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RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates

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Intrinsic Immunity

Part of the book series: Current Topics in Microbiology and Immunology ((CT MICROBIOLOGY,volume 371))

Abstract

In invertebrates such as insects and nematodes, RNA interference (RNAi) provides RNA-based protection against viruses. This form of immunity restricts viral replication and dissemination from infected cells and viruses, in turn, have evolved evasion mechanisms or RNAi suppressors to counteract host defenses. Recent advances indicate that, in addition to RNAi, other related small RNA pathways contribute to antiviral functions in invertebrates. This has led to a deeper understanding of fundamental aspects of small RNA-based antiviral immunity in invertebrates and its contribution to viral spread and pathogenesis.

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Acknowledgments

We apologize to colleagues whose relevant publications were not cited because of space constraints. We thank Cecily Burrill, member of the RA laboratory for critical reading of the manuscript. We thank Kirk Ehmsen and Ashesh Saraiya for their helpful comments and discussion. Research in RA laboratory is financially supported by National Institute Health grants R01 AI40085 and AI064738.

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Authors and Affiliations

  1. Department of Microbiology and Immunology, University of California, San Francisco, 94122-2280, USA

    Arabinda Nayak, Michel Tassetto, Mark Kunitomi & Raul Andino

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  1. Arabinda Nayak
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  2. Michel Tassetto
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  3. Mark Kunitomi
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  4. Raul Andino
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Correspondence to Raul Andino .

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  1. Center for Virology, Department of Molecular Genetics and Mic, Duke University Medical Center, Research Drive 213, Durham, 27710, North Carolina, USA

    Bryan R. Cullen

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Nayak, A., Tassetto, M., Kunitomi, M., Andino, R. (2013). RNA Interference-Mediated Intrinsic Antiviral Immunity in Invertebrates. In: Cullen, B. (eds) Intrinsic Immunity. Current Topics in Microbiology and Immunology, vol 371. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37765-5_7

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