Scholar 

  • Whitty, C. W. H.: Familial hemiplegic migraine. J. Neurol. Neurosurg. Psychiat. 16, 172 (1953).

    PubMed  CAS  Google Scholar 

  • Wolff, H. G.: Headache and cranial arteries. Trans. Ass. Amer. Phycns 58, 193 (1938).

    Google Scholar 

  • Wolff, H. G.: Headache and other head pain. Oxford: Univ. Press 1963.

    Google Scholar 

  • Wolff, H. G., Tuxes, M. M.: Analysis of cranial artery pressure pulse waves in patients with vascular headache of the migraine type. Trans. Ass. Amer. Phycns 65, 240 (1952).

    CAS  Google Scholar 

  • Wood, W. B., Jr.: The role of endogenous pyrogen in the genesis of fever. Lancet 1958 II, 53.

    Google Scholar 

  • Zetler, G., Lembeck, F.: Substance P, a polypeptide of possible physiological importance, especially for the Central nervous system. Int. Rev. Neurobiol. 4, 159 (1962).

    Google Scholar 

  • Zweifach, B. W.: Microcirculatory effects of polypeptides. In: Hypotensive peptides, p. 451, ed. by E. G. Erdös, N. Back and F. Sicuteri. Berlin-Heidelberg-New York: Springer 1966.

    Google Scholar 

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Authors
  1. Federigo Sicuteri
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Editors and Affiliations

  1. Department of Pharmacology, University of Oklahoma Medical Center, Oklahoma City, Oklahoma, USA

    Ervin G. Erdös

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Sicuteri, F. (1970). Bradykinin and Intracranial Circulation in Man. In: Erdös, E.G., Wilde, A.F. (eds) Bradykinin, Kallidin and Kallikrein. Handbook of Experimental Pharmacology / Handbuch der experimentellen Pharmakologie, vol 25 / 25. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-46222-1_23

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  • DOI: https://doi.org/10.1007/978-3-642-46222-1_23

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