Abstract
Patch clamping was first introduced into biophysical studies by Neher and Sakmann [1] in 1976 and was soon expanded to many other fields such as biology and medicine. The technique not only allowed the detection of single-channel currents in biological membranes for the first time but also enabled higher current resolution, direct membrane patch potential control, and physical isolation of membrane patches [2]. The development of the patch clamp method was honoured with a Nobel Prize in 1991.
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Malboubi, M., Jiang, K. (2014). Development of Patch Clamping. In: Gigaseal Formation in Patch Clamping. SpringerBriefs in Applied Sciences and Technology. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-39128-6_2
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DOI: https://doi.org/10.1007/978-3-642-39128-6_2
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