Abstract
A conclusive mapping of myeloarchitecture (myelin patterns) onto the cortical sheet and, thus, a corresponding mapping to cytoarchitecture (cell configuration) does not exist today. In this paper we present a generative model which can predict, on the basis of known cytoarchitecture, myeloarchitecture in different primary and non-primary cortical areas, resulting in simulated in-vivo quantitative T1 maps. The predicted patterns can be used in brain parcellation. Our model is validated using a similarity distance metric which enables quantitative comparison of the results with empirical data measured using MRI. The work presented may provide new perspectives for this line of research, both in imaging and in modelling the relationship with myelo- and cytoarchitecture, thus leading the way towards in-vivo histology using MRI.
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Brodmann, K.: Vergleichende Lokalisationslehre der Großhirnrinde in ihren Prinzipien dargestellt auf Grund des Zellenbaues. JA Barth, Leipzig (1909)
Economo, C., Koskinas, G.N.: Die Cytoarchitektonik der Hirnrinde des Erwachsenen Menschen. Wien und Berlin (1925)
Vogt, C., Vogt, O.: Allgemeinere Ergebnisse unserer Hirnforschung. Erste Mitteilung. Ziele und Wege unserer Hirnforschung. J. Psychol. Neurol. 25 (1919)
Nieuwenhuys, R.: The myeloarchitectonic studies on the human cerebral cortex of the Vogt–Vogt school, and their significance for the interpretation of functional neuroimaging data. Brain. Struct. Funct. 218, 303–352 (2013)
Hellwig, B.: How the myelin picture of the human cerebral cortex can be computed from cytoarchitectural data. A bridge between von Economo and Vogt. J. Hirnforsch. 34, 387–402 (1993)
Wald, L., Fischl, B., Rosen, B.: High-Resolution and Microscopic Imaging at High Field. In: Ultra High Field Magnetic Resonance Imaging, pp. 343–371. Springer, New York (2006)
Geyer, S., Weiss, M., Reimann, K., Lohmann, G., Turner, R.: Microstructural Parcellation of the Human Cerebral Cortex–From Brodmann’s Post-Mortem Map to in vivo Mapping with High-Field Magnetic Resonance Imaging. Front. Hum. Neurosci. 5 (2011)
Glasser, M.F., Van Essen, D.C.: Mapping Human Cortical Areas In Vivo Based on Myelin Content as Revealed by T1-and T2-Weighted MRI. J. Neurosci. 31, 11597 (2011)
Fischl, B., Rajendran, N., Busa, E., Augustinack, J., Hinds, O., Yeo, B.T., Mohlberg, H., Amunts, K., Zilles, K.: Cortical Folding Patterns and Predicting Cytoarchitecture. Cereb. Cortex. 18, 1973–1980 (2008)
Paldino, A.M.: A computerized study of axonal structure in the visual cortex. Syracuse University (1975)
Rooney, W.D., Johnson, G., Li, X., Cohen, E.R., Kim, S.G., Ugurbil, K., Springer, C.S.: Magnetic field and tissue dependencies of human brain longitudinal 1H2O relaxation in vivo. Magn. Reson. Med. 57, 308–318 (2007)
Marques, J.P., Kober, T., Krueger, G., van der Zwaag, W., Van de Moortele, P.F., Gruetter, R.: MP2RAGE, a self bias-field corrected sequence for improved segmentation and T1-mapping at high field. NeuroImage 49, 1271–1281 (2010)
Hurley, A.C., Al-Radaideh, A., Bai, L., Aickelin, U., Coxon, R., Glover, P., Gowland, P.A.: Tailored RF pulse for magnetization inversion at ultra-high field. Magn. Reson. Med. 63, 51–58 (2010)
Han, X., Pham, D.L., Tosun, D., Rettmann, M.E., Xu, C., Prince, J.L.: CRUISE: Cortical reconstruction using implicit surface evolution. NeuroImage 23, 997–1012 (2004)
Bok, S.T.: Der Einfluß der in den Furchen und Windungen auftretenden Krümmungen der Großhirnrinde auf die Rindenarchitektur. Arch. Neurol. Psychiatr. 121, 682–750 (1929)
Geyer, S., Schleicher, A., Zilles, K.: Areas 3a, 3b, and 1 of human primary somatosensory cortex: 1. Microstructural Organization and Interindividual Variability. NeuroImage 10, 63–83 (1999)
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Dinse, J. et al. (2013). A Histology-Based Model of Quantitative T1 Contrast for In-vivo Cortical Parcellation of High-Resolution 7 Tesla Brain MR Images. In: Mori, K., Sakuma, I., Sato, Y., Barillot, C., Navab, N. (eds) Medical Image Computing and Computer-Assisted Intervention – MICCAI 2013. MICCAI 2013. Lecture Notes in Computer Science, vol 8150. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-40763-5_7
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DOI: https://doi.org/10.1007/978-3-642-40763-5_7
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