Zusammenfassung
Die 2008 eingeführte Einteilung in „Herztherapeutika“ umfasst die früheren Gruppen Antiarrhythmika, Kardiaka und Koronarmittel. Die Klassifikation orientiert sich primär an therapeutischen Kriterien und weniger an pharmakologischen Wirkungen, weil Nitrate und Molsidomin ihren Hauptangriffspunkt nicht am Herzmuskel oder den Koronarien, sondern an peripheren Gefäßen haben. Die Zusammenfassung folgt dem ATC-System der WHO und erscheint wegen des kontinuierlichen Rückgangs der Verordnungen in den drei Bereichen angemessen.
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Literatur
Aarnoudse AL, Dieleman JP, Stricker BH (2007): Age- and gender-specific incidence of hospitalisation for digoxin intoxication. Drug Saf 30: 431–436.
Ahmed A, Waagstein F, Pitt B, White M, Zannad F, Young JB, Rahimtoola S (2009): Effectiveness of Digoxin in Reducing One-Year Mortality in Chronic Heart Failure in the Digitalis Investigation Group Trial. Am J Cardiol 103: 82–87.
Bardy GH, Lee KL, Mark DB, Poole JE, Packer DL, Boineau R et al. (2005): Amiodaron or an implantable cardioverter-defibrillator for congestive heart failure. N Engl J Med 352: 225–237.
Castagno D , Petrie MC, Claggett B, McMurray J (2012): Should we SHIFT our thinking about digoxin? Observations on ivabradine and heart rate reduction in heart failure. Eur Heart J 33: 1137–41.
Connolly SJ, Camm AJ, Halperin JL, Joyner C, Alings M et al. PALLAS Investigators (2011): Dronedarone in high-risk permanent atrial fibrillation. N Engl J Med 365: 2268–76.
Echt DS, Liebson PR, Mitchell LB, Peters RW, Obias-Manno D, Barker AH et al. (1991): Mortality and morbidity in patients receiving encainide, flecainide, or placebo. N Engl J Med 324: 781–788.
Fetsch T, Bauer P, Engberding R, Koch HP, Lukl J, Meinertz T, Oeff M, Seipel L, Trappe HJ, Treese N, Breithardt G (2004): Prevention of atrial fibrillation after cardioversion: results of the PAFAC trial. Eur Heart J. 25: 1385–94.
Fox K, Ford I, Steg PG, Tendera M, Ferrari R (2008) Ivabradine for patients with stable coronary artery disease and left-ventricular dysfunction (BEAUTIFUL): a randomised, double-blind, placebo-controlled trial. Lancet 372: 807–816.
Gori T, Al-Hesayen A, Jolliffe C, Parker JD (2003): Comparison of the effects of pentaerythritol tetranitrate and nitroglycerin on endothelium-dependent vasorelaxation in male volunteers.Am J Cardiol 91: 1392–1394.
Hirayama A, Kodama K, Yui Y, Nonogi H, Sumiyoshi T, Origasa H, Hosoda S, Kawai C, Japan Multicenter Investigation for Cardiovascular Diseases-Mochida Investigators (2003): Effect of trapidil on cardiovascular events in patients with coronary artery disease (results from the Japan Multicenter Investigation for Cardiovascular Diseases- Mochida [JMIC-M]). Am J Cardiol 92: 789–793.
Hocini M, Jais P, Sanders P, Takahashi Y, Rotter M, Rostock T, Hsu LF, Sacher F, Reuter S, Clementy J, Haissaguerre M (2005): Techniques, evaluation, and consequences of linear block at the left atrial roof in paroxysmal atrial fibrillation: a prospective randomized study. Circulation 112: 3688–3696.
Hohnloser SH, Crijns HJ, van Eickels M, Gaudin C, Page RL, Torp-Pedersen C, Connolly SJ; ATHENA Investigators (2009): Effect of dronedarone on cardiovascular events in atrial fibrillation. N Engl J Med 360: 668–678.
Jurt U, Gori T, Ravandi A, Babaei S, Zeman P, Parker JD (2001): Differential effects of pentaerythritol tetranitrate and nitroglycerin on the development of tolerance and evidence of lipid peroxidation: a human in vivo study. J Am Coll Cardiol 38: 854–859.
Kassenärztliche Bundesvereinigung (2012): Verordnungssteuerung. Pentalong® ist nicht verordnungsfähig. Internet: www.kbv.de/40842.html
Køber L, Torp-Pedersen C, McMurray JJ, Gøtzsche O, Lévy S, Crijns H, Amlie J, Carlsen J; Dronedarone Study Group (2008): Increased mortality after dronedarone therapy for severe heart failure. N Engl J Med 358: 2678–2687.
Lehmann G, Reiniger G, Beyerle A, Schomig A (1998): Clinical comparison of antiischemic efficacy of isosorbide dinitrate and molsidomine. J Cardiovasc Pharmacol 31: 25–30.
Le Heuzey JY, De Ferrari GM, Radzik D, Santini M, Zhu J, Davy JM (2010): A short-term, randomized, double-blind, parallel-group study to evaluate the efficacy and safety of dronedarone versus amiodarone in patients with persistent atrial fibrillation: The DIONYSOS Study. J Cardiovasc Electrophysiol 21: 597–605.
Maresta A, Balducelli M, Latini R, Bernardi G, Moccetti T, Sosa C, Barlera S, Varani E, Ribeiro da Silva EE, Monici Preti A, Maggioni AP; STARC II Investigators (2005): Starc II, a multicenter randomized placebo-controlled double-blind clinical trial of trapidil for 1-year clinical events and angiographic restenosis reduction after coronary angioplasty and stenting. Catheter Cardiovasc Interv. 64: 375–382.
