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Leytus, S.P.; Loeb, K.R.; Hagen, F.S.; Kurachi, K.; Davie, E.W.: A novel trypsin-like serine protease (hepsin) with a putative transmembrane domain expressed by human liver and hepatoma cells. Biochemistry, 27, 1067–1074 (1988)
Zhukov, A.; Hellman, U.; Ingelman-Sundberg, M.: Purification and characterization of hepsin from rat liver microsomes. Biochim. Biophys. Acta, 1337, 85–95 (1997)
Tsuji, A.; Torres-Rosado, A.; Arai, T.; Chou, S.H.; Kurachi, K.: Characterization of hepsin, a membrane bound protease. Biomed. Biochim. Acta, 50, 791–793 (1991)
Srikantan, V.; Valladares, M.; Rhim, J.S.; Moul, J.W.; Srivastava, S.: Hepsin inhibits cell growth/invasion in prostate cancer cells. Cancer Res., 62, 6812–6816 (2002)
Tsuji, A.; Torres-Rosado, A.; Arai, T.; Le Beau, M.M.; Lemons, R.S.; Chou, S.H.; Kurachi, K.: Hepsin, a cell membrane-associated protease. Characterization, tissue distribution, and gene localization. J. Biol. Chem., 266, 16948–16953 (1991)
Kazama, Y.; Hamamoto, T.; Foster, D.C.; Kisiel, W.: Hepsin, a putative membrane-associated serine protease, activates human factor VII and initiates a pathway of blood coagulation on the cell surface leading to thrombin formation. J. Biol. Chem., 270, 66–72 (1995)
Kurachi, K.; Torres-Rosado, A.; Tsuji, A.: Hepsin. Methods Enzymol., 244, 100–114 (1994)
Torres-Rosado, A.; O’Shea, K.S.; Tsuji, A.; Chou, S.H.; Kurachi, K.: Hepsin, a putative cell-surface serine protease, is required for mammalian cell growth. Proc. Natl. Acad. Sci. USA, 90, 7181–7185 (1993)
Somoza, J.R.; Ho, J.D.; Luong, C.; Ghate, M.; Sprengeler, P.A.; Mortara, K.; Shrader, W.D.; Sperandio, D.; Chan, H.; McGrath, M.E.; Katz, B.A.: The structure of the extracellular region of human hepsin reveals a serine protease domain and a novel scavenger receptor cysteine-rich (SRCR) domain. Structure, 11, 1123–1131 (2003)
Zhang, J.L.; Zhao, W.G.; Wu, K.L.; Wang, K.; Zhang, X.; Gu, C.F.; Li, Y.; Zhu, Y.; Wu, J.G.: Human hepatitis B virus X protein promotes cell proliferation and inhibits cell apoptosis through interacting with a serine protease hepsin. Arch. Virol., 150, 721–741 (2005)
Herter, S.; Piper, D.E.; Aaron, W.; Gabriele, T.; Cutler, G.; Cao, P.; Bhatt, A.S.; Choe, Y.; Craik, C.S.; Walker, N.; Meininger, D.; Hoey, T.; Austin, R.J.: Hepatocyte growth factor is a preferred in vitro substrate for human hepsin, a membrane-anchored serine protease implicated in prostate and ovarian cancers. Biochem. J., 390, 125–136 (2005)
Li, Y.; Yu, Z.; Zhao, X.; Shen, S.: Identification and characterization of hepsin/-TM, a non-transmembrane hepsin isoform. Biochim. Biophys. Acta, 1681, 157–165 (2005)
Klezovitch, O.; Chevillet, J.; Mirosevich, J.; Roberts, R.L.; Matusik, R.J.; Vasioukhin, V.: Hepsin promotes prostate cancer progression and metastasis. Cancer Cell, 6, 185–195 (2004)
Kirchhofer, D.; Peek, M.; Lipari, M.T.; Billeci, K.; Fan, B.; Moran, P.: Hepsin activates pro-hepatocyte growth factor and is inhibited by hepatocyte growth factor activator inhibitor-1B (HAI−1B) and HAI−2. FEBS Lett., 579, 1945–1950 (2005)
Nakamura, K.; Nasu, Y.; Hongo, A.; Matsuo, T.; Kodama, J.; Ebara, S.; Nagai, A.; Abrzua, F.; Kumon, H.; Hiramatsu, Y.: Hepsin shows inhibitory effects through apoptotic pathway on ovarian cancer cell lines. Int. J. Oncol., 28, 393–398 (2006)
Roemer, A.; Schwettmann, L.; Jung, M.; Stephan, C.; Roigas, J.; Kristiansen, G.; Loening, S.A.; Lichtinghagen, R.; Jung, K.: The membrane proteases adams and hepsin are differentially expressed in renal cell carcinoma. Are they potential tumor markers?. J. Urol., 172, 2162–2166 (2004)
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(2009). Hepsin. In: Chang, A. (eds) Class 3 Hydrolases. Springer Handbook of Enzymes, vol S5. Springer, Berlin, Heidelberg. https://doi.org/10.1007/978-3-540-85703-7_46
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DOI: https://doi.org/10.1007/978-3-540-85703-7_46
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