Editors:
- Written by leading experts in the field
- Provides a better understanding of the co-evolution of viral pathogens and their hosts
- Offers perspectives for the design of antiviral drugs
- Includes supplementary material: sn.pub/extras
Part of the book series: Current Topics in Microbiology and Immunology (CT MICROBIOLOGY, volume 371)
Buy it now
Buying options
Tax calculation will be finalised at checkout
Other ways to access
This is a preview of subscription content, log in via an institution to check for access.
Table of contents (9 chapters)
-
Front Matter
-
Back Matter
About this book
Recent research has focused attention on the importance of intrinsic antiviral immunity, i.e. immunity mediated by factors that are constitutively expressed in many cells. In this volume, leading experts provide a comprehensive overview of this relatively new and rapidly evolving field. They cover intrinsic proteinaceous antiviral immune effectors, such as the APOBEC3 and TRIM protein families as well as Tetherin and SAMHD1, which were initially discovered by researchers studying HIV-1. Furthermore, the role of RNA interference in antiviral defense in plants and invertebrates, as well as the interplay between microRNAs and viruses in mammalian cells, are analysed. One chapter discusses how intrinsic immunity and viral countermeasures to intrinsic immune effectors drive both pathogen and host evolution, and finally the emerging evidence that DNA damage response proteins restrict infection by DNA viruses is highlighted.
Â
Editors and Affiliations
-
Center for Virology, Department of Molecular Genetics and Mic, Duke University Medical Center, Durham, USA
Bryan R. Cullen
Bibliographic Information
Book Title: Intrinsic Immunity
Editors: Bryan R. Cullen
Series Title: Current Topics in Microbiology and Immunology
DOI: https://doi.org/10.1007/978-3-642-37765-5
Publisher: Springer Berlin, Heidelberg
eBook Packages: Biomedical and Life Sciences, Biomedical and Life Sciences (R0)
Copyright Information: The Editor(s) (if applicable) and The Author(s), under exclusive license to Springer-Verlag GmbH, DE, part of Springer Nature 2013
Hardcover ISBN: 978-3-642-37764-8Published: 03 June 2013
Softcover ISBN: 978-3-642-42763-3Published: 16 June 2015
eBook ISBN: 978-3-642-37765-5Published: 17 May 2013
Series ISSN: 0070-217X
Series E-ISSN: 2196-9965
Edition Number: 1
Number of Pages: VII, 262
Topics: Immunology, Virology, Microbial Genetics and Genomics, Molecular Medicine, Plant Pathology, Invertebrates
Industry Sectors: Biotechnology, Consumer Packaged Goods, Health & Hospitals, Pharma