McMurray JJ, Adamopoulos S, Anker SD, Auricchio A, Böhm M et al. ESC Committee for Practice Guidelines (2012): ESC Guidelines for the diagnosis and treatment of acute and chronic heart failure 2012: The Task Force for the Diagnosis and Treatment of Acute and Chronic Heart Failure 2012 of the European Society of Cardiology. Developed in collaboration with the Heart Failure Association (HFA) of the ESC. Eur Heart J. 33: 1787–1847.
Meinertz T, Lehmacher W for the Trapidil/ISDN Study Group (2006): Trapidil is as effective as isosorbidedinitrate for treating stable angina pectoris – a multinational, multicenter, double-blind, randomized study. Clin Res Cardiol. 95: 217–223.
Mest HJ (1990): Trapidil: a potent inhibitor of platelet aggregation. J Drug Dev 3: 143–149.
Morrow DA, Scirica BM, Sabatine MS, de Lemos JA, Murphy SA, Jarolim P, Theroux P, Bode C, Braunwald E (2010) B-type natriuretic peptide and the effect of ranolazine in patients with non-ST-segment elevation acute coronary syndromes: observations from the MERLIN-TIMI 36 (Metabolic Efficiency With Ranolazine for Less Ischemia in Non-ST-Elevation Acute Coronary-Thrombolysis In Myocardial Infarction 36) trial. J Am Coll Cardiol 55: 1189–1196.
Moss AJ, Zareba W, Hall WJ, Klein H, Wilber DJ, Cannom DS, Daubert JP, Higgins SL, Brown MW, Andrews ML for the Multicenter Automatic Defibrillator Implantation Trial II Investigators (2002): Prophylactic implantation of a defibrillator in patients with myocardial infarction and reduced ejection fraction. N Engl J Med. 346: 877–883.
Nationale Versorgungsleitlinie Chronische Herzinsuffizienz. März 2012. www.versorgungsleitlinien.de/themen/herzinsuffizienz/pdf/nvl_hi_lang.pdf
Patten M, Maas R, Bauer P, Luderitz B, Sonntag F, Dluzniewski M, Hatala R, Opolski G, Muller HW, Meinertz T; SOPAT Investigators (2004) Suppression of paroxysmal atrial tachyarrhythmias--results of the SOPAT trial. Eur Heart J 25: 1395–404.
Rathore SS, Curtis JP, Wang Y, Bristow MR, Krumholz HM (2003): Association of serum digoxin concentration and outcomes in patients with heart failure. JAMA 289: 871–878.
Roy D, Talajic M, Nattel S, Wyse DG, Dorian P, Lee KL et al. (2008) Rhythm control versus rat control for atrial fibrillation and heart failure. N Engl J Med 358: 2667–2677.
Sanders GD, Hlatky MA, Owens DK (2005): Cost-effectiveness of implantable cardioverter- defibrillators. N Engl J Med 353: 1471–80.
Schmiedl S, Szymanski J, Rottenkolber M, Hasford J, Thurmann PA (2007) Re: Ageand gender-specific incidence of hospitalisation for digoxin intoxication. Drug Saf 30:1171–1173; author reply 1173–1174.
Swedberg K, Komajda M, Böhm M, Borer JS, Ford I, Dubost-Brama A, Lerebours G, Tavazzi L; SHIFT Investigators (2010): Ivabradine and outcomes in chronic heart failure (SHIFT): a randomised placebo-controlled study. Lancet. 376: 875–885.
The Digitalis Investigation Group (1997): The effect of digoxin on mortality and morbidity in patients with heart failure. N Engl J Med 336: 525–533.
Tardif JC (2007): Clinical results of I(f) current inhibition by ivabradine. Drugs 67 Suppl 2: 35–41.
Tardif JC, Ford I, Tendera M, Bourassa MG, Fox K (2005): Efficacy of ivabradine, a new selective I(f) inhibitor, compared with atenolol in patients with chronic stable angina. Eur Heart J 26: 2529–2536.
Vaughan Williams EM (1975): Classification of antidysrhythmic drugs. Pharmac Ther B 1: 115–138.
Wagner F, Gohlke-Barwolf C, Trenk D, Jähnchen E, Roskamm H (1991): Differences in the antiischaemic effects of molsidomine and isosorbide dinitrate (ISDN) during acute and short-term administration in stable angina pectoris. Eur Heart J 12: 994–999.
Wenzel P, Hink U, Oelze M, Seeling A, Isse T, Bruns K, Steinhoff L, Brandt M, Kleschyov AL, Schulz E, Lange K, Weiner H, Lehmann J, Lackner KJ, Kawamoto T, Munzel T, Daiber A (2007): Number of nitrate groups determines reactivity and potency of organic nitrates: a proof of concept study in ALDH-2-/- mice. Br J Pharmacol 150: 526–33.
Wyse DG, Waldo AL, DiMarco JP, Domanski MJ, Rosenberg Y, Schron EB, Kellen JC, Greene HL, Mickel MC, Dalquist JE, Corley SD; Atrial Fibrillation Follow-up Investigation of Rhythm Management (AFFIRM) Investigators (2002): A comparison of rate control and rhythm control in patients with atrial fibrillation. N Engl J Med 347: 1825–1833.
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Eschenhagen, T. (2013). Herztherapeutika. In: Schwabe, U., Paffrath, D. (eds) Arzneiverordnungs-Report 2013. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-642-37124-0_27
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